DPTN dihydrochloride
Based on 1 Customer Validation
DPTN is a potent and selective human, mouse, and rat A3AR antagonist with Ki values of 1.65, 9.61, and 8.53 nM, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 98.47%
- No. CAS: 325767-87-1
- Fòrmula: C22H20Cl2N4OS
- Peso molecular:459.39
-
Almacenamiento:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
Ver todos los productos específicos de isoformas Adenosine Receptor
More
Actividad biológica
|
hA3 1.65 nM (Ki) |
DPTN is indeed a potent antagonist for human, mouse, and rat A3ARs . DPTN is weaker at mouse and rat compared with human A3AR and has reduced selectivity (about 20-fold vs A2BAR).[1]. The Binding affinity of BNPT (10 μM) is tested in membranes of transfected HEK293 cells, the Ki values are 162 ± 49, 121 ± 42, 230 ± 40, and 1.65 ± 0.57 nM for hA1, hA2A, hA2B, and hA3, respectively[1]. DPTN’s Ki values at respective A1, A2A, A2B, and A3 receptors are 411, 830, 189, and 9.61 nM (mouse); and 333, 1147, 163, and 8.53 nM (rat) [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 325767-87-1
-
Appearance Solid
-
Peso molecular 459.39
-
Fòrmula C22H20Cl2N4OS
-
Color Light yellow to yellow
-
SMILES
O=C(C1=CC=CN=C1)NC2=NC(C3=CC(C)=CC(C)=C3)=C(C4=CC=NC=C4)S2.Cl.Cl
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvente y solubilidad
DMSO : 5 mg/mL (10.88 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1768 mL | 10.8840 mL | 21.7680 mL | 54.4200 mL |
| 5 mM | 0.4354 mL | 2.1768 mL | 4.3536 mL | 10.8840 mL | |
| 10 mM | 0.2177 mL | 1.0884 mL | 2.1768 mL | 5.4420 mL |
DPTN dihydrochloride Related Classifications
HY-153152 Related Classifications
Powered by Bioz