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Cat. No.: HY-N10286

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Chetoseminudin B

Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM.

For research use only. We do not sell to patients.

CAS No.: 658711-87-6
Formula: C₁₇H₂₁N₃O₃S₂
Molecular Weight:379.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Chetoseminudin B Chemical Structure

CAS No.: 658711-87-6

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM^[1].

IC₅₀ & Target

IC₅₀: 31.7 μM (mushroom tyrosinase)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human HepG2 cells by SRB method Cytotoxicity against human HepG2 cells by SRB method	[PMID: 23079524]
Jurkat	IC₅₀	94.9 μM Compound: 8	Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay Cytotoxicity against human Jurkat cells after 40 hrs bioluminescence assay	[PMID: 20303767]
Lymphocyte	IC₅₀	24 μM Compound: 8	Immunosuppression of mouse spleen lymphocytes Immunosuppression of mouse spleen lymphocytes	[PMID: 20303767]
MCF7	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human MCF7 cells by SRB method Cytotoxicity against human MCF7 cells by SRB method	[PMID: 23079524]
NCI-H460	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human NCI-H460 cells by SRB method Cytotoxicity against human NCI-H460 cells by SRB method	[PMID: 23079524]
SF-268	IC₅₀	>100 μM Compound: 6	Cytotoxicity against human SF268 cells by SRB method Cytotoxicity against human SF268 cells by SRB method	[PMID: 23079524]
T-cell	IC₅₀	24 μg/mL Compound: 3, CS-C	Immunosuppressive activity in BALB/c mouse splenic T lymphocytes assessed as inhibition of Con A-induced cell proliferation after 72 hrs by MTT assay Immunosuppressive activity in BALB/c mouse splenic T lymphocytes assessed as inhibition of Con A-induced cell proliferation after 72 hrs by MTT assay	[PMID: 14738397]

Chemical Information

CAS No. 658711-87-6
Molecular Weight 379.50
Formula C₁₇H₂₁N₃O₃S₂
SMILES

CS[C@]1(C(N([C@@](SC)(C(N1)=O)CO)C)=O)CC2=CNC3=CC=CC=C23
Structure Classification
- Alkaloids
- Indole Alkaloids
Initial Source
- Microorganisms
Phaeosphaeria fuckelii
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhai YJ, et al. Phaeosphaones: Tyrosinase Inhibitory Thiodiketopiperazines from an Endophytic Phaeosphaeria fuckelii. J Nat Prod. 2020;83(5):1592-1597. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References