Immunomodulatory constituents from an Ascomycete, Chaetomium seminudum

  • J Nat Prod. 2004 Jan;67(1):98-102. doi: 10.1021/np0302201.
Haruhiro Fujimoto  1 ,  Megumi Sumino ,  Emi Okuyama ,  Masami Ishibashi
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan. [email protected]
PMID: 14738397 DOI: 10.1021/np0302201
Abstract

A screening study focusing on immunomodulatory activity of the EtOAc extract of an Ascomycete, Chaetomium seminudum, has afforded a known epipolythiodioxopiperazine, chetomin (1), together with three new chetomin-related metabolites named chetoseminudins A (2), B (3), and C (4). Among these four metabolites, 1 and 2 have been deduced as the immunosuppressive features of this fungus.