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Results for "

Aspergillus fumigatus

" in MedChemExpress (MCE) Product Catalog:

68

Inhibitors & Agonists

1

Biochemical Assay Reagents

5

Peptides

40

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-104029
    Olorofim

    F901318

    		 Fungal Dihydroorotate Dehydrogenase Infection
    Olorofim (F901318) selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in the pyrimidine biosynthesis pathway. Olorofim (F901318). Olorofim exhibits excellent activity against A. fumigatus and other Aspergillus spp. .
    Olorofim
  • HY-N1063
    Xanthoxylin

    Xanthoxyline

    		 Fungal Infection Metabolic Disease
    Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .
    Xanthoxylin
  • HY-B0751
    Fumagillin
    1 Publications Verification

    Amebacilin; NSC9168

    		 Parasite HIV Antibiotic Infection
    Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.
    Fumagillin
  • HY-117766
    Opelconazole

    PC945

    		 Fungal Cytochrome P450 Infection
    Opelconazole (PC945), a potent, long-acting antifungal triazole, possesses activity against a broad range of both azole-susceptible and azole-resistant strains of Aspergillus fumigatus. Opelconazole is also a potent, tightly binding inhibitor of A. fumigatus sterol 14α-demethylase activity, CYP51A and CYP51B, with IC50s of 0.23 μM and 0.22 μM, respectively .
    Opelconazole
  • HY-W007626
    3,5-Dimethoxybenzaldehyde

    		Fungal Infection
    3,5-Dimethoxybenzaldehyde is an antifungal agent. 3,5-Dimethoxybenzaldehyde exhibits antifungal activity against Saccharomyces cerevisiae cell wall integrity mutants (slt2Δ and bck1Δ) and Aspergillus fumigatus MAPK mutants (sakAΔ and mpkCΔ) .
    3,5-Dimethoxybenzaldehyde
  • HY-P2543
    Neuropeptide Y (3-36) (human, rat)
    1 Publications Verification

    		 Neuropeptide Y Receptor Cardiovascular Disease Neurological Disease
    Neuropeptide Y (3-36) (human, rat) is a neuropeptide Y fragment derived from humans or rats. Neuropeptide Y is an extremely abundant neurotransmitter in central and peripheral neurons, and it participates in the regulation of psychomotor activity, circadian rhythm, feeding behavior and cardiovascular function. Neuropeptide Y (3-36) (human, rat) can serve as a substrate to be sequentially degraded from its N-terminus by AfuS28, and it requires binding to AfuS28 and SedB to be decomposed into amino acids, dipeptides and tripeptides [1] [2].
    Neuropeptide Y (3-36) (human, rat)
  • HY-147110
    APX2039

    		Fungal Infection Inflammation/Immunology
    APX2039 is a brain-penetrant and orally active Gwt1 protein inhibitor. APX2039 inhibits an early step in fungal glycosylphosphatidylinositol anchor biosynthesis. APX2039 can be used for the research of cryptococcal meningitis and invasive mycosis caused by Talaromyces marneffei .
    APX2039
  • HY-N2198
    Podocarpusflavone A

    		Fungal Bacterial Topoisomerase Apoptosis Infection Inflammation/Immunology Cancer
    Podocarpusflavone A is a biflavonoid present in the leaves of Podocarpus henkelii, with anti-tumor, topoisomerase I inhibitory, antibacterial and antifungal activities. Podocarpusflavone A exhibits antibacterial activity against Enterococcus faecalis and Pseudomonas aeruginosa. Podocarpusflavone A shows weak activity against fungal pathogens. Podocarpusflavone A targets topoisomerase I and induces cell cycle arrest and apoptosis in MCF-7 cells. Podocarpusflavone A can be used for studies on cancer, bacterial and fungal infections .
    Podocarpusflavone A
  • HY-W068682
    1-Hydroxyphenazine

    Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin

    		 Amylases Bacterial Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL . 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris .
    1-Hydroxyphenazine
  • HY-121254
    GERI-BP002-A

    		Environmental Pollutants Acyltransferase Cancer
    GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .
    GERI-BP002-A
  • HY-P2274
    Argifin

    		Parasite Infection
    Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms, with IC50s of 0.025 μM, 6.4 μM , 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase, respectively .
    Argifin
  • HY-136153
    Amphotericin X1

    		Fungal Infection
    Amphotericin X1 is an 13-O-methyl derivative of Amphotericin B with good antifungal activity. Amphotericin X1 inhibits Candida albicans 33/079, C.parapsilosis 937A, Cryptococcus neoformans 451, Aspergillus niger 57A and A.fumigatus with MIC values of 1 μg/mL, 8 μg/mL, 1 μg/mL, 2 μg/mL and 2 μg/mL, respectively .
    Amphotericin X1
  • HY-126657
    Fumigaclavine A

    		Fungal Infection
    Fumigaclavine A, a clavine alkaloid, is a Mycotoxin produced by Aspergillus fumigatus. A. fumigatus can be isolated from contaminating moldy silage .
    Fumigaclavine A
  • HY-133101
    14-Norpseurotin

    		Endogenous Metabolite Cancer
    14-Norpseurotin is a compound isolated from the culture of Aspergillus fumigatus. 14-Norpseurotin significantly induces neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration .
    14-Norpseurotin
  • HY-170616
    JH-FK-08

    		Fungal Interleukin Related Infection Inflammation/Immunology
    JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models .
    JH-FK-08
  • HY-W782599
    Senkyunolide B

    		Fungal PKC Calcineurin Infection
    Senkyunolide B is a phthalide found in Angelica sinensis. Senkyunolide B has broad antifungal activities. Senkyunolide B affects the spore germination and hyphae growth of Aspergillus fumigatus via down-regulating phosphatidylinositol-PKC-calcineurin axis and the expression of ENG genes .
    Senkyunolide B
  • HY-N1063R
    Xanthoxylin (Standard)

    Xanthoxyline (Standard)

    		 Reference Standards Fungal Infection Metabolic Disease
    Xanthoxylin (Xanthoxyline) can be isolated from Zanthoxylum simulans. Xanthoxylin has antifungal and antioxidant effects. The MIC of Xanthoxylin against Toxoplasma neonatorum and Aspergillus fumigatus were 50 µg/mL and 75 µg/mL, respectively. Xanthoxylin can be used in the study of anti-epileptic diseases .
    Xanthoxylin (Standard)
  • HY-B0751R
    Fumagillin (Standard)

    Amebacilin (Standard); NSC9168 (Standard)

    		 Reference Standards Parasite HIV Antibiotic Infection
    Fumagillin (Standard) is the analytical standard of Fumagillin. This product is intended for research and analytical applications. Fumagillin(NSC9168) is an antimicrobial compound first isolated in 1949 from the fungus Aspergillus fumigatu. Fumagillin can inhibits HIV‐1 infection through the inhibition of HIV-1 viral protein R (Vpr) activity.
    Fumagillin (Standard)
  • HY-W077257
    5-Bromo-DL-tryptophan

    		Endogenous Metabolite Others
    5-Bromo-DL-tryptophan is a natural product which can be obtained from Aspergillus fumigatus .
    5-Bromo-DL-tryptophan
  • HY-N7569
    Demethoxyfumitremorgin C

    		Apoptosis Caspase PPAR Cancer
    Demethoxyfumitremorgin C is a secondary metabolite of the marine fungus, Aspergillus fumigatus. Demethoxyfumitremorgin C induces prostate cancer cell apoptosis. Demethoxyfumitremorgin C activates caspase-3, -8, and -9, leading to PARP/ cleavage .
    Demethoxyfumitremorgin C
  • HY-N8406
    Monomethylsulochrin

    		Bacterial Antibiotic Infection
    Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .
    Monomethylsulochrin
  • HY-164620
    Antifungal agent 112

    		Fungal Infection
    Antifungal agent 112 (Compound 1e) exhibits antifungal activity against Candida albicans, Aspergillus niger and Aspergillus fumigatus with MIC of 0.0024, 0.0022 and 0.0028 M, respectively .
    Antifungal agent 112
  • HY-108079
    KOS-2079

    		Fungal Infection
    KOS-2079 is an antifungal agent. KOS-2079 has strong inhibitory activity against Aspergillus flavus 204303 (MIC = 1.10 μg/mL) and Aspergillus fumigatus 204305 (MIC = 1.32 μg/mL). KOS-2079 is commonly used in the study of fungal infection .
    KOS-2079
  • HY-106923
    BMS-181184

    		Fungal Drug Derivative Infection
    BMS-181184 is a new Pradimicin derivative and fungicide. BMS-181184 exhibits fungicidal activity against yeasts, dermatophytes, and most Aspergillus fumigatus strains. BMS-181184 is active against Sporothrix schenckii, dematiaceous fungi, and some members of the non-Aspergillus hyaline hyphomycetes .
    BMS-181184
  • HY-138050
    Nyasol

    (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol

    		 NO Synthase Bacterial Fungal Parasite Leukotriene Receptor Infection Inflammation/Immunology
    Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .
    Nyasol
  • HY-19404
    Embeconazole

    CS-758; R-120758

    		 Fungal Infection
    Embeconazole (CS-758; R-120758) is an antifungal agent against Candida albicans, Cryptococcus neoformans, Aspergillus fumigatus and Aspergillus flavus, with MICs of 8, 16, 63 and 250 μM, respectively .
    Embeconazole
  • HY-W104752
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol

    		Bacterial Fungal Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol (Compound 3n) is an antimicrobial and antioxidant agent, that inhibits Escherichia coli and Staphylococcus epidermidis, with MIC of 8 and 4 μg/mL. 5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol exhibits antioxidant activity with IC50 of 17.47 μM using DPPH free radical-scavenging method .
    5-(Pyridin-4-yl)-1,3,4-oxadiazole-2-thiol
  • HY-146464
    Antifungal agent 30

    		Fungal Infection
    Antifungal agent 30 (compound A18) is a potent antifungal agent. Antifungal agent 30 shows excellent antifungal activity against Candida albicans (CPCC400616) and Aspergillus fumigatus, with MIC of 0.03 and 0.5 μg/mL, respectively. Antifungal agent 30 also shows excellent antifungal activity against fluconazole-resistant strains. The potent antifungal activity of Antifungal agent 30 mainly causes by hydrogen and coordination bond interaction with the CYP51 .
    Antifungal agent 30
  • HY-N14960
    Clavariopsin A

    		Antibiotic
    Clavariopsin A is a cyclic depsipeptide antibiotic. Clavariopsin A shows antifungal activity for Candida albicans IFO 0583, Candida albicans ATCC 10231, Aspergillus niger AJ117374, Aspergillus fumigatus AJ117190, Aspergillus fumigatus JCM1739 with MIC values of 8, 8, 16, 2, 4 μg/mL, respectively .
    Clavariopsin A
  • HY-N14961
    Clavariopsin B

    		Antibiotic Infection
    Clavariopsin B is a cyclic depsipeptide antibiotic. Clavariopsin B shows antifungal activity for Candida albicans IFO 0583, Candida albicans ATCC 10231, Aspergillus niger AJ117374, Aspergillus fumigatus AJ117190, Aspergillus fumigatus JCM1739 with MIC values of 8, 8, 16, 4, 4 μg/mL, respectively .
    Clavariopsin B
  • HY-N14509
    Queenslandon

    		Fungal Infection
    Queenslandon has moderate anti-streptomyces, penicillium, Penicillium, Aspergillus fumigatus, aspergillus flavus and other fungal activities. And it has no effect on bacteria .
    Queenslandon
  • HY-N14102
    Chlorflavonin

    		Fungal Infection
    Chlorflavonin has the activities of anti-aspergillus, yeast, botrytis, and other fungal. Among these fungi, anti-Aspergillus fumigatus activity is particularly strong, the minimum inhibitory concentration up to 0.08 μg/mL .
    Chlorflavonin
  • HY-N14011
    Cedarmycin A

    		Antibiotic Bacterial Infection
    Cedarmycin A has activities against Candida, Cryptococcus neoforme and Aspergillus fumigatus, with the MIC values of 12.5-50 μg/mL .
    Cedarmycin A
  • HY-N14122
    Cladosporide B

    		Fungal Infection
    Cladosporide B is found in the strain of Cladosporium sp. IFM 49189. Cladosporide B has slightly stronger anti-Aspergillus fumigatus activity than Cladosporide A .
    Cladosporide B
  • HY-P5569
    SP-B peptide

    		Fungal Infection
    SP-B peptide is an antimicrobial peptide. SP-B peptide has antifungal activity against strains of Cryptococcus neoformans, Candida albicans and Aspergillus fumigatus
    SP-B peptide
  • HY-N14018
    Glidobactin A

    		Antibiotic Fungal Infection
    Glidobactin A is an acyl peptide antibiotic. Glidobactin A has activity against Candida, Aspergillus fumigatus and Trichophyton, but it is not effective against Candida albicans M-9 infection in mice .
    Glidobactin A
  • HY-N14121
    Cladosporide A

    		Fungal Infection
    Cladosporide A is found in the strain of Cladosporium sp. IFM 49189. Cladosporide A inhibits Aspergillus fumigatus with IC50 of 0.5-4.0 μg/mL, but it has no effect on other filamentous fungi .
    Cladosporide A
  • HY-N14614
    Pyripyropene B

    		Acyltransferase Metabolic Disease
    Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC50 of 117 nM .
    Pyripyropene B
  • HY-N16051
    Bromoflavone

    CJ-19784

    		 Bacterial Fungal Infection
    Bromoflavone (CJ-19784) is a flavone that can be isolated from Aspergillus candidus. Bromoflavone shows anti-Mtb activity with an MIC90 value of 1.2 μM. Bromoflavone is also an antifungal agent. Bromoflavone inhibits the growth of pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with IC50 values of 0.11, 20 and 0.54 μg/mL, respectively. .
    Bromoflavone
  • HY-N8336
    IT-143A

    		Antibiotic Bacterial Fungal Infection Cancer
    IT-143A is an antibiotic, that exhibits antibacterial and antifungal activity against Micrococcus luteus and Aspergillus fumigatus with MIC of 6.25-25 μg/mL. IT-143A inhibits growth of cancer cell KB with an IC50 of 0.36 ng/mL .
    IT-143A
  • HY-P0068
    Aminocandin

    HMR 3270; IP960; NXL201

    		 Fungal Infection
    Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp. .
    Aminocandin
  • HY-N15048
    Phellinsin

    		Fungal Infection
    Phellinsin selectively inhibits the activity of the chitin synthase I and II with IC50s (μg/mL) of 76 and 28, respectively. Phellinsin has the antifungal activity on Colletotrichum lagenarium, Pyricularia oryzae, Aspergillus fumigatus and Trichophyton mentagrophytes and so on (MIC is 12.5-50 μg/mL) .
    Phellinsin
  • HY-N5160
    Arborcandin A

    		Antibiotic Fungal Infection
    Arborcandin A is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin A exhibits IC50 values of 0.25 μg/mL and 0.05 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin A has an MIC of 4-8 μg/mL against the genus Candida .
    Arborcandin A
  • HY-N5165
    Arborcandin F

    		Antibiotic Fungal Infection
    Arborcandin F is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin F exhibits IC50 values of 0.012 μg/mL against both Candida albicans and Aspergillus fumigatus. Additionally, Arborcandin F has an MIC of 2-4 μg/mL against the genus Candida .
    Arborcandin F
  • HY-N5163
    Arborcandin D

    		Antibiotic Fungal Infection
    Arborcandin D is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin D exhibits IC50 values of 3 μg/mL and 0.35 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin D has an MIC of 4 μg/mL against the genus Candida .
    Arborcandin D
  • HY-N14020
    Glidobactin C

    GlbC

    		 Antibiotic Fungal Infection Cancer
    Glidobactin C (GlbC) is an anti-tumor antibiotic. Glidobactin C (GlbC) has the activity against pathogenic fungi and yeast. Glidobactin C has anti-Candida albicans and Aspergillus fumigatus activity with a MIC of 0.8 μg/mL. Glidobactin C also extends the survival of mice inoculated with leukemia P388 cells .
    Glidobactin C
  • HY-N5162
    Arborcandin C

    		Antibiotic Fungal Infection
    Arborcandin C is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin C exhibits IC50 values of 0.15 μg/mL and 0.015 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin C has an MIC of 1-2 μg/mL against the genus Candida .
    Arborcandin C
  • HY-N5161
    Arborcandin B

    		Antibiotic Fungal Infection
    Arborcandin B is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin B exhibits IC50 values of 0.30 μg/mL and 0.025 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin B has an MIC of 2-4 μg/mL against the genus Candida .
    Arborcandin B
  • HY-N5164
    Arborcandin E

    		Antibiotic Fungal Infection
    Arborcandin E is a 1,3-β-glucan synthase inhibitor that serves as an antifungal antibiotic. Arborcandin E exhibits IC50 values of 0.1 μg/mL and 0.012 μg/mL against Candida albicans and Aspergillus fumigatus, respectively. Additionally, Arborcandin E has an MIC of 0.5-2 μg/mL against the genus Candida .
    Arborcandin E
  • HY-N12106
    Neosartoricin

    Fumicycline

    		 Endogenous Metabolite Fungal Infection
    Neosartoricin (Fumicycline) (Compound 3), a prenylated anthracenone, is a microbial secondary metabolite. Neosartoricin can be isolated from Aspergillus fumigatus and Neosartorya fischeri. Neosartoricin has immunosuppressive activity, and significantly inhibits T-cell proliferative activity with an IC50 of 3 μM. Neosartoricin may be beneficial to fungal defense, facilitating infection through suppressing the host adaptive immunity without involvement of primary virulence .
    Neosartoricin

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