GERI-BP002-A
Based on 1 Customer Validation
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research.
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- Purity : 99.77%
- CAS No.: 119-47-1
- 화학식: C23H32O2
- 분자량:340.50
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보관:
RT, stored under nitrogen.
In solvent -80°C, 1 year , -20°C, 6 months
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
In Vitro
GERI-BP002-A exhibits cytotoxicity against A549, SKOV-3, HCT-15, XF-498, and SKMEL-2 cells, with ED50 values of 5.45 μg/mL, 8.83 μg/mL, 5.79 μg/mL, 7.30 μg/mL, and 5.39 μg/mL, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 119-47-1
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Appearance Solid
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분자량 340.50
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화학식 C23H32O2
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Color White to off-white
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SMILES
OC1=C(C(C)(C)C)C=C(C)C=C1CC2=CC(C)=CC(C(C)(C)C)=C2O
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Structure Classification
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Initial Source
spergillus fumigatus
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선적
Room temperature in continental US; may vary elsewhere.
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보관
RT, stored under nitrogen
In solvent -80°C 1 year -20°C 6 months
용액&용해도
In Vitro:
DMSO : 100 mg/mL (293.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo:
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (14.68 mM); Clear solution
This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (271 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9369 mL | 14.6843 mL | 29.3686 mL | 73.4214 mL |
| 5 mM | 0.5874 mL | 2.9369 mL | 5.8737 mL | 14.6843 mL | |
| 10 mM | 0.2937 mL | 1.4684 mL | 2.9369 mL | 7.3421 mL | |
| 15 mM | 0.1958 mL | 0.9790 mL | 1.9579 mL | 4.8948 mL | |
| 20 mM | 0.1468 mL | 0.7342 mL | 1.4684 mL | 3.6711 mL | |
| 25 mM | 0.1175 mL | 0.5874 mL | 1.1747 mL | 2.9369 mL | |
| 30 mM | 0.0979 mL | 0.4895 mL | 0.9790 mL | 2.4474 mL | |
| 40 mM | 0.0734 mL | 0.3671 mL | 0.7342 mL | 1.8355 mL | |
| 50 mM | 0.0587 mL | 0.2937 mL | 0.5874 mL | 1.4684 mL | |
| 60 mM | 0.0489 mL | 0.2447 mL | 0.4895 mL | 1.2237 mL | |
| 80 mM | 0.0367 mL | 0.1836 mL | 0.3671 mL | 0.9178 mL | |
| 100 mM | 0.0294 mL | 0.1468 mL | 0.2937 mL | 0.7342 mL |
GERI-BP002-A Related Classifications
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