2. Anti-infection
  3. Fungal
  4. APX2039

APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research.

For research use only. We do not sell to patients.

APX2039 Chemical Structure

APX2039 Chemical Structure

CAS No. : 2342606-49-7

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 558 In-stock
Solution
10 mM * 1 mL in DMSO USD 558 In-stock
Solid
1 mg USD 240 In-stock
5 mg USD 700 In-stock
10 mg USD 1120 In-stock
25 mg USD 2250 In-stock
50 mg USD 3600 In-stock
100 mg USD 5800 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

APX2039 Related Antibodies

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Description

APX2039 is an orally active and potent inhibitor of the fungal Gwt1 enzyme. APX2039 has extremely potent anticryptococcal activity against C. neoformans and C. gattii. APX2039 blocks the localization of GPI (glycosylphosphatidyl inositol)-anchored cell wall mannoproteins. APX2039 can be used for Cryptococcal meningitis (CM) research[1][2].

Molecular Weight

362.36

Formula

C20H15FN4O2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

NC1=NC=CC=C1C2=CC(CC3=CC=C(C=C3)OC4=NC(F)=CC=C4)=NO2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (275.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7597 mL 13.7984 mL 27.5969 mL
5 mM 0.5519 mL 2.7597 mL 5.5194 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7597 mL 13.7984 mL 27.5969 mL 68.9922 mL
5 mM 0.5519 mL 2.7597 mL 5.5194 mL 13.7984 mL
10 mM 0.2760 mL 1.3798 mL 2.7597 mL 6.8992 mL
15 mM 0.1840 mL 0.9199 mL 1.8398 mL 4.5995 mL
20 mM 0.1380 mL 0.6899 mL 1.3798 mL 3.4496 mL
25 mM 0.1104 mL 0.5519 mL 1.1039 mL 2.7597 mL
30 mM 0.0920 mL 0.4599 mL 0.9199 mL 2.2997 mL
40 mM 0.0690 mL 0.3450 mL 0.6899 mL 1.7248 mL
50 mM 0.0552 mL 0.2760 mL 0.5519 mL 1.3798 mL
60 mM 0.0460 mL 0.2300 mL 0.4599 mL 1.1499 mL
80 mM 0.0345 mL 0.1725 mL 0.3450 mL 0.8624 mL
100 mM 0.0276 mL 0.1380 mL 0.2760 mL 0.6899 mL
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APX2039 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APX20392342606-49-7APX 2039APX-2039FungalCryptococcal meningitisCMCryptococcus neoformansorally activefungalanticryptococcalInhibitorinhibitorinhibit

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