2342606-49-7
2342606-49-7
Chemical Structure
APX2039
- CAS No.: 2342606-49-7
- Formula:C20H15FN4O2
- Molecular Weight:362.36
IUPAC Name: (7-chloroquinolin-8-yl)methanol
InChIKey: HSPXTNVHQPVEGF-UHFFFAOYSA-N
SMILES: NC1=NC=CC=C1C2=CC(CC3=CC=C(C=C3)OC4=NC(F)=CC=C4)=NO2
Biological Activity: APX2039 is a brain-penetrant and orally active Gwt1 protein inhibitor. APX2039 inhibits an early step in fungal glycosylphosphatidylinositol anchor biosynthesis. APX2039 can be used for the research of cryptococcal meningitis and invasive mycosis caused by Talaromyces marneffei[1][2][3].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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APX2039 | 98.44% | APX2039 is a brain-penetrant and orally active Gwt1 protein inhibitor. APX2039 inhibits an early step in fungal glycosylphosphatidylinositol anchor biosynthesis. APX2039 can be used for the research of cryptococcal meningitis and invasive mycosis caused by Talaromyces marneffei. | ||||||||||||||||||||
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References
- [1]. Giamberardino CD, et al. Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis. mBio. 2022;13(6):e0234722. [Content Brief]
- [2]. Barwatt J, et al. 2108. In-vitro Activity of Five Novel Anti-Fungal Compounds Against Thirty-Two Strains of Talaromyces marneffei. Open Forum Infect Dis. 2023 Nov 27;10(Suppl 2):ofad500.1732.
- [3]. Shaw KJ, et al. In Vitro and In Vivo Evaluation of APX001A/APX001 and Other Gwt1 Inhibitors against Cryptococcus. Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00523-18. [Content Brief]
Keywords
