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Cat. No.: HY-N19876

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WF-5239

WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis.

For research use only. We do not sell to patients.

CAS No.: 91224-36-1
Formula: C₉H₉NO₂
Molecular Weight:163.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WF-5239 Chemical Structure

CAS No.: 91224-36-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

WF-5239 is a fungal metabolite can be found in Aspergillus fumigatus Fresenius. WF-5239 potently inhibits platelet aggregation. WF-5239 can be used for the research of pulmonary thrombosis^[1].

IC₅₀ & Target^[1]

Fungal Metabolite

All Endogenous Metabolite Isoforms :

In Vitro

WF-5239 (2 minutes) potently inhibits Arachidonic acid (HY-109590)- and Collagen (HY-NP003)-induced aggregation in rabbit platelet-rich plasma, with IC₅₀ values of 1.25 μg/mL and 5.0 μg/mL respectively, and has no meaningful activity against ADP- or Thrombin (HY-114164)-induced aggregation^[1].
WF-5239 (100 μg/mL) exhibits no antimicrobial activity against yeasts, fungi, bacteria, or mycobacteria at 100 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WF-5239 (3-30 mg/kg; i.p.; single dose) improves survival in a mouse model of Arachidonic acid-induced pulmonary thrombosis, with 80% survival observed at 30 mg/kg ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ddY (male, 15~20 g, pulmonary thrombosis induced by sodium Arachidonic acid slow tail vein injection)^[1]
Dosage:

3 mg/kg; 10 mg/kg; 30 mg/kg
Administration:

i.p.; single dose
Result:

Increased survival rate to 80% in 10 treated mice at 30 mg/kg.
Increased survival rate to 40% in 10 treated mice at 10 mg/kg.
Increased survival rate to 10% in 10 treated mice at 3 mg/kg.

Chemical Information

CAS No. 91224-36-1
Molecular Weight 163.17
Formula C₉H₉NO₂
SMILES

O=CN/C=C\C1=CC=C(C=C1)O
Structure Classification
- Phenols
- Monophenols
Initial Source
- Microorganisms
Aspergillus fumigatus
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Umehara K, et al. Studies on WF-5239, a new potent platelet aggregation inhibitor. J Antibiot (Tokyo). 1984;37(5):469-474. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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WF-5239

All Endogenous Metabolite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

WF-5239 Related Classifications

HY-N19876 Related Classifications