Aminocandin
Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp..
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- CAS. Nr.: 227472-48-2
- Formel: C56H79N9O14
- Molecular Weight:1102.28
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Fungal[1]
Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L[2].
Aminocandin shows half-life of 48-58 h[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Immunosuppressed male CD1 mice, Aspergillus fumigatus infection model[1]
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Dosage:10, 5, 1 and 0.25 mg/kg (IV) or 1 mg/kg (IP)
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Administration:IV or IP, once daily for 11 days
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Result:Increased the survival rate, 5 mg/kg i.v. yielded 100% survival following infection with AF91.
Chemical Information
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CAS. Nr. 227472-48-2
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Molecular Weight 1102.28
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Formel C56H79N9O14
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Synonyms
HMR 3270; IP960; NXL201
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Warn PA, et al. Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus. Int J Antimicrob Agents. 2010 Feb;35(2):146-51. [Content Brief]
[2]. Ghannoum MA, et al. Efficacy of aminocandin in the treatment of immunocompetent mice with haematogenously disseminated fluconazole-resistant candidiasis. J Antimicrob Chemother. 2007 Mar;59(3):556-9. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Aminocandin Related Classifications
HY-P0068 Related Classifications
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