Aminocandin  (Synonyms: HMR 3270; IP960; NXL201)

Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp.^[1].

Fungal^[1]

Aminocandin (HMR 3270) inhibits Fluconazole (HY-B0101)-resistant C. albicans strain MRL 648 with an MIC of 0.25 mg/L^[2].
Aminocandin shows half-life of 48-58 h^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aminocandin (1-10 mg/kg; i.v. or i.p.; once daily for 11 days) is highly effective in reducing mortality and organ burden in disseminated infection caused by ITC-susceptible and -resistant A. fumigatus in mice^[1].
Aminocandin (5 and 10 mg/kg; i.v.; once or twice a week for 4 weeks) is an effective addition to the arsenal of antifungal compounds for the treatment of candidiasis caused by Fluconazole (HY-B0101)-resistant C. albicans in immunocompetent mice^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1102.28

C₅₆H₇₉N₉O₁₄

227472-48-2

O=C([C@@H](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)CC(C=C3)=CC=C3O)=O)CO)N(C[C@@H]4C)[C@@](C(NCC(C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(C5=CC=C(C(C=C6)=CC=C6OCCCCCCCC)C=C5)=O)NCCN)=O)([H])[C@H]4O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.