227472-48-2
Chemical Structure
Aminocandin
Synonym(s): HMR 3270; IP960; NXL201
- CAS No.: 227472-48-2
- Formula:C56H79N9O14
- Molecular Weight:1102.28
IUPAC Name: N-((2R,9S,14aS,15S,16S,20S,25aS)-11-((2-aminoethyl)amino)-2,15-dihydroxy-23-((R)-1-hydroxy-2-(4-hydroxyphenyl)ethyl)-6-((R)-1-hydroxyethyl)-20-(hydroxymethyl)-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaa
InChIKey: UMNFJRNUJIBDSK-AQRFCNKBSA-N
SMILES: O=C([C@@H](NC([C@](NC([C@@](C[C@H]1O)([H])N(C1)C2=O)=O)([H])[C@H](O)CC(C=C3)=CC=C3O)=O)CO)N(C[C@@H]4C)[C@@](C(NCC(C[C@@H](C(N[C@@]2([H])[C@H](O)C)=O)NC(C5=CC=C(C(C=C6)=CC=C6OCCCCCCCC)C=C5)=O)NCCN)=O)([H])[C@H]4O
Biological Activity: Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp.[1].
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Aminocandin | Aminocandin (HMR 3270) is water-soluble antifungal agent of the echinocandin class with excellent activity against Aspergillus and Candida spp.. | |||||||||||||||||||||
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References
- [1]. Warn PA, et al. Activity of aminocandin (IP960; HMR3270) compared with amphotericin B, itraconazole, caspofungin and micafungin in neutropenic murine models of disseminated infection caused by itraconazole-susceptible and -resistant strains of Aspergillus fumigatus. Int J Antimicrob Agents. 2010 Feb;35(2):146-51. [Content Brief]
