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Pathways Recommended:	Vitamin D Related/Nuclear Receptor

Results for "

Vitamin A metabolite

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Drug Metabolite (19) Endogenous Metabolite (56) VD/VDR (32) VKOR (1) Apoptosis (3) Aryl Hydrocarbon Receptor (1) Autophagy (7) Bacterial (2) Biochemical Assay Reagents (2) Calcium Channel (2) Caspase (1) Cytochrome P450 (2) DNA/RNA Synthesis (1) Drug Derivative (3) Drug Intermediate (3) Drug Isomer (1) Environmental Pollutants (2) Isotope-Labeled Compounds (28) LXR (1) Mitochondrial Metabolism (2) NF-κB (1) Organoid (1) PARP (1) PPAR (8) RAR/RXR (8) Reactive Oxygen Species (ROS) (1) Reference Standards (15) Sodium Channel (1) Thyroid Hormone Receptor (2) TNF Receptor (1) Topoisomerase (1) Transketolase (1)
By Research Areas:	Cancer (19) Endocrinology (1) Infection (3) Inflammation/Immunology (9) Metabolic Disease (55) Neurological Disease (6)

By Targets:

Drug Metabolite (19)

Endogenous Metabolite (56)

VD/VDR (32)

VKOR (1)

Apoptosis (3)

Aryl Hydrocarbon Receptor (1)

Autophagy (7)

Bacterial (2)

Biochemical Assay Reagents (2)

Calcium Channel (2)

Caspase (1)

Cytochrome P450 (2)

DNA/RNA Synthesis (1)

Drug Derivative (3)

Drug Intermediate (3)

Drug Isomer (1)

Environmental Pollutants (2)

Isotope-Labeled Compounds (28)

LXR (1)

Mitochondrial Metabolism (2)

NF-κB (1)

Organoid (1)

PARP (1)

PPAR (8)

RAR/RXR (8)

Reactive Oxygen Species (ROS) (1)

Reference Standards (15)

Sodium Channel (1)

Thyroid Hormone Receptor (2)

TNF Receptor (1)

Topoisomerase (1)

Transketolase (1)

By Research Areas:

Cancer (19)

Endocrinology (1)

Infection (3)

Inflammation/Immunology (9)

Metabolic Disease (55)

Neurological Disease (6)

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: VD/VDR Drug Metabolite Endogenous Metabolite VKOR

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-14649

Retinoic acid Maximum Cited Publications 127 Publications Verification Vitamin A acid; all-trans-Retinoic acid; ATRA	Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-10002

Calcitriol 65+ Cited Publications 1,25-DihydroxyVitamin D3	Drug Metabolite VD/VDR Endogenous Metabolite	Cancer
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-B1342

Vitamin A Vitamin A1; all-trans-Retinol	Environmental Pollutants Endogenous Metabolite	Metabolic Disease
Vitamin A (Vitamin A1) is an endogenous metabolite.

HY-W004500

All-trans-retinal 3 Publications Verification	Endogenous Metabolite Apoptosis	Metabolic Disease
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

HY-W015851

(R)-3-Hydroxybutanoic acid sodium 5+ Cited Publications (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium	Endogenous Metabolite	Metabolic Disease
(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .

HY-W051723

(R)-3-Hydroxybutanoic acid 5+ Cited Publications (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid	Endogenous Metabolite	Metabolic Disease
(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .

HY-10003

Alfacalcidol 5 Publications Verification 1-hydroxycholecalciferol; 1.alpha.-HydroxyVitamin D3	Environmental Pollutants VD/VDR	Metabolic Disease
Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis .

HY-137808

Succinyl-Coenzyme A sodium 3 Publications Verification Succinyl-CoA sodium	Endogenous Metabolite	Neurological Disease Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-14649R

Retinoic acid (Standard) Maximum Cited Publications 127 Publications Verification Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard)	Reference Standards RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-32343

Secalciferol 5+ Cited Publications (24R)-24,25-DihydroxyVitamin D3	Endogenous Metabolite VD/VDR	Metabolic Disease Inflammation/Immunology
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-W015240

N-Acetyl-L-glutamic acid	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases .

HY-N7495

all-trans-Anhydro Retinol AnhydroVitamin A	Drug Metabolite	Metabolic Disease
all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body .

HY-134240

L-Threonic acid magnesium Magnesium L-threonate	NF-κB TNF Receptor	Neurological Disease Inflammation/Immunology
L-Threonic acid magnesium (Magnesium L-threonate) is the enantiomer of Threonic acid and the metabolite of vitamin C (HY-B0166). L-Threonic acid magnesium is a magnesium supplementation, that improves the brain magnesium concentration, inhibits the activation of TNF-α/NF-κB signaling pathway. L-Threonic acid magnesium can be used in research of Alzheimer’s disease. L-Threonic acid magnesium is orally active .

HY-32349

Ercalcidiol 2 Publications Verification 25-Hydroxy Vitamin D2	VD/VDR Endogenous Metabolite	Metabolic Disease
Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

HY-112023

Lumisterol 3 (purity>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Endogenous Metabolite	Metabolic Disease
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D .

HY-W017464

NAPQI N-Acetyl-4-benzoquinone Imine	Drug Metabolite Endogenous Metabolite	Metabolic Disease
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-76814

Calcitriol-d6	VD/VDR Isotope-Labeled Compounds	Metabolic Disease
Calcitriol-d₆ is the deuterium labeled Calcitriol. Calcitriol is the active metabolite of vitamin D3 and an agonist of the vitamin D receptor (VDR) .

HY-128742

Thiamine monophosphate chloride dihydrate	Endogenous Metabolite Drug Derivative	Metabolic Disease
Thiamine monophosphate chloride dihydrate is a vitamin B1 (HY-A0100) metabolite and thiamine precursor. Thiamine monophosphate chloride dihydrate is absorbable in vivo and can be converted into thiamine. Thiamine monophosphate chloride dihydrate can be used as a food additive .

HY-107494A

all-trans-4-Oxoretinoic acid 1 Publications Verification all-trans 4-Keto Retinoic Acid	Endogenous Metabolite	Metabolic Disease
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-13332

Calcifediol-d6 25-hydroxy Vitamin D3-d₆	Isotope-Labeled Compounds VD/VDR	Metabolic Disease
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-B1746

Pyridoxamine 5′-phosphate	Endogenous Metabolite	Neurological Disease
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of Pyridoxal 5'-?phosphate monohydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-76801

24, 25-Dihydroxy VD2 2 Publications Verification 24,25-Dihydroxy Vitamin D2	Drug Metabolite Endogenous Metabolite	Metabolic Disease
24,25-Dihydroxy VD2 (24,25-Dihydroxy vitamin D2) is a hydroxylated metabolite and derivative of Vitamin D2 HY-76542 (HY-76542) .

HY-15157

Calcitetrol 1α, 24, 25-Trihydroxy VD3	VD/VDR Drug Metabolite	Infection
Calcitetrol (1α, 24, 25-Trihydroxy VD3), a Vitamin D3 (HY-15398) metabolite, is the hormonally active form of vitamin D. Calcitetrol participates in regulation of Treg cells. Calcitetrol can be used for the research of Toxoplasma gondii infection .

HY-N10508

Calcitroic acid	Drug Metabolite VD/VDR	Metabolic Disease Cancer
Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity .

HY-14649S4

Retinoic acid-d5 Vitamin A acid-d₅; all-trans-Retinoic acid-d₅; ATRA-d₅	Isotope-Labeled Compounds RAR/RXR PPAR Endogenous Metabolite Autophagy	Cancer
Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-10002R

Calcitriol (Standard) 1,25-DihydroxyVitamin D3 (Standard)	Drug Metabolite Reference Standards VD/VDR Endogenous Metabolite	Cancer
Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-10002A

(1S)-Calcitriol 1α,25-Dihydroxy-3-epi-Vitamin-D3	VD/VDR	Others
(1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D₃ (1α,25(OH)₂D₃). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion .

HY-77278

25-Hydroxytachysterol3	VD/VDR Aryl Hydrocarbon Receptor LXR PPAR	Others
25-Hydroxytachysterol3 is the metabolite of Vitamin D3 (HY-15398). 25-Hydroxytachysterol3 inhibits the proliferation of epidermal keratinocytes and dermal fibroblasts, stimulates the expression of differentiation- and antioxidant-related genes in keratinocytes. 25-Hydroxytachysterol3 activates vitamin D receptor (VDR) and aryl hydrocarbon receptor (AhR), liver X receptor α/β (LXR α/β) and peroxisome proliferator-activated receptor γ (PPARγ), stimulates the expression of CYP24A1 .

HY-W015851S2

(R)-3-Hydroxybutanoic acid-13C4 sodium (R)-(-)-3-Hydroxybutanoic acid-13C4 sodium; (R)-3-Hydroxybutyric acid-13C4 sodium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(R)-3-Hydroxybutanoic acid- ¹³C₄ sodium is a ¹³C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .

HY-W654002

(3R)-3-Hydroxybutyric acid-1-13C	Isotope-Labeled Compounds Endogenous Metabolite	Others
(3R)-3-Hydroxybutyric acid-1- ¹³C is ¹³C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .

HY-148285

Succinyl CoA Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A	Endogenous Metabolite	Metabolic Disease
Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-10002S

Calcitriol-13C3 1,25-DihydroxyVitamin D3-¹³C₃	Isotope-Labeled Compounds Sodium Channel	Neurological Disease
Calcitriol- ¹³C₃ is the ¹³C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-N10479

Chorismic acid	DNA/RNA Synthesis Drug Intermediate Endogenous Metabolite Bacterial	Infection
Chorismic acid is a precursor for the biosynthesis of aromatic amino acids and vitamins, as well as a key metabolite in tRNA modification. Chorismic acid is a critical metabolite for the synthesis of cmo ⁵U. Deficiency of Chorismic acid inhibits the formation of cmo ⁵U and mcmo ⁵U. Chorismic acid can be used in studies of S. typhimurium and E. coli infections .\n

HY-107494

13-cis-4-Oxoretinoic acid 4-Keto 13-cis-retinoic acid; 4-Oxoisotretinoin; Ro 22-6595	Endogenous Metabolite	Others
13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .

HY-15830

25,26-Dihydroxyvitamin D3 25,26-Dihydroxycholecalciferol	VD/VDR Drug Metabolite Drug Derivative Calcium Channel	Metabolic Disease
25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia .

HY-113164

Vitamin K1 2,3-epoxide	Endogenous Metabolite	Others
Vitamin K1 2,3-epoxide is an inactive metabolite form of Vitamin K1 (HY-N0684), which is reduced to active vitamin by microsomal epoxide reductase in the vitamin K epoxide cycle. Vitamin K1 2,3-epoxide is involved in blood clotting .

HY-13292

Impurity B of Calcitriol 1β,25-DihydroxyVitamin-D3; 1-Epicalcitriol	VD/VDR	Cancer
Impurity B of Calcitriol, Calcitriol(1,25-Dihydroxyvitamin D3; Rocaltrol ) is the hormonally active form of vitamin D, Calcitriol is the active metabolite of vitamin D3 that activates the vitamin D receptor (VDR).

HY-32349S

Ercalcidiol-d3 25-Hydroxy Vitamin D2-d₃	Isotope-Labeled Compounds Endogenous Metabolite VD/VDR	Metabolic Disease
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-32349R

Ercalcidiol (Standard) 25-Hydroxy Vitamin D2 (Standard)	Reference Standards VD/VDR Endogenous Metabolite	Metabolic Disease
Ercalcidiol (Standard) is the analytical standard of Ercalcidiol. This product is intended for research and analytical applications. Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-10002S1

Calcitriol-d3 1,25-DihydroxyVitamin D3-d₃	VD/VDR Endogenous Metabolite	Cancer
Calcitriol-d₃ is the deuterium labeled Calcitriol . Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist .

HY-133879

Calcitriol lactone 1α,25-DihydroxyVitamin D3-26,23-lactone	Endogenous Metabolite	Others Inflammation/Immunology
Calcitriol lactone (1α,25-Dihydroxyvitamin D3-26,23-lactone) is a metabolite of vitamin D3. Calcitriol lactone is the active form of vitamin D and affects bone health, cell differentiation, immune function .

HY-B1342A

13-cis-Vitamin A 13-cis-Vitamin A1; 13-cis-Retinol	Drug Isomer Drug Metabolite	Metabolic Disease
13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter .

HY-B0228S10

(R)-3-Hydroxybutanoic acid-13C2 sodium (R)-(-)-3-Hydroxybutanoic acid-13C2 sodium; (R)-3-Hydroxybutyric acid-13C2 sodium	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
(R)-3-Hydroxybutanoic acid- ¹³C₂ sodium is the ¹³C labeled (R)-3-Hydroxybutanoic acid sodium (HY-W015851). (R)-3-Hydroxybutanoic acid sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .

HY-107494R

13-cis-4-Oxoretinoic acid (Standard) 4-Keto 13-cis-retinoic acid (Standard); 4-Oxoisotretinoin (Standard); Ro 22-6595 (Standard)	Reference Standards Endogenous Metabolite	Others
13-cis-4-Oxoretinoic acid (Standard) is the analytical standard of 13-cis-4-Oxoretinoic acid (HY-107494). This product is intended for research and analytical applications. 13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .

HY-128606

Thiamine diphosphate analog 1	Endogenous Metabolite Transketolase	Neurological Disease Metabolic Disease
Thiamine diphosphate analog 1 is an analog of thiamine diphosphate. Thiamine diphosphate is the active metabolite of vitamin B₁ in organisms. Thiamine diphosphate targets ThDP-dependent enzymes such as transketolase and pyruvate dehydrogenase complex, acting as an essential coenzyme to exert an activating effect. Thiamine diphosphate assists in catalytic reactions in free form and initiates the catalytic cycles of various glucose-metabolizing enzymes. Thiamine diphosphate serves as a diagnostic biomarker and protective factor for Alzheimer's disease. Thiamine diphosphate can be used in research related to metabolism and Alzheimer's disease .

HY-W015240S

N-Acetyl-L-glutamic acid-d5	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease Inflammation/Immunology
N-Acetyl-L-glutamic acid-d₅ is the deuterium labeled N-Acetyl-L-glutamic acid (HY-W015240). N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases .

HY-75041

Calcitriol Impurities A	Biochemical Assay Reagents	Metabolic Disease
Calcitriol Impurities A is an impurity of Calcitriol (HY-10002). Calcitriol is the active metabolite of vitamin D3 and can activate the vitamin D receptor.

HY-10003AR

1α-Hydroxy-3-epi-vitamin D3 (Standard)	Thyroid Hormone Receptor Reference Standards	Metabolic Disease
1α-Hydroxy-3-epi-vitamin D3 (Standard) is the analytical standard of 1α-Hydroxy-3-epi-vitamin D3 (HY-10003A). This product is intended for research and analytical applications. 1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone (PTH) secretion .

HY-A0058

Retinyl glucoside Retinyl β-D-glucoside	Drug Metabolite	Metabolic Disease
Retinyl-β-D-glucoside is a naturally occurring and biologically active metabolites of vitamin A, which are found in fish and mammals.

HY-W017519

2-Quinoxalinol Quinoxalin-2-one	Drug Intermediate	Others
2-Quinoxalinol (2-hydroxyquinoxaline) is a 2-hydroxylated quinoxaline that possesses photocatalytic activity and interacts with various compounds, such as antioxidant vitamins and aromatic metabolites, including neurotransmitters and the pineal hormone melatonin .

Cat. No.	Product Name

HY-L123

Human Metabolite Library

6,717 compounds

Human metabolism is an integral part of cellular function that reflects individual differences in health, disease, diet, and lifestyle. Many health conditions such as obesity, diabetes, hypertension, heart disease, and cancer are associated with abnormal metabolic states. In the pathological state of the human body, metabolic pathways are significantly altered, resulting in aberrant levels of intermediates or end-products that can be viewed as potential diagnostic biomarkers or even therapeutic targets. Therefore, detection, identification and quantification of human metabolites are very important for drug metabolism research in drug development.

MCE offers a unique collection of 6,717 human metabolites, including endogenous metabolites and exogenous metabolites, covering multiple structure types, such as lipids, amino acids, nucleic acids, carbohydrates, organic acids, biogenic amines, vitamins,. MCE Human Metabolites Library is a helpful tool for studying the relationship between diseases and metabolism.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-14649

Retinoic acid Maximum Cited Publications 127 Publications Verification Vitamin A acid; all-trans-Retinoic acid; ATRA	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Whitening Agent Cosmetic Research Endogenous metabolite Disease Research Fields Source Classification Cancer	Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy
Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-10002

Calcitriol 65+ Cited Publications 1,25-DihydroxyVitamin D3	Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Drug Metabolite VD/VDR Endogenous Metabolite
Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-B1342

Vitamin A Vitamin A1; all-trans-Retinol	Structural Classification Natural Products Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Endogenous Metabolite
Vitamin A (Vitamin A1) is an endogenous metabolite.

HY-W004500

All-trans-retinal 3 Publications Verification	Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Terpenoids Other Diseases Diterpenoids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis
All-trans-retinal is an vitamin A metabolite in the retina, and is produced following photo-isomerization of the visual chromophore 11-cis-Retinal. All-trans-retinal is cleared from photoreceptors by ATP-binding cassette transporter (ABCA4) and all-trans-retinol dehydrogenase (RDH). All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis .

HY-W015851

(R)-3-Hydroxybutanoic acid sodium 5+ Cited Publications (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium	Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .

HY-W051723

(R)-3-Hydroxybutanoic acid 5+ Cited Publications (R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid	Immune System Disorder Classification of Application Fields Anti-aging Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields Cardiovascular System Disorder Source Classification	Endogenous Metabolite
(R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .

HY-137808

Succinyl-Coenzyme A sodium 3 Publications Verification Succinyl-CoA sodium	Structural Classification Natural Products Neurological Disease Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Succinyl CoA (Succinyl-coenzyme A) sodium is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA sodium is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA sodium acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA sodium insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA sodium can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-14649R

Retinoic acid (Standard) Maximum Cited Publications 127 Publications Verification Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard)	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Reference Standards RAR/RXR PPAR Endogenous Metabolite Autophagy
Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.

HY-32343

Secalciferol 5+ Cited Publications (24R)-24,25-DihydroxyVitamin D3	Classification of Application Fields Endogenous metabolite Inflammation/Immunology Disease Research Fields Steroids Source Classification	Endogenous Metabolite VD/VDR
Secalciferol ((24R)-24,25-Dihydroxyvitamin D3) is the major active metabolite of Vitamin D. Secalciferol activates vitamin D receptor (VDR) with an EC₅₀ value of 150 nM. Secalciferol is involved in a wide range of biological functions such as calcium homeostasis, cellular differentiation and proliferation processes, as well as other functions related to the immune system, which is promising for research of rickets, osteomalacia, hypercalcemia and autoimmune disorders .

HY-W015240

N-Acetyl-L-glutamic acid	Microorganisms Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases .

HY-N7495

all-trans-Anhydro Retinol AnhydroVitamin A	Classification of Application Fields Terpenoids Metabolic Disease Diterpenoids Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite
all-trans-Anhydro Retinol (Anhydrovitamin A) is an orally active degradation product formed by the dehydration of vitamin A alcohol and its esters under conditions such as acidic catalysis or hydroxylic solvents, with a biological activity only 0.4% of that of Vitamin A (HY-B1342). In rats, all-trans-Anhydro Retinol can be metabolized into hydroxy derivatives and their esters, but it cannot be converted into Vitamin A (HY-B1342) and has a low storage capacity in the body .

HY-32349

Ercalcidiol 2 Publications Verification 25-Hydroxy Vitamin D2	Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	VD/VDR Endogenous Metabolite
Ercalcidiol is a metabolite of vitamin D₂, is regarded as an indicator of vitamin D nutritional status.

HY-112023

Lumisterol 3 (purity>90%) 9β,10α-Cholesta-5,7-dien-3β-ol; Cholecalciferol EP Impurity C	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
Lumisterol 3 (>90%) (9β,10α-Cholesta-5,7-dien-3β-ol) is a normal human secosterooid metabolite from the class of vitamin D3 photoisomer derivatives. Lumisterol 3 (>90%) is used in the preparation of vitamin D .

HY-W017464

NAPQI N-Acetyl-4-benzoquinone Imine	Alkaloids Classification of Application Fields Other Alkaloids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Drug Metabolite Endogenous Metabolite
NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-128742

Thiamine monophosphate chloride dihydrate	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Drug Derivative
Thiamine monophosphate chloride dihydrate is a vitamin B1 (HY-A0100) metabolite and thiamine precursor. Thiamine monophosphate chloride dihydrate is absorbable in vivo and can be converted into thiamine. Thiamine monophosphate chloride dihydrate can be used as a food additive .

HY-107494A

all-trans-4-Oxoretinoic acid 1 Publications Verification all-trans 4-Keto Retinoic Acid	Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-B1746

Pyridoxamine 5′-phosphate	Alkaloids Human Gut Microbiota Metabolites Neurological Disease Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Pyridoxamine 5′-phosphate is the active form of vitamin B6 bound to phosphoric acid. Pyridoxamine 5′-phosphate is the aminated form of Pyridoxal 5'-?phosphate monohydrate (HY-W011727A) and as co-factor of a variety of enzymes central metabolite, potent antioxidant, vitamin B6 vitamer and enzyme substrate. Pyridoxamine 5′-phosphate can be interconverted with pyridoxal 5'-phosphate hydrate .

HY-N10508

Calcitroic acid	Ketones, Aldehydes, Acids Endogenous metabolite	Drug Metabolite VD/VDR
Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity .

HY-10002R

Calcitriol (Standard) 1,25-DihydroxyVitamin D3 (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Drug Metabolite Reference Standards VD/VDR Endogenous Metabolite
Calcitriol (Standard) is the analytical standard of Calcitriol. This product is intended for research and analytical applications. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-148285

Succinyl CoA Succinyl-coenzyme A; S-(Hydrogen succinyl)coenzyme A	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
Succinyl CoA (Succinyl-coenzyme A) is a pivotal intermediate metabolite in the tricarboxylic acid cycle and a key coenzyme A metabolite. Succinyl CoA is biosynthesized from α-ketoglutarate or propionyl-CoA. Succinyl CoA acts as a critical precursor and substrate for heme biosynthesis and gluconeogenesis. Succinyl CoA insufficiency caused by cobalamin deficiency is directly linked to growth retardation, impaired heme synthesis, tissue glycine accumulation and neurological abnormalities. Succinyl CoA can be used in research on metabolic, neurological, and hematological abnormalities (such as porphyria) caused by nutritional vitamin B12 deficiency (leading to a lack of Succinyl-Coenzyme A synthesis) .

HY-N10479

Chorismic acid	Microorganisms Ketones, Aldehydes, Acids Source Classification	DNA/RNA Synthesis Drug Intermediate Endogenous Metabolite Bacterial
Chorismic acid is a precursor for the biosynthesis of aromatic amino acids and vitamins, as well as a key metabolite in tRNA modification. Chorismic acid is a critical metabolite for the synthesis of cmo ⁵U. Deficiency of Chorismic acid inhibits the formation of cmo ⁵U and mcmo ⁵U. Chorismic acid can be used in studies of S. typhimurium and E. coli infections .\n

HY-15830

25,26-Dihydroxyvitamin D3 25,26-Dihydroxycholecalciferol	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	VD/VDR Drug Metabolite Drug Derivative Calcium Channel
25,26-Dihydroxyvitamin D3 (25,26-Dihydroxycholecalciferol) is a dihydroxylated derivative and metabolite of Vitamin D3 (HY-15398). 25,26-Dihydroxyvitamin D3 moderately increases serum calcium levels when the initial serum calcium level is low. 25,26-Dihydroxyvitamin D3 promotes intestinal calcium absorption in vitamin D-deficient rats fed a low-calcium diet. 25,26-Dihydroxyvitamin D3 is applicable to research related to osteomalacia .

HY-32349R

Ercalcidiol (Standard) 25-Hydroxy Vitamin D2 (Standard)	Structural Classification Endogenous metabolite Steroids Source Classification	Reference Standards VD/VDR Endogenous Metabolite
Ercalcidiol (Standard) is the analytical standard of Ercalcidiol. This product is intended for research and analytical applications. Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-B1342A

13-cis-Vitamin A 13-cis-Vitamin A1; 13-cis-Retinol	Natural Products Endogenous metabolite Source Classification	Drug Isomer Drug Metabolite
13-cis-Vitamin A (13-cis-Vitamin A1) is the 13-cis-isomer of Vitamin A (HY-B1342), which is an active metabolite found in butter .

HY-32350R

Ercalcitriol (Standard) 1α,25-Dihydroxy Vitamin D2 (Standard)	Natural Products Endogenous metabolite Source Classification	Reference Standards VD/VDR Drug Metabolite Endogenous Metabolite
Ercalcitriol (Standard) is the analytical standard of Ercalcitriol. This product is intended for research and analytical applications. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.

HY-145806

13-cis-Retinyl acetate 13-cis-Retinol acetate; 13-cis-Vitamin A acetate	Classification of Application Fields Terpenoids Diterpenoids Endogenous metabolite Disease Research Fields Endocrinology Source Classification	Endogenous Metabolite
13-cis-Retinyl acetate (13-cis-Retinol acetate; 13-cis-Vitamin A acetate) is a 13-cis isomer formed by Retinyl acetate. 13-cis-Retinyl acetate is an active metabolite of vitamin A .

HY-107494AR

all-trans-4-Oxoretinoic acid (Standard) all-trans 4-Keto Retinoic Acid (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
all-trans-4-Oxoretinoic acid (Standard) is the analytical standard of all-trans-4-Oxoretinoic acid. This product is intended for research and analytical applications. all-trans-4-Oxoretinoic acid, an active metabolite of vitamin A, induces gene transcription via binding to nuclear retinoic acid receptors (RARs).

HY-N9923

2-C-Methyl-D-erythritol 4-phosphate	Structural Classification Human Gut Microbiota Metabolites Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Bacterial
2-C-Methyl-D-erythritol 4-phosphate is a metabolite intermediate exclusive to the non-mevalonate MEP pathway, predominantly found in prokaryotes, serving as a precursor for the synthesis of isoprenoids and non-isoprenoids, including vitamins; its absence in humans makes it a promising target for the development of bacterium-specific drugs aimed at treating infectious diseases.

HY-128742R

Thiamine monophosphate chloride dihydrate (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Drug Derivative
Thiamine monophosphate chloride dihydrate (Standard) is an analytical standard for Thiamine monophosphate chloride dihydrate (HY-128742). This product is intended for use in research and analytical applications. Thiamine monophosphate chloride dihydrate is a vitamin B1 (HY-A0100) metabolite and thiamine precursor. Thiamine monophosphate chloride dihydrate is absorbable in vivo and can be converted into thiamine. Thiamine monophosphate chloride dihydrate can be used as a food additive .

HY-W051723R

(R)-3-Hydroxybutanoic acid (Standard) (R)-(-)-3-Hydroxybutanoic acid (Standard); (R)-3-Hydroxybutyric acid (Standard)	Structural Classification Immune System Disorder Ketones, Aldehydes, Acids Disease markers Endocrine diseases Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Source Classification	Reference Standards Endogenous Metabolite
(R)-3-Hydroxybutanoic acid (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid. This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones[1][2].

HY-W015851R

(R)-3-Hydroxybutanoic acid sodium (Standard) (R)-(-)-3-Hydroxybutanoic acid sodium (Standard); (R)-3-Hydroxybutyric acid sodium (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
(R)-3-Hydroxybutanoic acid (sodium) (Standard) is the analytical standard of (R)-3-Hydroxybutanoic acid (sodium). This product is intended for research and analytical applications. (R)-3-Hydroxybutanoic acid ((R)-3-Hydroxybutyric acid) sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones[1][2].

HY-W015240R

N-Acetyl-L-glutamic acid (Standard)	Microorganisms Amino acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
N-Acetyl-L-glutamic acid (Standard) is the analytical standard of N-Acetyl-L-glutamic acid (HY-W015240). This product is intended for research and analytical applications. N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases .

HY-N17652

13′-Hydroxy-δ-tocopherol	Structural Classification Monophenols Garcinia kola Heckel Guttiferae Phenols Plants Source Classification	Apoptosis Mitochondrial Metabolism
13′-Hydroxy-δ-tocopherol is a metabolite of long-chain vitamin E. 13′-Hydroxy-δ-tocopherol can induces cells apoptosis and minor reduction in mitochondrial membrane potential. 13′-Hydroxy-δ-tocopherol can be used for the research of hepatocellular carcinoma .

HY-W017464R

NAPQI (Standard) N-Acetyl-4-benzoquinone Imine (Standard)	Structural Classification Alkaloids Other Alkaloids Endogenous metabolite Source Classification	Drug Metabolite Reference Standards Endogenous Metabolite
NAPQI (Standard) is the analytical standard of NAPQI (HY-W017464). This product is intended for research and analytical applications. NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-159201

24-Oxo-25-hydroxyvitamin D3	Structural Classification Animals Terpenoids Diterpenoids Source Classification	Calcium Channel
24-Oxo-25-hydroxyvitamin D3 is a vitamin D3 metabolite and an intermediate in the renal mitochondrial side-chain oxidation pathway. 24-Oxo-25-hydroxyvitamin D3 enhances intestinal calcium transport in rats . 24-Oxo-25-hydroxyvitamin D3 can be used in studies related to X-linked hypophosphatemic rickets .

HY-N17653

13'-Carboxy-δ-tocopherol	Structural Classification Ketones, Aldehydes, Acids Garcinia kola Heckel Guttiferae Phenols Plants Source Classification	Apoptosis Mitochondrial Metabolism Reactive Oxygen Species (ROS) Caspase PARP Drug Metabolite
13'-Carboxy-δ-tocopherol is a metabolite of long-chain vitamin E.13'-Carboxy-δ-tocopherol exhibits antiproliferative properties in cancer cells. 13'-Carboxy-δ-tocopherol activates caspase-3, caspase-9, causes PARP-1 cleavage, reduces mitochondrial membrane potential, increases ROS formation, and drives apoptosis.13'-Carboxy-δ-tocopherol can be used for the research of hepatocellular carcinoma .

Cat. No.	Product Name	Chemical Structure

HY-76814

Calcitriol-d6
Calcitriol-d₆ is the deuterium labeled Calcitriol. Calcitriol is the active metabolite of vitamin D3 and an agonist of the vitamin D receptor (VDR) .

HY-13332

Calcifediol-d6
Calcifediol-d₆ is the deuterium labeled Calcifediol. Calcifediol, a major circulating metabolite of vitamin D3, is a potent VDR ligand .

HY-14649S4

Retinoic acid-d5

Retinoic acid-d₅ is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with K_d of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-W015851S2

(R)-3-Hydroxybutanoic acid-13C4 sodium
(R)-3-Hydroxybutanoic acid- ¹³C₄ sodium is a ¹³C labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .

HY-W654002

(3R)-3-Hydroxybutyric acid-1-13C
(3R)-3-Hydroxybutyric acid-1- ¹³C is ¹³C labeled (R)-3-Hydroxybutanoic acid. (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones .

HY-10002S

Calcitriol-13C3
Calcitriol- ¹³C₃ is the ¹³C-labeled Calcitriol. Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-32349S

Ercalcidiol-d3
Ercalcidiol-d₃ is the deuterium labeled Ercalcidiol. Ercalcidiol is a metabolite of Vitamins D2. Ercalcidiol can be used as an indicator of vitamins D status .

HY-10002S1

Calcitriol-d3
Calcitriol-d₃ is the deuterium labeled Calcitriol . Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist .

HY-B0228S10

(R)-3-Hydroxybutanoic acid-13C2 sodium
(R)-3-Hydroxybutanoic acid- ¹³C₂ sodium is the ¹³C labeled (R)-3-Hydroxybutanoic acid sodium (HY-W015851). (R)-3-Hydroxybutanoic acid sodium is a metabolite converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid sodium can function as a nutrition source, and as a precursor for vitamins, antibiotics and pheromones .

HY-W015240S

N-Acetyl-L-glutamic acid-d5

N-Acetyl-L-glutamic acid-d₅ is the deuterium labeled N-Acetyl-L-glutamic acid (HY-W015240). N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases .

HY-10003S

Alfacalcidol-d7
Alfacalcidol-d₇ is the deuterium labeled Alfacalcidol. Alfacalcidol (1-hydroxycholecalciferol) is a vitamin D active metabolites, acts as a non-selective VDR activator medication, and widely be used in the management of osteoporosis .

HY-14649S2

11-cis-Retinoic Acid-d5

11-cis-Retinoic Acid-d₅ is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].

HY-14649S3

Retinoic acid-d6

Retinoic acid-d₆ is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].

HY-N0684AS

cis-Vitamin K1-d7
cis-Vitamin K1-d₇ is the deuterium labeled cis-Vitamin K1, is an endogenous metabolite of Vitamin K .

HY-142140S

3-epi-25-Hydroxy Vitamin D3-d6
3-epi-25-Hydroxy Vitamin D3-d₆ is the deuterium labeled 3-epi-25-Hydroxy Vitamin D3 (HY-142140) . 3-epi-25-Hydroxy Vitamin D3 is the vitamin D metabolite, while vitamin D metabolism highly dependent on macrophage polarization. The C3-epimerase pathway for vitamin D is active in macrophages .

HY-32350S

Ercalcitriol-13C,d3
Ercalcitriol- ¹³C,d₃ is the ¹³C- and deuterium labeled Ercalcitriol. Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2.

HY-32343S

Secalciferol-d6
Secalciferol-d₆ is the deuterium labeled Secalciferol. Secalciferol is a metabolite of Vitamin D, a possibly anti-inflammatory steroid which is involved in bone ossification .

HY-14649S5

Retinoic acid-d3

Retinoic acid-d₃ is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-W744265

NAPQI-d3

NAPQI-d₃ (N-Acetyl-4-benzoquinone Imine-d₃) is the deuterium labeled NAPQI (HY-W017464). NAPQI is the toxic metabolite of Acetaminophen (HY-66005). NAPQI is also an inhibitor of enzymes in the vitamin K cycle. NAPQI is rapidly detoxified by glutathione (GSH), but in situations of GSH deficiency, excess NAPQI reacts with cysteine residues in proteins, causing cell death and toxicity in the liver .

HY-14649S6

Retinoic acid-d3-1

Retinoic acid-d₃-1 is the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC₅₀s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .

HY-107494S3

13-cis-4-Oxoretinoic acid-d6
13-cis-4-Oxoretinoic acid-d₆ (4-Keto 13-cis-retinoic acid-d₆; 4-Oxoisotretinoin-d₆; Ro 22-6595-d₆) is the deuterium labeled 13-cis-4-Oxoretinoic acid (HY-107494). 13-cis-4-Oxoretinoic acid (4-Keto 13-cis-retinoic acid) is a metabolite of vitamin A in human plasma .

HY-W015240S1

N-Acetyl-L-glutamic acid-d4

N-Acetyl-L-glutamic acid-d₄ is the deuterium labeled N-Acetyl-L-glutamic acid (HY-W015240). N-Acetyl-L-glutamic acid is a type of glutamic acid that can serve as a component of cell culture media. When combined with media containing inorganic salts, carbohydrates, vitamins, and amino acids, N-Acetyl-L-glutamic acid plays roles in promoting cell growth, enhancing antibody production, etc. N-Acetyl-L-glutamic acid is also an endogenous metabolite that can be found in the brain. Additionally, as an IgE blocker, N-Acetyl-L-glutamic acid can be used in the research of allergic diseases .

HY-32349S2

Ercalcidiol-d9
Ercalcidiol-d₉ (25-Hydroxy Vitamin D2-d₉) is the deuterium labeled Ercalcidiol (HY-32349). Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-32349S3

Ercalcidiol-13C3
Ercalcidiol- ¹³C₃ (25-Hydroxy Vitamin D2- ¹³C3) is the ¹³C-labeled Ercalcidiol (HY-32349). Ercalcidiol is a metabolite of vitamin D2, is regarded as an indicator of vitamin D nutritional status.

HY-10002S2

Calcitriol-d9
Calcitriol-d₉ (1,25-Dihydroxyvitamin D3-d₉) is the deuterium labeled Calcitriol (HY-10002). Calcitriol is the most active metabolite of vitamin D and also a vitamin D receptor (VDR) agonist.

HY-10002AS2

(1S)-Calcitriol-d6

(1S)-Calcitriol-d₆ (1α,25-Dihydroxy-3-epi-vitamin D3-d₆) is the deuterium labeled (1S)-Calcitriol (HY-10002A). (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion .

HY-10002AS

(1S)-Calcitriol-d3

(1S)-Calcitriol-d₃ (1α,25-Dihydroxy-3-epi-vitamin D3-d₃) is the deuterium labeled (1S)-Calcitriol (HY-10002A). (1S)-Calcitriol (1α,25-Dihydroxy-3-epi-vitamin-D3) is a natural metabolite of 1α,25-dihydroxyvitamin D3 (1α,25(OH)2D3). (1S)-Calcitriol exhibits potent vitamin D receptor (VDR)-mediated actions such as inhibition of keratinocyte growth or suppression of parathyroid hormone secretion .

HY-N10508S

Calcitroic acid-13C
Calcitroic acid- ¹³C is the ¹³C-labeled Calcitroic acid (HY-N10508). Calcitroic acid is a vitamin D receptor (VDR) agonist that can activate VDR-mediated transcription. Calcitroic acid is the main metabolite of 1,25-dihydroxyvitamin D3, with the highest concentrations found in the liver and mucosa of mice, and it has metabolic stability and very low toxicity .

HY-W051723S2

(R)-3-Hydroxybutanoic acid-d
(R)-3-Hydroxybutanoic acid-d ((R)-(-)-3-Hydroxybutanoic acid-d) is the deuterium labeled (R)-3-Hydroxybutanoic acid (HY-W051723). (R)-3-Hydroxybutanoic acid is a metabolite, and converted from acetoacetic acid catalyzed by 3-hydroxybutyrate dehydrogenase. (R)-3-Hydroxybutanoic acid has applications as a nutrition source and as a precursor for vitamins, antibiotics and pheromones.

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