country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-N17653

Copy Link Print Information

13'-Carboxy-δ-tocopherol

13'-Carboxy-δ-tocopherol is a metabolite of long-chain vitamin E.13'-Carboxy-δ-tocopherol exhibits antiproliferative properties in cancer cells. 13'-Carboxy-δ-tocopherol activates caspase-3, caspase-9, causes PARP-1 cleavage, reduces mitochondrial membrane potential, increases ROS formation, and drives apoptosis.13'-Carboxy-δ-tocopherol can be used for the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

CAS No.: 1160974-35-5
Formula: C₂₇H₄₄O₄
Molecular Weight:432.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

13'-Carboxy-δ-tocopherol Chemical Structure

CAS No.: 1160974-35-5

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Caspase-3

Caspase-7

Caspase-9

PARP-1

All Caspase Isoforms :

All PARP Isoforms :

In Vitro

13'-Carboxy-δ-tocopherol (Compound δ-13′-COOH) (24 h) potently inhibits the growth of HepG2 cells with an EC₅₀ of 6.5 μM^[1].
13'-Carboxy-δ-tocopherol (20 μM; 6 h) induces significant apoptosis in HepG2 cells, inducing cleavage of caspase-3, caspase-7, caspase-9, and PARP-1^[1].
13'-Carboxy-δ-tocopherol (10 μM; 6 h) significantly increases intracellular ROS formation in HepG2 cells^[1].
13'-Carboxy-δ-tocopherol (10-20 μM; 1 h) reduces mitochondrial membrane potential in HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

human hepatoma HepG2 cells
Concentration:

20 μM
Incubation Time:

6 h
Result:

Induced pronounced cleavage of caspase-3, caspase-7, caspase-9, and PARP-1, indicating activation of the intrinsic apoptotic pathway.

Chemical Information

CAS No. 1160974-35-5
Molecular Weight 432.64
Formula C₂₇H₄₄O₄
SMILES

CC1=C2C(CC[C@](C)(O2)CCCC(C)CCCC(C)CCCC(C)C(O)=O)=CC(O)=C1
Structure Classification
- Phenols
- Ketones, Aldehydes, Acids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Birringer M, et al. Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress. Free Radic Biol Med. 2010;49(8):1315-1322. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

13'-Carboxy-δ-tocopherol

All Caspase Isoforms

All PARP Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

13'-Carboxy-δ-tocopherol Related Classifications

HY-N17653 Related Classifications