2. Apoptosis Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Epigenetics Cell Cycle/DNA Damage
  3. Apoptosis Mitochondrial Metabolism Reactive Oxygen Species (ROS) Caspase PARP Drug Metabolite
  4. 13'-Carboxy-δ-tocopherol

13'-Carboxy-δ-tocopherol is a metabolite of long-chain vitamin E.13'-Carboxy-δ-tocopherol exhibits antiproliferative properties in cancer cells. 13'-Carboxy-δ-tocopherol activates caspase-3, caspase-9, causes PARP-1 cleavage, reduces mitochondrial membrane potential, increases ROS formation, and drives apoptosis.13'-Carboxy-δ-tocopherol can be used for the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

13'-Carboxy-δ-tocopherol

13'-Carboxy-δ-tocopherol Chemical Structure

CAS No. : 1160974-35-5

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13'-Carboxy-δ-tocopherol Related Antibodies

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PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

13'-Carboxy-δ-tocopherol is a metabolite of long-chain vitamin E.13'-Carboxy-δ-tocopherol exhibits antiproliferative properties in cancer cells. 13'-Carboxy-δ-tocopherol activates caspase-3, caspase-9, causes PARP-1 cleavage, reduces mitochondrial membrane potential, increases ROS formation, and drives apoptosis.13'-Carboxy-δ-tocopherol can be used for the research of hepatocellular carcinoma[1].

IC50 & Target[1]

Caspase-3

 

Caspase-7

 

Caspase-9

 

PARP-1

 

In Vitro

13'-Carboxy-δ-tocopherol (Compound δ-13′-COOH) (24 h) potently inhibits the growth of HepG2 cells with an EC50 of 6.5 μM[1].
13'-Carboxy-δ-tocopherol (20 μM; 6 h) induces significant apoptosis in HepG2 cells, inducing cleavage of caspase-3, caspase-7, caspase-9, and PARP-1[1].
13'-Carboxy-δ-tocopherol (10 μM; 6 h) significantly increases intracellular ROS formation in HepG2 cells[1].
13'-Carboxy-δ-tocopherol (10-20 μM; 1 h) reduces mitochondrial membrane potential in HepG2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

13'-Carboxy-δ-tocopherol Related Antibodies

Western Blot Analysis[1]

Cell Line: human hepatoma HepG2 cells
Concentration: 20 μM
Incubation Time: 6 h
Result: Induced pronounced cleavage of caspase-3, caspase-7, caspase-9, and PARP-1, indicating activation of the intrinsic apoptotic pathway.
Molecular Weight

432.64

Formula

C27H44O4
CAS No.
SMILES

CC1=C2C(CC[C@](C)(O2)CCCC(C)CCCC(C)CCCC(C)C(O)=O)=CC(O)=C1
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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13'-Carboxy-δ-tocopherol Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13'-Carboxy-δ-tocopherol1160974-35-5ApoptosisMitochondrial MetabolismReactive Oxygen Species (ROS)CaspasePARPDrug Metabolitepoly ADP ribose polymerasehepatocellular carcinomaHepG2 cellsmitochondrial membrane potentialcaspase-3PARP-1caspase-7apoptosisreactive oxygen speciescaspase-9Inhibitorinhibitorinhibit

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