Transketolase

Transketolase is a key rate-limiting enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP). Transketolase is critical for energy transduction and for generating ribose for nucleic acid synthesis. Transketolase can convert ribulose 5-phosphate back into glucose 6-phosphate to generate more NADPH, and the reaction is thiamine-dependent. Transketolase has three isomer: TKT, TKTL1 and TKTL2. TKT is expressed in all investigated organisms, and is up-regulated in multiple cancer types^[1]^[2].

References:

[1]. Alexander-Kaufman K, et al. Transketolase: observations in alcohol-related brain damage research. Int J Biochem Cell Biol. 2009 Apr;41(4):717-20. [Content Brief]

[2]. Zhao J, et al. A review on research progress of transketolase. Neurosci Bull. 2009 Apr;25(2):94-9. [Content Brief]

Transketolase Inhibitors (6)

Transketolase Related Products (9):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-16339

N3PT	Inhibitor	99.56%
N3PT (N3-pyridyl thiamine) is a potent and selective transketolase inhibitor. N3PT is pyrophosphorylated and then binds to transketolase with an K_d value of 22 nM (Apo-TK, transketolase lacking bound thiamine).

HY-112889B

Oxythiamine diphosphate ammonium	Inhibitor
Oxythiamin diphosphate ammonium is a potent transketolase (TK) inhibitor.

HY-139731

Transketolase-IN-1	Inhibitor	99.06%
Transketolase-IN-1 is a promising herbicide candidate for weed control in wheat and maize fields targeting transketolase.

HY-151600

Transketolase-IN-2	Inhibitor	99.83%
Transketolase-IN-2 (compound 4w) is a potent Transketolase inhibitor. Transketolase-IN-2 shows strong inhibition of Digitaria sanguinalis and Amaranthus retroflexus (over 90% at 200 mg/L and about 80% at 100 mg/L). Transketolase-IN-2 can be used in studies of weed control.

HY-151604

Transketolase-IN-3	Inhibitor	98.52%
Transketolase-IN-3 is a potent transketolase (TK) inhibitor. Transketolase-IN-3 has herbicidal activity and has inhibitory effects against Digitaria sanguinalis (DS) and Amaranthus retroflexus (AR). Transketolase-IN-3 can be used for the research of herbicides.

HY-163311

Transketolase-IN-6
Transketolase-IN-6 (Compound 6bj) is a herbicide lead compound. Transketolase-IN-6 displays a highly inhibitory effect with the root inhibition of about 80% against Amaranthus retroflexus and Setaria viridis. Transketolase-IN-6 is a potent transketolase (TK) inhibitor.

HY-163310

Transketolase-IN-5	Inhibitor
Transketolase-IN-5 (compound 6ba) is a transketolase inhibitor. Transketolase-IN-5 shows herbicidal activity for Amaranthus retroflexus, Setariaviridis, Digitaria sanguinalis.

HY-112889

Oxythiamine diphosphate
Oxythiamin diphosphate is a potent transketolase (TK) inhibitor.

HY-E70075

α-Glycerophosphate Dehydrogenase-Triosephosphate
α-Glycerophosphate Dehydrogenase-Triosephosphate (GDH-TIM) is an enzyme mixture composed of glycerol phosphate dehydrogenase (GDH) and triphosphate isomerase (TIM). α-Glycerophosphate Dehydrogenase-Triosephosphate can be used to determine the activity of transketolase (TK) in hemolytic substances of red blood cells to evaluate vitamin B deficiency.

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