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Cat. No.: HY-N17652

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13′-Hydroxy-δ-tocopherol

13′-Hydroxy-δ-tocopherol is a metabolite of long-chain vitamin E. 13′-Hydroxy-δ-tocopherol can induces cells apoptosis and minor reduction in mitochondrial membrane potential. 13′-Hydroxy-δ-tocopherol can be used for the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

CAS No.: 1308347-24-1
Formula: C₂₇H₄₆O₃
Molecular Weight:418.65

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

13′-Hydroxy-δ-tocopherol Chemical Structure

CAS No.: 1308347-24-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

13′-Hydroxy-δ-tocopherol (Compound δ-13′-OH) (24 h) exhibits weak antiproliferative activity in HepG2 cells, with an EC₅₀ >50 μM^[1].
13′-Hydroxy-δ-tocopherol (20 μM; 6 h) induces significant apoptotic cell death in HepG2 cells, inducing cleavage of caspase-3, caspase-7, caspase-9, and PARP-1^[1].
13′-Hydroxy-δ-tocopherol (10 μM; 6 h) does not significantly induce intracellular or intramitochondrial ROS formation in HepG2 cells^[1].
13′-Hydroxy-δ-tocopherol (20 μM; 1 h) significantly reduces mitochondrial membrane potential by 20% in HepG2 cells when incubated at 20 μM for 1 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

human hepatoma HepG2 cells
Concentration:

20 μM
Incubation Time:

6 h
Result:

Induced less pronounced activation of caspase-3, caspase-7, and caspase-9, as well as PARP-1 cleavage, compared to long-chain carboxychromanol metabolites.

Chemical Information

CAS No. 1308347-24-1
Molecular Weight 418.65
Formula C₂₇H₄₆O₃
SMILES

CC1=C2C(CC[C@](C)(O2)CCCC(C)CCCC(C)CCCC(C)CO)=CC(O)=C1
Structure Classification
- Phenols
- Monophenols
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Birringer M, et al. Proapoptotic effects of long-chain vitamin E metabolites in HepG2 cells are mediated by oxidative stress. Free Radic Biol Med. 2010;49(8):1315-1322. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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