2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Mitochondrial Metabolism
  4. 13′-Hydroxy-δ-tocopherol

13′-Hydroxy-δ-tocopherol is a metabolite of long-chain vitamin E. 13′-Hydroxy-δ-tocopherol can induces cells apoptosis and minor reduction in mitochondrial membrane potential. 13′-Hydroxy-δ-tocopherol can be used for the research of hepatocellular carcinoma.

For research use only. We do not sell to patients.

13′-Hydroxy-δ-tocopherol

13′-Hydroxy-δ-tocopherol Chemical Structure

CAS No. : 1308347-24-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

13′-Hydroxy-δ-tocopherol Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

13′-Hydroxy-δ-tocopherol is a metabolite of long-chain vitamin E. 13′-Hydroxy-δ-tocopherol can induces cells apoptosis and minor reduction in mitochondrial membrane potential. 13′-Hydroxy-δ-tocopherol can be used for the research of hepatocellular carcinoma[1].

In Vitro

13′-Hydroxy-δ-tocopherol (Compound δ-13′-OH) (24 h) exhibits weak antiproliferative activity in HepG2 cells, with an EC50 >50 μM[1].
13′-Hydroxy-δ-tocopherol (20 μM; 6 h) induces significant apoptotic cell death in HepG2 cells, inducing cleavage of caspase-3, caspase-7, caspase-9, and PARP-1[1].
13′-Hydroxy-δ-tocopherol (10 μM; 6 h) does not significantly induce intracellular or intramitochondrial ROS formation in HepG2 cells[1].
13′-Hydroxy-δ-tocopherol (20 μM; 1 h) significantly reduces mitochondrial membrane potential by 20% in HepG2 cells when incubated at 20 μM for 1 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

13′-Hydroxy-δ-tocopherol Related Antibodies

Western Blot Analysis[1]

Cell Line: human hepatoma HepG2 cells
Concentration: 20 μM
Incubation Time: 6 h
Result: Induced less pronounced activation of caspase-3, caspase-7, and caspase-9, as well as PARP-1 cleavage, compared to long-chain carboxychromanol metabolites.
Molecular Weight

418.65

Formula

C27H46O3
CAS No.
SMILES

CC1=C2C(CC[C@](C)(O2)CCCC(C)CCCC(C)CCCC(C)CO)=CC(O)=C1
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

13′-Hydroxy-δ-tocopherol Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

13′-Hydroxy-δ-tocopherol1308347-24-1ApoptosisMitochondrial Metabolismintrinsic apoptotic pathwayhepatocellular carcinomaHepG2 cellsmitochondrial membrane potentialliver-derived cancer cellscaspase-3caspase-7apoptotic cell deathreactive oxygen speciescaspase-9Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
13′-Hydroxy-δ-tocopherol
Cat. No.:
HY-N17652
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.