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Results for "

nmda+receptor+antagonist

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (6) Apoptosis (2) Autophagy (1) Bacterial (4) Calcium Channel (2) Cytochrome P450 (1) Drug Isomer (1) Drug Metabolite (1) Endogenous Metabolite (2) Environmental Pollutants (1) Fungal (2) GABA Receptor (7) Glycine Receptor (GlyR) (1) iGluR (106) Influenza Virus (2) Isotope-Labeled Compounds (8) mGluR (2) Opioid Receptor (2) Potassium Channel (12) Reference Standards (12) Sigma Receptor (2) Sodium Channel (1) TNF Receptor (2)
By Research Areas:	Cancer (7) Cardiovascular Disease (4) Endocrinology (4) Infection (5) Inflammation/Immunology (8) Metabolic Disease (1) Neurological Disease (107)

By Targets:

Adrenergic Receptor (6)

Apoptosis (2)

Autophagy (1)

Bacterial (4)

Calcium Channel (2)

Cytochrome P450 (1)

Drug Isomer (1)

Drug Metabolite (1)

Endogenous Metabolite (2)

Environmental Pollutants (1)

Fungal (2)

GABA Receptor (7)

Glycine Receptor (GlyR) (1)

iGluR (106)

Influenza Virus (2)

Isotope-Labeled Compounds (8)

mGluR (2)

Opioid Receptor (2)

Potassium Channel (12)

Reference Standards (12)

Sigma Receptor (2)

Sodium Channel (1)

TNF Receptor (2)

By Research Areas:

Cancer (7)

Cardiovascular Disease (4)

Endocrinology (4)

Infection (5)

Inflammation/Immunology (8)

Metabolic Disease (1)

Neurological Disease (107)

114

Inhibitors & Agonists

Screening Libraries

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100714A

D-AP5 25+ Cited Publications D-APV; D-2-Amino-5-phosphonovaleric acid	iGluR	Neurological Disease
D-AP5 (D-APV) is a selective and competitive *NMDA receptor* antagonist with a K_d of 1.4 μM. D-AP5 (D-APV) inhibits the glutamate binding site of NMDA receptors .

HY-15084

Dizocilpine maleate Maximum Cited Publications 44 Publications Verification (+)-MK 801 Maleate	iGluR	Neurological Disease
Dizocilpine maleate (MK-801 maleate) is a potent, selective and non-competitive *NMDA* receptor antagonist with K_d of 37.2 nM in rat brain membranes.

HY-15084B

Dizocilpine Maximum Cited Publications 44 Publications Verification MK-801	iGluR	Neurological Disease
Dizocilpine (MK-801), a potent anticonvulsant, is a selective and non-competitive *NMDA receptor* antagonist, with a K_d of 37.2 nM in rat brain membranes. Dizocilpine acts by binding to a site located within the NMDA associated ion channel and thus prevents Ca ²⁺ flux .

HY-15066

CNQX 15+ Cited Publications FG9065	iGluR	Neurological Disease
CNQX (FG9065) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX is a competitive non-NMDA receptor antagonist . CNQX blocks the expression of fear-potentiated startle in rats .

HY-N0368

Linalool,98% (stabilized with MEHQ) 4 Publications Verification	Environmental Pollutants Apoptosis iGluR Endogenous Metabolite Bacterial TNF Receptor	Infection Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Linalool is a natural monoterpene which is a competitive *NMDA* receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-15066A

CNQX disodium 15+ Cited Publications FG9065 disodium	iGluR	Neurological Disease
CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist . CNQX disodium blocks the expression of fear-potentiated startle in rats .

HY-B1270

Isoxsuprine hydrochloride	Adrenergic Receptor iGluR	Neurological Disease Endocrinology
Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with K_is of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a *NMDA receptor* antagonist.

HY-B0369A

Orphenadrine citrate	iGluR	Neurological Disease Cancer
Orphenadrine citrate is an orally active and non-competitive *NMDA receptor* antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine citrate relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine citrate is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-13993

Ro 25-6981 5+ Cited Publications	iGluR	Neurological Disease
Ro 25-6981 is a potent, selective and activity-dependent NR2B subunit specific *NMDA receptor* antagonist. Ro 25-6981 shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 has the potential for the research of parkinson's disease (PD) .

HY-18698

L-701324	iGluR	Neurological Disease
L-701324 is a potent, orally active *NMDA receptor* antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC₅₀=2 nM). L-701324 has antidepressant activity .

HY-15084A

(-)-Dizocilpine maleate (-)-MK-801 maleate	iGluR	Neurological Disease
(-)-Dizocilpine maleate ((-)-MK-801 maleate) is a less active (-)-enantiomer of Dizocilpine. (-)-Dizocilpine maleate is a selective and non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist with a K_i of 211.7 nM. (-)-Dizocilpine maleate has antidepressant effects .

HY-13993A

Ro 25-6981 Maleate 5+ Cited Publications	iGluR	Neurological Disease
Ro 25-6981 Maleate is a potent, selective and activity-dependent NR2B subunit specific *NMDA receptor* antagonist. Ro 25-6981 Maleat shows anticonvulsant and anti-parkinsonian activity. Ro 25-6981 Maleate has the potential for the research of parkinson's disease (PD) .

HY-100814

(R)-CPP 1 Publications Verification	iGluR	Neurological Disease
(R)-CPP is a highly potent *NMDA* receptor antagonist .

HY-101178

L-689560	iGluR	Neurological Disease
L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases .

HY-110097

Aptiganel hydrochloride CNS 1102	iGluR	Neurological Disease
Aptiganel hydrochloride (Cerestat) is a non-competitive *NMDA receptor* antagonist with neuroprotective effect.

HY-16502

Crocetin disodium 3 Publications Verification Transcrocetin disodium; trans-Crocetin disodium	iGluR	Cancer
Crocetin (Transcrocetin) disodium, extracted from saffron (Crocus sativus L.), acts as an *NMDA receptor* antagonist with high affinity.

HY-13059

SDZ 220-581	iGluR	Neurological Disease
SDZ 220-581 is an orally active, potent, competitive *NMDA receptor* antagonist with pK_i value of 7.7 .

HY-12881

Eliprodil SL-820715	iGluR	Neurological Disease
Eliprodil(SL-820715) is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).

HY-107711

DQP-1105 1 Publications Verification	iGluR	Neurological Disease
DQP-1105 is a potent noncompetitive *NMDA receptor* antagonist. DQP-1105 inhibits GluN2C- and GluN2D-containing receptors (IC₅₀=7.0 and 2.7 μM, respectively). The IC₅₀ values are at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, GluA1-, or GluK2-containing receptors .

HY-107706

Co 101244 hydrochloride PD 174494 hydrochloride	iGluR	Neurological Disease
Co 101244 (PD 174494) hydrochloride is a NR2B-containing *NMDA receptor* antagonist .

HY-150138

Gavestinel GV 150526	iGluR	Neurological Disease
Gavestinel (GV 150526) is a selective and potent the glycine site of the *NMDA receptor* antagonist. Gavestinel has neuroprotectant effects .

HY-B0365AS

Memantine-d6 hydrochloride	Cytochrome P450 iGluR Autophagy	Neurological Disease
Memantine-d₆ (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with K_is of 0.51 nM and 94.9 μM, respectively .

HY-42937

Crocetin meglumine 3 Publications Verification Transcrocetin meglumine; trans-Crocetin meglumine	iGluR	Cancer
Crocetin (Transcrocetin) meglumine, extracted from saffron (Crocus sativus L.), acts as an *NMDA receptor* antagonist with high affinity.

HY-107713

PPDA	iGluR	Neurological Disease
PPDA is a subtype-selective *NMDA* receptor antagonist that preferentially binds to NR2C/NR2D containing receptors .

HY-19168

Perzinfotel EAA-090	iGluR	Neurological Disease
Perzinfotel (EAA-090) is a potent, selective, and competitive *NMDA receptor* antagonist with neuroprotective effects. Perzinfotel (EAA-090) shows high affinity (IC₅₀=30 nM) for the glutamate site .

HY-160604

Remacemide FPL 12924; PR 934-423; FPL 13592	iGluR	Neurological Disease
Remacemide (FPL 12924) is an orally active, non-competitive, low-affinity *NMDA receptor* antagonist. Remacemide shows neuroprotection activity in animal models of hypoxia and ischemic stroke. Remacemide is also an anticonvulsant, and can be used in Parkinson's disease and Huntington's disease research .

HY-B1283

Mephenesin	iGluR	Neurological Disease
Mephenesin is an *NMDA receptor* antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm .

HY-B1126

Orphenadrine hydrochloride	iGluR	Neurological Disease Cancer
Orphenadrine hydrochloride is an orally active and non-competitive *NMDA receptor* antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-152052S

Linalool-d5	Isotope-Labeled Compounds	Others
Linalool-d₅ is the deuterium labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive *NMDA* receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-110152

LSN2463359	mGluR	Neurological Disease
LSN2463359 is positive allosteric modulator of metabotropic glutamate 5 (mGlu₅). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model . LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-15436

L-687414	iGluR	Neurological Disease
L-687414 is an orally active glycine-site *NMDA* receptor antagonist or low-potency partial agonist. L-687414 has anticonvulsant activity .

HY-N12180A

Hodgkinsine	Opioid Receptor Bacterial Fungal	Infection Neurological Disease
Hodgkinsine is an opioid receptor agonist and *NMDA* receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities .

HY-W835175

Neramexane hydrochloride	iGluR	Neurological Disease
Neramexane hydrochloride is an oral N-methyl-D-aspartate (NMDA) receptor antagonist, as a potential neuroprotectant for various central nervous system disorders, including Alzheimer's disease, and for the potential study of drug and alcohol dependence, and pain.

HY-106969A

ZD 9379 sodium	Glycine Receptor (GlyR) iGluR	Cardiovascular Disease Neurological Disease
ZD 9379 sodium is a competitive glycine/NMDA receptor antagonist, with an IC₅₀ value of 75 nM (glutamate site). ZD 9379 sodium selectively antagonizes the glycine binding site (GlyB site) on the NMDA receptor, inhibiting the binding of glycine to the NMDA receptor and alleviating excitotoxicity. ZD 9379 sodium reduces the frequency of cortical spreading depression (SDs), alleviates energy depletion in the ischemic penumbra, and delays the expansion of infarction. ZD 9379 sodium reduces the infarct volume and improves neurological function in mouse models. ZD 9379 sodium can be used in studies of acute ischemic stroke, etc .

HY-146101

NMDA receptor antagonist 5	iGluR	Neurological Disease
NMDA receptor antagonist 5 (Compound 10e) is a potent, brain permeable and non-toxic *NMDA receptor* antagonist. NMDA receptor antagonist 5 can be used for neurological disorder research .

HY-155185A

NMDA receptor antagonist 8	iGluR	Neurological Disease
NMDA receptor antagonist 8 (Compound (R)-10a) is GluN2B subunit-selective *NMDA Receptor* antagonist, with an K_i of 265 nM and an IC₅₀ of 62 nM. NMDA receptor antagonist 8 can be used for research of neurodegenerative diseases .

HY-155185

NMDA receptor antagonist 7	iGluR	Neurological Disease
NMDA receptor antagonist 7 (Compound (S)-10a) is GluN2B subunit-selective *NMDA Receptor* antagonist, with an K_i of 93 nM and an IC₅₀ of 72 nM. NMDA receptor antagonist 7 can be used for research of neurodegenerative diseases .

HY-139708

NMDA receptor antagonist-3	iGluR	Neurological Disease
NMDA receptor antagonist-3, a *NMDA* receptor antagonist, stands out with a remarkable percentage of recovery (40.0%, at 100 μM) and safe toxicological profile in SH-SY5Y and human adipose mesenchymal stem cells.

HY-136459

NMDA receptor antagonist 2	iGluR	Neurological Disease
NMDA receptor antagonist 2 is a potent and orally active NR2B subtype-selective NMDA antagonist with an IC₅₀ and a K_i of 1.0 nM and 0.88 nM, respectively. NMDA receptor antagonist 2 is used for the study of neuropathic pain and Parkinson’s disease .

HY-155049

NMDA receptor antagonist 6	iGluR	Neurological Disease
NMDA receptor antagonist 6 (compound 13b) is an antagonist of **NMDA receptor*, targeting to the glycine binding site. NMDA receptor antagonist* 6 shows cytoneuroprotective potency, and protects PC12 cells against NMDA-induced injury and cell apoptosis .

HY-146588

NMDA receptor antagonist 4	iGluR	Neurological Disease
NMDA receptor antagonist 4 (IIc) is a uncompetitive, voltage-dependent, orally active NMDAR blocker, with an IC₅₀ of 1.93 μM. NMDA receptor antagonist 4 shows a positive predicted blood-brain-barrier (BBB) permeability, and can be studied in Alzheimer's disease .

HY-138940

3-Methoxy PCE hydrochloride 3-MEO PCE hydrochloride	iGluR	Neurological Disease
3-Methoxy PCE (3-MEO PCE) hydrochloride is structurally classified as an arylcyclohexylamine and is an /b>NMDA receptor antagonist with a pK_i value of 7.22 .

HY-107702

CGP 37849	iGluR	Neurological Disease
CGP 37849 is a potent, competitive and orally active N-methyl-D-aspartate (NMDA) receptor antagonist. CGP 37849 is an anticonvulsant in rodents and has antidepressant and anxiolytic-like effects .

HY-105450

GPI-3000	iGluR	Neurological Disease
GPI-3000 is a *NMDA receptor* antagonist. GPI-3000 can ameliorate metabolic injury and shows neuroprotective effect. GPI-3000 can be used for the researches of metabolic and neurological disease .

HY-B1585B

Caramiphen (edisylate) Parpanil (edisylate)	iGluR	Neurological Disease
Caramiphen edisylate (Parpanil edisylate) is an anticholinergic agent with *NMDA* receptor antagonist activity. Caramiphen edisylate can be used to inhibit diseases related to cholinergic neurotransmission. Caramiphen edisylate exerts its pharmacological effects by blocking cholinergic effects .

HY-107695

Remacemide hydrochloride FPL 12924AA	iGluR Sodium Channel	Neurological Disease
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na ⁺ channel, is a weak uncompetitive *NMDA receptor* antagonist with IC₅₀s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively . Remacemide hydrochloride is an anticonvulsant agent .

HY-126123

*NR2B-selective NMDA receptor antagonist* 1**	iGluR Potassium Channel	Neurological Disease
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC₅₀s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier .

HY-108920

4-Chlorokynurenine 4-Cl-KYN; AV-101	iGluR	Neurological Disease
4-Chlorokynurenine (4-Cl-KYN) is a prodrug of 7-Chlorokynurenic acid (NMDA* receptor antagonist*) (HY-100811). 4-Chlorokynurenine has orally activity and blood-brain permeability. 4-Chlorokynurenine can reduce depressive symptoms and neurotoxicity. 4-Chlorokynurenine can be used for the research of neurological disease, such as depression and seizure .

HY-N0368S1

Linalool-13C3	Apoptosis Endogenous Metabolite iGluR Bacterial Isotope-Labeled Compounds	Cancer
Linalool- ¹³C₃ is ¹³C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-183200

NMDA receptor antagonist 10	iGluR	Neurological Disease
NMDA receptor antagonist 10 is a *NMDA receptor* antagonist with an IC₅₀ of 28 μM. NMDA receptor antagonist 10 inhibits glycine action at the NMDA receptor glycine site. NMDA receptor antagonist 10 can be used for research on neurological diseases .

Cat. No.	Product Name

HY-L070

Neuroprotective Compound Library

1,748 compounds

Neurodegenerative diseases are characterised by progressive dysfunction and death of neurons, such as Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis (MS). Neuroprotection is an approach to preserve neurons so that neurons cannot be hurt by different pathological factors in neurodegenerative diseases. Neuroprotectors are some agonists and antagonists targeting some key targets in neuroprotactive signal pathways, such as calcium and sodium channel blockers, GABA receptor agonists, NMDA receptor Antagonists, etc. Current neuroprotectors cannot reverse existing damage, but they may protect against further nerve damage and slow down any degeneration of the central nervous system (CNS) and still play important roles in the treatment of neurodegenerative diseases.

MCE offers a unique collection of 1,748 compounds with potential neuroprotective activities. These compounds mainly act on some key targets in neuroprotetive signal pathways, such as calcium channel, sodium channel, adenosine A1 receptor, etc. MCE Neuroprotective Compopund Library is a useful tool in neuroprotective drug discovery.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0368

Linalool,98% (stabilized with MEHQ) 4 Publications Verification	Cardiovascular Disease Structural Classification Other Monoterpenes Classification of Application Fields Terpenoids Amberboa moschata (L.) DC. Umbelliferae Plants Endogenous metabolite Disease Research Fields Source Classification	Environmental Pollutants Apoptosis iGluR Endogenous Metabolite Bacterial TNF Receptor
Linalool is a natural monoterpene which is a competitive *NMDA* receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-12882A

Ifenprodil tartrate Maximum Cited Publications 10 Publications Verification NP-120 tartrate; RC-61-91 tartrate	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Crassulaceae Sedum sarmentosum Bunge Plants Disease Research Fields Source Classification	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive *NMDA* receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-16502

Crocetin disodium 3 Publications Verification Transcrocetin disodium; trans-Crocetin disodium	Classification of Application Fields Terpenoids Diterpenoids Lridaceae Plants Crocus sativus L. Disease Research Fields Cancer Source Classification	iGluR
Crocetin (Transcrocetin) disodium, extracted from saffron (Crocus sativus L.), acts as an *NMDA receptor* antagonist with high affinity.

HY-42937

Crocetin meglumine 3 Publications Verification Transcrocetin meglumine; trans-Crocetin meglumine	Classification of Application Fields Terpenoids Diterpenoids Lridaceae Plants Crocus sativus L. Disease Research Fields Source Classification Cancer	iGluR
Crocetin (Transcrocetin) meglumine, extracted from saffron (Crocus sativus L.), acts as an *NMDA receptor* antagonist with high affinity.

HY-N12180A

Hodgkinsine	Alkaloids Arecaceae Bercht. & J. Presl Rubiaceae Arecaceae Plants Indole Alkaloids Source Classification	Opioid Receptor Bacterial Fungal
Hodgkinsine is an opioid receptor agonist and *NMDA* receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine has antiviral, antibacterial and antifungal activities .

HY-N12180

Hodgkinsine B	Alkaloids Arecaceae Bercht. & J. Presl Rubiaceae Arecaceae Plants Indole Alkaloids Source Classification	Opioid Receptor Bacterial Fungal
Hodgkinsine B is an opioid receptor agonist and *NMDA* receptor antagonist, which has analgesic and anti-injurial effects. In addition, Hodgkinsine B has antiviral, antibacterial and antifungal activities .

HY-N5159

Ampullosporin A	Structural Classification Microorganisms Antibiotics Other Antibiotics Source Classification	iGluR
Ampullosporin A is a peptaibol-type polypeptide that can be isolated from the fungus Sepedonium ampullosporum HKI-0053, exhibiting neuroleptic-like activity. Ampullosporin A can inhibit hyperactivity induced by NMDA receptor antagonist MK-801 (HY-15084B) and ameliorate social behavior abnormalities caused by subchronic drug treatment. Ampullosporin A alters the activity of glutamate receptors without affecting dopamine D1 and D2 receptors .

HY-N7513R

Homovanillyl alcohol (Standard)	Structural Classification Monophenols other families Phenols Plants Source Classification	TNF Receptor Reference Standards Drug Metabolite
Orphenadrine (hydrochloride) (Standard) is the analytical standard of Orphenadrine (hydrochloride). This product is intended for research and analytical applications. Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a Ki of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-12882AR

Ifenprodil tartrate (Standard) NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)	Alkaloids Piperidine Alkaloids Crassulaceae Sedum sarmentosum Bunge Plants Source Classification	iGluR Potassium Channel Reference Standards
Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .

Cat. No.	Product Name	Chemical Structure

HY-B0365AS

Memantine-d6 hydrochloride
Memantine-d₆ (hydrochloride) is the deuterium labeled Memantine hydrochloride. Memantine (hydrochloride) (D-145 (hydrochloride)) is a moderate affinity, uncompetitive NMDA receptor antagonist, inhibit CYP2B6 and CYP2D6 with K_is of 0.51 nM and 94.9 μM, respectively .

HY-152052S

Linalool-d5

Linalool-d₅ is the deuterium labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-N0368S1

Linalool-13C3

Linalool- ¹³C₃ is ¹³C labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-B0369AS

Orphenadrine-d3 citrate
Orphenadrine-d₃ (citrate) is the deuterium labeled Orphenadrine citrate. Orphenadrine citrate is a NMDA receptor antagonist with Ki of 6.0 +/- 0.7 μM, HERG potassium channel blocker.

HY-B1270S

Isoxsuprine-d6 hydrochloride
Isoxsuprine-d₆ (hydrochloride) is the deuterium labeled Isoxsuprine hydrochloride. Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

HY-B1283S

Mephenesin-d3
Mephenesin-d₃ is deuterium labeled Mephenesin. Mephenesin is an *NMDA receptor* antagonist. Mephenesin is also a central muscle relaxant with antianxiety, muscle-paralyzing and anticonvulsant effects. Mephenesin acts directly on the skeletal muscle fibres to produce skeletal muscle relaxation. Mephenesin is promising for research of spasticity or painful muscle spasm .

HY-B1126S

Orphenadrine-d3 hydrochloride

Orphenadrine-d₃ (hydrochloride) is the deuterium labeled Orphenadrine hydrochloride . Orphenadrine hydrochloride is an orally active and non-competitive NMDA receptor antagonist (crosses the blood-brain barrier) with a K_i of 6.0 μM. Orphenadrine hydrochloride relieves stiffness, pain and discomfort due to muscle strains, sprains or other injuries. Orphenadrine hydrochloride is also used to relieve tremors associated with parkinson's disease. Orphenadrine citrate has good neuroprotective properties, can be used in studies of neurodegenerative diseases .

HY-W010410S

Oct-1-en-3-ol-d3

Oct-1-en-3-ol-d₃ is deuterated labeled Linalool (HY-N0368). Linalool is a natural monoterpene which is a competitive NMDA receptor antagonist. Linalool is orally active and crosses the blood-brain barrier. Linalool has anticancer, antibacterial, anti-inflammatory, neuroprotective, anxiolytic, antidepressant, anti-stress, cardioprotective, hepatoprotective, nephroprotective and pulmonary protective activities .

HY-W709349S

Flupirtine-d6 hydrochloride

Flupirtine-d₆ (D 9998-d₆) hydrochloride is the deuterium labeled Flupirtine hydrochloride (HY-W709349). Flupirtine hydrochloride is an orally active, blood-brain barrier-crossing non-opioid analgesic and neuroprotective agent. Flupirtine hydrochloride is a neuronal potassium channel opener (Kv7 activator), a NMDA receptor antagonist and a GABA receptor activator. Flupirtine hydrochloride stabilizes blood-brain-barrier integrity, reduces oxidative stress and brain leukocyte infiltration, enhances angioneurogenesis, suppresses calcium influx, stabilizes neuronal resting membrane potential, and counteracts focal cerebral ischemia. Flupirtine hydrochloride exhibits analgesic, muscle relaxant properties, protects neurons from excitotoxic, ischemic, or cytokine-mediated death. Flupirtine hydrochloride functions as a non-opioid analgesic without antipyretic or antiphlogistic properties, shows no relevant affinity to opiate receptor. Flupirtine hydrochloride can be used for the research of focal cerebral ischemia, pain, Alzheimer’s disease, or multiple sclerosis .

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