1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. L-689560

L-689560 

Cat. No.: HY-101178
Handling Instructions

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases.

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L-689560 Chemical Structure

L-689560 Chemical Structure

CAS No. : 139051-78-8

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Description

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases[1][2].

In Vitro

L-689560 is a 2-carboxytetrahydroquinoline antagonist[2].

In Vivo

L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model[1]

Animal Model: Adult male Sprague-Dawley (SD) rats middle cerebral artery occlusion (MCAO) model[1]
Dosage: 1 mg/kg
Administration: IP
Result: Significantly reduced the neuroprotective effect of glycine after glycine receptors.
Molecular Weight

380.23

Formula

C₁₇H₁₅Cl₂N₃O₃

CAS No.

139051-78-8

SMILES

O=C([[email protected]@H]1NC2=C(C(Cl)=CC(Cl)=C2)[[email protected]@H](NC(NC3=CC=CC=C3)=O)C1)O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

L-689560L689560L 689560iGluRIonotropic glutamate receptorsN-methyl-D-aspartateNMDAGluN1glycineradiolabeledligandneurological2-carboxytetrahydroquinolineInhibitorinhibitorinhibit

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L-689560
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HY-101178
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