L-689560 

L-689560 is a potent N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. L-689560 is widely used as a radiolabeled ligand in binding studies and used for study the roles of NMDA receptors in normal neurological processes as well as in diseases^[1][2].

L-689560 is a 2-carboxytetrahydroquinoline antagonist^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

L-689560 (1 mg/kg, ip) significantly reduces the neuroprotective effect of glycine after glycine receptors and the channel activity of NMDA receptors (NMDARs) are suppressed. L-689560 blocks glycine-induced increase of Akt phosphorylation in the MCAO model^[1]

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

380.23

C₁₇H₁₅Cl₂N₃O₃

139051-78-8

Solid

White to off-white

O=C([C@@H]1NC2=C(C(Cl)=CC(Cl)=C2)[C@@H](NC(NC3=CC=CC=C3)=O)C1)O

Room temperature in continental US; may vary elsewhere.

• [1]. Juan Chen, et al. A non-ionotropic activity of NMDA receptors contributes to glycine-induced neuroprotection in cerebral ischemia-reperfusion injury. 15 June 2017

  [2]. Kvist T, et al. Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem. 2013 Nov 15;288(46):33124-35.  [Content Brief]