2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR Sodium Channel
  4. Remacemide hydrochloride

Remacemide hydrochloride  (Synonyms: FPL 12924AA)

Cat. No.: HY-107695
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Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.

For research use only. We do not sell to patients.

Remacemide hydrochloride Chemical Structure

Remacemide hydrochloride Chemical Structure

CAS No. : 111686-79-4

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Remacemide hydrochloride Related Antibodies

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Description

Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2].

IC50 & Target

IC50: 68-76 μM (NMDA receptor)[1]
IC50:160.6 μM(sodium channel)[2]
In Vitro

Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Remacemide hydrochloride Related Antibodies
In Vivo

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague–Dawley rats ( 190-210 g )[3]
Dosage: 100 mg/kg and 150 mg/kg
Administration: Orogastric gavage; once a day; 7 days
Result: Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
Molecular Weight

304.81

Formula

C17H21ClN2O
CAS No.
SMILES

NCC(NC(C)(C1=CC=CC=C1)CC2=CC=CC=C2)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Remacemide hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Remacemide111686-79-4FPL 12924AAiGluRSodium ChannelIonotropic glutamate receptorsNa channelsNa+ channelsanticonvulsantNMDAsodiumchannelInhibitorinhibitorinhibit

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