Remacemide hydrochloride
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.
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- CAS No.: 111686-79-4
- 화학식: C17H21ClN2O
- 분자량:304.81
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
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Biological Activity
제품 설명
IC50 & Target
IC50: 68-76 μM (NMDA receptor)[1]
IC50:160.6 μM(sodium channel)[2]
In Vitro
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Sprague–Dawley rats ( 190-210 g )[3]
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Dosage:100 mg/kg and 150 mg/kg
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Administration:Orogastric gavage; once a day; 7 days
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Result:Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
Chemical Information
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CAS No. 111686-79-4
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분자량 304.81
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화학식 C17H21ClN2O
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SMILES
NCC(NC(C)(C1=CC=CC=C1)CC2=CC=CC=C2)=O.[H]Cl
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Synonyms
FPL 12924AA
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
[1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [Content Brief]
[2]. Sarah Santangeli, et al. Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [Content Brief]
[3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Remacemide hydrochloride Related Classifications
HY-107695 Related Classifications
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