1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
    Sodium Channel
  3. Remacemide hydrochloride

Remacemide hydrochloride (Synonyms: FPL 12924AA)

Cat. No.: HY-107695
Handling Instructions

Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.

For research use only. We do not sell to patients.

Remacemide hydrochloride Chemical Structure

Remacemide hydrochloride Chemical Structure

CAS No. : 111686-79-4

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Description

Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2].

IC50 & Target

IC50: 68-76 μM (NMDA receptor)[1]
IC50:160.6 μM(sodium channel)[2]

In Vitro

Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague–Dawley rats ( 190-210 g )[3]
Dosage: 100 mg/kg and 150 mg/kg
Administration: Orogastric gavage; once a day; 7 days
Result: Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
Molecular Weight

304.81

Formula

C₁₇H₂₁ClN₂O

CAS No.
Shipping

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Product Name:
Remacemide hydrochloride
Cat. No.:
HY-107695
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