Remacemide hydrochloride
Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively. Remacemide hydrochloride is an anticonvulsant agent.
For research use only. We do not sell to patients.
- CAS No.: 111686-79-4
- Formula: C17H21ClN2O
- Molecular Weight:304.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 68-76 μM (NMDA receptor)[1]
IC50:160.6 μM(sodium channel)[2]
Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female Sprague–Dawley rats ( 190-210 g )[3]
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Dosage:100 mg/kg and 150 mg/kg
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Administration:Orogastric gavage; once a day; 7 days
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Result:Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
Chemical Information
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CAS No. 111686-79-4
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Molecular Weight 304.81
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Formula C17H21ClN2O
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SMILES
NCC(NC(C)(C1=CC=CC=C1)CC2=CC=CC=C2)=O.[H]Cl
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Synonyms
FPL 12924AA
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. G C Palmer, et al. Neuroprotective properties of the uncompetitive NMDA receptor antagonist remacemide hydrochloride. Ann N Y Acad Sci. 1995 Sep 15;765:236-47; discussion 248. [Content Brief]
[2]. Sarah Santangeli, et al. Na+ channel effects of remacemide and desglycinyl-remacemide in rat cortical synaptosomes. Eur J Pharmacol. 2002 Mar 1;438(1-2):63-8. [Content Brief]
[3]. L K M Wright, et al. Behavioral effects associated with chronic ketamine or remacemide exposure in rats. Neurotoxicol Teratol. May-Jun 2007;29(3):348-59. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Remacemide hydrochloride Related Classifications
HY-107695 Related Classifications
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