Ro 04-5595 hydrochloride
Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM).
For research use only. We do not sell to patients.
- CAS No.: 64047-73-0
- Formula: C19H23Cl2NO2
- Molecular Weight:368.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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GluN2B 31 nM (Ki) |
Ro 04-5595 hydrochloride (10 mg/kg, i.p., for 6 days) reduced AMPA to NMDA ratio in Cocaine self-administering rats[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Methamphetamine (MA) treated mice[1]
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Dosage:3-30 mg/kg
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Administration:i.p., given 30 min before injection of MA (2 mg/kg, i.p.)
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Result:Dose-dependently decreased MA-induced locomotor activity.
Chemical Information
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CAS No. 64047-73-0
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Molecular Weight 368.30
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Formula C19H23Cl2NO2
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SMILES
ClC(C=C1)=CC=C1CCC2C3=CC(O)=C(OC)C=C3CCN2C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mutel V, et al. In vitro binding properties in rat brain of [3H]Ro 25-6981, a potent and selective antagonist of NMDA receptors containing NR2B subunits. J Neurochem. 1998 May;70(5):2147-55. [Content Brief]
[2]. Li MH, et al. Amphetamine and Methamphetamine Increase NMDAR-GluN2B Synaptic Currents in Midbrain Dopamine Neurons. Neuropsychopharmacology. 2017 Jun;42(7):1539-1547. [Content Brief]
[3]. deBacker J, et al. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40(2):394-405. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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