2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR
  4. Ro 04-5595 hydrochloride

Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM).

For research use only. We do not sell to patients.

Ro 04-5595 hydrochloride Chemical Structure

Ro 04-5595 hydrochloride Chemical Structure

CAS No. : 64047-73-0

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Ro 04-5595 hydrochloride Related Antibodies

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Description

Ro 04-5595 hydrochloride is a GluN2B-selective NMDA receptor antagonist (Ki: 31 nM)[1].

IC50 & Target[1]

GluN2B

31 nM (Ki)

In Vivo

Ro 04-5595 hydrochloride (5-20 mg/kg, i.p.) inhibits MA-induced locomotor stimulation in mice[2].
Ro 04-5595 hydrochloride (10 mg/kg, i.p., for 6 days) reduced AMPA to NMDA ratio in Cocaine self-administering rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Methamphetamine (MA) treated mice[1]
Dosage: 3-30 mg/kg
Administration: i.p., given 30 min before injection of MA (2 mg/kg, i.p.)
Result: Dose-dependently decreased MA-induced locomotor activity.
Molecular Weight

368.30

Formula

C19H23Cl2NO2
CAS No.
SMILES

ClC(C=C1)=CC=C1CCC2C3=CC(O)=C(OC)C=C3CCN2C.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ro 04-5595 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ro 04-559564047-73-0iGluRIonotropic glutamate receptorsGluN2BMethamphetamineAMPAlocomotorInhibitorinhibitorinhibit

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Ro 04-5595 hydrochloride
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HY-107696
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