1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. Selfotel

Selfotel (Synonyms: CGS 19755)

Cat. No.: HY-15086
Handling Instructions

Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA)-preferring receptor. CGS 19755 inhibits the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type receptors with an IC50 of 50 nM.

For research use only. We do not sell to patients.

Selfotel Chemical Structure

Selfotel Chemical Structure

CAS No. : 110347-85-8

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Description

Selfotel (CGS 19755) is a selective and competitive antagonist at N-methyl-D-aspartate (NMDA)-preferring receptor. CGS 19755 inhibits the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type receptors with an IC50 of 50 nM[1][2].

IC50 & Target

IC50: 50 nM (the binding of [3H]-3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to NMDA-type receptors)[2].

In Vitro

Selfotel (CGS 19755) results in a concentration-dependent reduction in neuronal death as assessed by phase-contrast microscopy and by measurement of LDH release into the bathing medium 20-24 h later. The mean (±SD) ED50 for CGS 19755 against NMDA toxicity is 25.4 ± 30.8 μM, determined from 6 experiments, each using 4 cultures per condition[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Selfotel (CGS 19755) administered p.o. by gavage has little or no effect in these test procedures. In an experimental model of anxiety in rats[1].
Selfotel (CGS 19755) significantly increases conflict responding within a relatively narrow dose range (minimum effective dose, 1.73 mg/kg i.p.)[1].
Selfotel (CGS 19755) blocks the harmaline-induced increase in cerebellar cyclic GMP levels at a dose of 4 mg/kg i.p. with duration of action exceeding 2 hr[2].
Selfotel (CGS 19755) inhibits convulsions elicited by maximal electroshock in rat (ED50 = 3.8 mg/kg i.p. 1 hr after administration) and in mouse (ED50 = 2.0 mg/kg i.p. 0.5 hr after administration)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

223.16

Formula

C₇H₁₄NO₅P

CAS No.

110347-85-8

SMILES

O=C([[email protected]@H]1NCC[[email protected]](CP(O)(O)=O)C1)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SelfotelCGS 19755CGS19755CGS-19755iGluRIonotropic glutamate receptorsInhibitorinhibitorinhibit

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