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Cat. No.: HY-183200

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NMDA receptor antagonist 10

NMDA receptor antagonist 10 is a NMDA receptor antagonist with an IC₅₀ of 28 μM. NMDA receptor antagonist 10 inhibits glycine action at the NMDA receptor glycine site. NMDA receptor antagonist 10 can be used for research on neurological diseases.

For research use only. We do not sell to patients.

CAS No.: 909259-28-5
Formula: C₆H₁₂N₂O₃
Molecular Weight:160.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NMDA receptor antagonist 10 Chemical Structure

CAS No.: 909259-28-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

NMDA Receptor

28 μM (IC₅₀)

All iGluR Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Oocyte	IC₅₀	28 μM Compound: 2	Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological response Activity at rat NR1/NR2A receptor expressed in Xenopus oocytes assessed as inhibition of glycine-induced electrophysiological response	[PMID: 19394821]

In Vitro

NMDA receptor antagonist 10 (Compound 2) exhibits an IC₅₀ of 28 μM against NMDA receptor glycine site^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 909259-28-5
Molecular Weight 160.17
Formula C₆H₁₂N₂O₃
SMILES

OC(CNC(C[C@@H](N)C)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Nguyen KT, et al. 3-(aminomethyl)piperazine-2,5-dione as a novel NMDA glycine site inhibitor from the chemical universe database GDB. Bioorg Med Chem Lett. 2009;19(14):3832-3835. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NMDA receptor antagonist 10

All iGluR Isoforms