NR2B-selective NMDA receptor antagonist 1
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier.
For research use only. We do not sell to patients.
- CAS No.: 457897-92-6
- Formula: C18H22Cl2N2O4S
- Molecular Weight:433.35
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
0.73 μM
Compound: 29
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Displacement of [3H]astemizole from human ERG expressed in HEK293 cells
Displacement of [3H]astemizole from human ERG expressed in HEK293 cells
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[PMID: 18800760] |
| Oocyte | IC50 |
0.05 μM
Compound: 29
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Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method
Inhibition of rat recombinant NR1/NR2B receptor expressed in Xenopus oocytes assessed as inhibition of glutamate and glycine-induced evoked current by two electrode voltage clamp method
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[PMID: 18800760] |
In Vitro
NR2B-selective NMDA receptor antagonist 1 (compound 29) (1 μM) can attenuates LDH level induced by NMDA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 457897-92-6
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Molecular Weight 433.35
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Formula C18H22Cl2N2O4S
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SMILES
CS(NC1=CC=C(C=C1)OC[C@@H](O)CNCCC2=CC(Cl)=C(C=C2)Cl)(=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NR2B-selective NMDA receptor antagonist 1 Related Classifications
HY-126123 Related Classifications
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