457897-92-6
457897-92-6
Chemical Structure
NR2B-selective NMDA receptor antagonist 1
- CAS. Nr.: 457897-92-6
- Formula:C18H22Cl2N2O4S
- Molecular Weight:433.35
IUPAC Name: (S)-N-(4-(3-((3,4-dichlorophenethyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide
InChIKey: GEFDXUZHLNJUMR-HNNXBMFYSA-N
SMILES: CS(NC1=CC=C(C=C1)OC[C@@H](O)CNCCC2=CC(Cl)=C(C=C2)Cl)(=O)=O
Biological Activity: NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier[1].
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NR2B-selective NMDA receptor antagonist 1 | NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC50s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier. | |||||||||||||||||||||
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References
