1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. CGP 39551

CGP 39551 

Cat. No.: HY-107703
Handling Instructions

CGP 39551 is a potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potent anticonvulsant activity. CGP 39551 shows measurable inhibitory activity at both L-[3H]-glutamate (Ki=8.4 μM).

For research use only. We do not sell to patients.

CGP 39551 Chemical Structure

CGP 39551 Chemical Structure

CAS No. : 127910-32-1

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Description

CGP 39551 is a potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potent anticonvulsant activity[1]. CGP 39551 shows measurable inhibitory activity at both L-[3H]-glutamate (Ki=8.4 μM)[2].

In Vitro

CGP 39551 inhibits the binding of the selective NMDA receptor antagonist, [3H]-CPP to rat brain postsynaptic densities (PSDs) with a Ki of 310 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CGP 39551 exhibits maximal electroshock-induced seizures in mice with the ED50 of 4 mg/kg (p.o.)[2].
Following chronic neonatal treatment with CGP 39551, adult rats show increased behavioral responses to the D2 dopamine receptor stimulation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

237.19

Formula

C₈H₁₆NO₅P

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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CGP 39551
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