127910-32-1
127910-32-1
Chemical Structure
CGP 39551
- CAS No.: 127910-32-1
- Formula:C8H16NO5P
- Molecular Weight:237.19
IUPAC Name: (E)-(4-amino-5-ethoxy-2-methyl-5-oxopent-2-en-1-yl)phosphonic acid
InChIKey: OKDOWCKDTWNRCB-GQCTYLIASA-N
SMILES: CCOC(C(N)/C=C(C)/CP(O)(O)=O)=O
Biological Activity: CGP 39551 is a potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potent anticonvulsant activity[1]. CGP 39551 shows measurable inhibitory activity at both L-[3H]-glutamate (Ki=8.4 μM)[2].
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CGP 39551 | CGP 39551 is a potent, orally active, competitive N-methyl-D-aspartate (NMDA) receptor antagonist with potent anticonvulsant activity. CGP 39551 shows measurable inhibitory activity at both L-[3H]-glutamate (Ki=8.4 μM). | |||||||||||||||||||||
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References
- [1]. G E Fagg,et al. CGP 37849 and CGP 39551: novel competitive N-methyl-D-aspartate receptor antagonists with potent oral anticonvulsant activity. Prog Clin Biol Res. 1990;361:421-7. [Content Brief]
- [2]. G E Fagg, et al. CGP 37849 and CGP 39551: novel and potent competitive N-methyl-D-aspartate receptor antagonists with oral activity. Br J Pharmacol. 1990 Apr;99(4):791-7. [Content Brief]
Keywords
