SDZ 220-040
Based on 1 Customer Validation
SDZ 220-040 is a competitive the mammalian NMDA receptor antagonist with a pKi of 8.5. SDZ 220-040 can be used in the study of neurological diseases.
For research use only. We do not sell to patients.
- Purity: 99.14%
- CAS No.: 174575-40-7
- Formula: C16H16Cl2NO6P
- Molecular Weight:420.18
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All iGluR Isoforms
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Biological Activity
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NMDA Receptor 8.5 (pKi) |
SDZ 220-040 (20 μM; 9 days) induces a partially agravitropic pattern in Arabidopsis root architecture[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 174575-40-7
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Appearance Solid
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Molecular Weight 420.18
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Formula C16H16Cl2NO6P
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Color White to off-white
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SMILES
ClC1=C(C=CC(Cl)=C1)C2=CC(C[C@H](N)C(O)=O)=C(C(CP(O)(O)=O)=C2)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL (119.00 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Brian G Forde. et al. Glutamate signalling via a MEKK1 kinase-dependent pathway induces changes in Arabidopsis root architecture. Plant J. 2013 Jul;75(1):1-10. [Content Brief]
[2]. Urwyler S, et al. Biphenyl-derivatives of 2-amino-7-phosphono-heptanoic acid, a novel class of potent competitive N-methyl-D-aspartate receptor antagonists--II. Pharmacological characterization in vivo. Neuropharmacology. 1996 Jun;35(6):655-69. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3799 mL | 11.8997 mL | 23.7993 mL | 59.4983 mL |
| 5 mM | 0.4760 mL | 2.3799 mL | 4.7599 mL | 11.8997 mL | |
| 10 mM | 0.2380 mL | 1.1900 mL | 2.3799 mL | 5.9498 mL | |
| 15 mM | 0.1587 mL | 0.7933 mL | 1.5866 mL | 3.9666 mL | |
| 20 mM | 0.1190 mL | 0.5950 mL | 1.1900 mL | 2.9749 mL | |
| 25 mM | 0.0952 mL | 0.4760 mL | 0.9520 mL | 2.3799 mL | |
| 30 mM | 0.0793 mL | 0.3967 mL | 0.7933 mL | 1.9833 mL | |
| 40 mM | 0.0595 mL | 0.2975 mL | 0.5950 mL | 1.4875 mL | |
| 50 mM | 0.0476 mL | 0.2380 mL | 0.4760 mL | 1.1900 mL | |
| 60 mM | 0.0397 mL | 0.1983 mL | 0.3967 mL | 0.9916 mL | |
| 80 mM | 0.0297 mL | 0.1487 mL | 0.2975 mL | 0.7437 mL | |
| 100 mM | 0.0238 mL | 0.1190 mL | 0.2380 mL | 0.5950 mL |
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