Aptiganel hydrochloride
Based on 1 Customer Validation
Aptiganel hydrochloride (Cerestat) is a non-competitive NMDA receptor antagonist with neuroprotective effect.
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- Pureté : 99.89%
- CAS No.: 137160-11-3
- Formule: C20H22ClN3
- Masse moléculaire:339.86
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
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NMDA Receptor |
Chemical Information
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CAS No. 137160-11-3
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Appearance Solid
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Masse moléculaire 339.86
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Formule C20H22ClN3
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Color Off-white to light yellow
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SMILES
N=C(N(C)C1=CC=CC(CC)=C1)NC2=CC=CC3=C2C=CC=C3.Cl
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Synonyms
CNS 1102
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (294.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kroppenstedt SN, Schneider GH, Thomale UW, Unterberg AW. Neuroprotective properties of aptiganel HCL (Cerestat) following controlled cortical impact injury. Acta Neurochir Suppl. 1998;71:114-116. [Content Brief]
[2]. McBurney RN. Development of the NMDA ion-channel blocker, aptiganel hydrochloride, as a neuroprotective agent for acute CNS injury. Int Rev Neurobiol. 1997;40:173-195. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9424 mL | 14.7119 mL | 29.4239 mL | 73.5597 mL |
| 5 mM | 0.5885 mL | 2.9424 mL | 5.8848 mL | 14.7119 mL | |
| 10 mM | 0.2942 mL | 1.4712 mL | 2.9424 mL | 7.3560 mL | |
| 15 mM | 0.1962 mL | 0.9808 mL | 1.9616 mL | 4.9040 mL | |
| 20 mM | 0.1471 mL | 0.7356 mL | 1.4712 mL | 3.6780 mL | |
| 25 mM | 0.1177 mL | 0.5885 mL | 1.1770 mL | 2.9424 mL | |
| 30 mM | 0.0981 mL | 0.4904 mL | 0.9808 mL | 2.4520 mL | |
| 40 mM | 0.0736 mL | 0.3678 mL | 0.7356 mL | 1.8390 mL | |
| 50 mM | 0.0588 mL | 0.2942 mL | 0.5885 mL | 1.4712 mL | |
| 60 mM | 0.0490 mL | 0.2452 mL | 0.4904 mL | 1.2260 mL | |
| 80 mM | 0.0368 mL | 0.1839 mL | 0.3678 mL | 0.9195 mL | |
| 100 mM | 0.0294 mL | 0.1471 mL | 0.2942 mL | 0.7356 mL |
Aptiganel hydrochloride Related Classifications
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