NMDA receptor antagonist 9 

NMDA receptor antagonist 9 is a selective GluN2B subunit-containing NMDA receptor antagonist with a K_i of 5.2 nM. NMDA receptor antagonist 9 exhibits 9-fold selectivity over σ₁ receptors, shows poor selectivity towards σ₂ receptors. NMDA receptor antagonist 9 inhibits ion flux through GluN2B subunit-containing NMDA receptors. NMDA receptor antagonist 9 can be used for the research of neurological disease, such as alzheimer’s disease and parkinson’s disease^[1].

NMDA receptor antagonist 9 (Compound cis-15a) binds to GluN2B subunit-containing NMDA receptors in recombinant L(tk-) cells with a K_i of 5.2 ± 1.9 nM^[1].
NMDA receptor antagonist 9 (1 μM) inhibits ion flux at GluN2B subunit-containing NMDA receptors expressed in Xenopus laevis oocytes by 76 ± 2%^[1].
NMDA receptor antagonist 9 binds to σ₁ and σ₂ receptors in guinea pig brain membranes with a K_i of 49 ± 7 and 4.2 ± 0.6 nM^[1].
NMDA receptor antagonist 9 (90 min at 37 °C) exhibits high phase I metabolic stability in mouse liver microsomes, with 89 ± 6% intact after incubation^[1].
NMDA receptor antagonist 9 (90 min at 37 °C) retains high metabolic stability in mouse liver microsomes with NADPH and UDP-GA, with 88% intact after incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

323.43

C₂₁H₂₅NO₂

OC1=CC=C2C(C[C@@H]([C@@H]2O)N3CCC(CC3)CC4=CC=CC=C4)=C1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Korff M, et al. Stereoselective Synthesis of Conformationally Restricted γ- and β-Amino Alcohols as GluN2B Subtype-Selective NMDA Receptor Antagonists. J Med Chem. 2026;69(2):1671-1697.  [Content Brief]