1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. iGluR
  3. (S)-(-)-HA 966

(S)-(-)-HA 966 (Synonyms: (-)-HA 966)

Cat. No.: HY-100822A
Handling Instructions

(S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear.

For research use only. We do not sell to patients.

(S)-(-)-HA 966 Chemical Structure

(S)-(-)-HA 966 Chemical Structure

CAS No. : 111821-58-0

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Description

(S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2].

In Vitro

On cultured cortical neurones (+)-HA-966 inhibits glycine-potentiated NMDA responses with an IC50=13 μM compared with (-)-HA-966 (IC50=708 μM)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(S)-(-)-HA 966 ((-)-HA 966; 3 and 5 mg/kg; i.p.) prevents restraint stress-induced dopamine utilization in both the medial prefrontal cortex and nucleus accumbens. (S)-(-)-HA 966 suppresses fear-induced behaviors: immobility and defecation[1].
(S)-(-)-HA 966 (3 mg/kg; i.p.) prevents locomotor sensitization without altering the acute motoric response elicited by cocaine[1].
(S)-(-)-HA 966 (5 mg/kg; i.p.) blocks acute cocaine-induced locomotion but resulted in sedation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

116.12

Formula

C₄H₈N₂O₂

CAS No.
SMILES

O=C1N(O)CC[[email protected]@H]1N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: ≥98.0%

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Keywords:

(S)-(-)-HA 966(-)-HA 966iGluRIonotropic glutamate receptorsγ-HydroxybutyrateNMDAdopamineInhibitorinhibitorinhibit

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(S)-(-)-HA 966
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HY-100822A
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