111821-58-0
111821-58-0
Chemical Structure
(S)-(-)-HA 966
Synonym(s): (-)-HA 966
- CAS No.: 111821-58-0
- Formula:C4H8N2O2
- Molecular Weight:116.12
IUPAC Name: (S)-3-amino-1-hydroxypyrrolidin-2-one
InChIKey: HCKUBNLZMKAEIN-VKHMYHEASA-N
SMILES: O=C1N(O)CC[C@@H]1N
Biological Activity: (S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear[1][2].
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(S)-(-)-HA 966 | (S)-(-)-HA 966 ((-)-HA 966), a γ-Hydroxybutyrate-like agent, is weakly active as an NMDA-receptor antagonist. (S)-(-)-HA 966 possesses muscle relaxant action and prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear. | |||||||||||||||||||||
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References
- [1]. B A Morrow, et al. (S)-(-)-HA-966, a gamma-hydroxybutyrate-like agent, prevents enhanced mesocorticolimbic dopamine metabolism and behavioral correlates of restraint stress, conditioned fear and cocaine sensitization. J Pharmacol Exp Ther. 1997 Nov;283(2):712-21. [Content Brief]
- [2]. L Singh, et al. Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative. Proc Natl Acad Sci U S A. 1990 Jan;87(1):347-51. [Content Brief]
