2. GPCR/G Protein Neuronal Signaling
  3. mGluR
  4. LSN2463359

LSN2463359 is positive allosteric modulator of metabotropic glutamate 5 (mGlu5). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model. LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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LSN2463359 Chemical Structure

LSN2463359 Chemical Structure

CAS No. : 1401031-52-4

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Based on 1 publication(s) in Google Scholar

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Description

LSN2463359 is positive allosteric modulator of metabotropic glutamate 5 (mGlu5). LSN2463359 attenuates aspects of the behavioral response to administration of the competitive NMDA receptor antagonist. LSN2463359 selectively attenuates reversal learning deficits observed in the neurodevelopmental MAM E17 model[1]. LSN2463359 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

265.31

Formula

C16H15N3O
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=NC=C(C=C1)C#CC2=CC=NC=C2)NC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (471.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7692 mL 18.8459 mL 37.6918 mL
5 mM 0.7538 mL 3.7692 mL 7.5384 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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In Vivo Dissolution Calculator
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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.7692 mL 18.8459 mL 37.6918 mL 94.2294 mL
5 mM 0.7538 mL 3.7692 mL 7.5384 mL 18.8459 mL
10 mM 0.3769 mL 1.8846 mL 3.7692 mL 9.4229 mL
15 mM 0.2513 mL 1.2564 mL 2.5128 mL 6.2820 mL
20 mM 0.1885 mL 0.9423 mL 1.8846 mL 4.7115 mL
25 mM 0.1508 mL 0.7538 mL 1.5077 mL 3.7692 mL
30 mM 0.1256 mL 0.6282 mL 1.2564 mL 3.1410 mL
40 mM 0.0942 mL 0.4711 mL 0.9423 mL 2.3557 mL
50 mM 0.0754 mL 0.3769 mL 0.7538 mL 1.8846 mL
60 mM 0.0628 mL 0.3141 mL 0.6282 mL 1.5705 mL
80 mM 0.0471 mL 0.2356 mL 0.4711 mL 1.1779 mL
100 mM 0.0377 mL 0.1885 mL 0.3769 mL 0.9423 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LSN24633591401031-52-4LSN 2463359LSN-2463359mGluRMetabotropic glutamate receptorsmetabotropic glutamate 5NMDA receptorInhibitorinhibitorinhibit

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