Crocetin disodium
Based on 3 publication(s) in Google Scholar
Crocetin (Transcrocetin) disodium, extracted from saffron (Crocus sativus L.), acts as an NMDA receptor antagonist with high affinity.
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- Pureté : 99.30%
- CAS No.: 591230-99-8
- Formule: C20H22Na2O4
- Masse moléculaire:372.37
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Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Crocetin disodium
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Customer Validation & Images
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Cell Proliferation/Viability Assay
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IF
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Histological Imaging/Staining
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Flow Cytometry
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Activité biologique
Description
IC50 & Target
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NMDA Receptor |
In Vitro
Crocetin (Transcrocetin, trans-Crocetin) disodium, a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 µM) reveal no negative significant changes in cellular viability. Crocetin disodium at 10 µM level does not change viability while higher concentrations (40-160 µM) reduces significantly cellular viability[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 591230-99-8
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Appearance Solid
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Masse moléculaire 372.37
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Formule C20H22Na2O4
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Color Orange to reddish brown
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SMILES
O=C(O[Na])/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C(O[Na])=O
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Synonyms
Transcrocetin disodium; trans-Crocetin disodium
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (3)
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Journal Impact Factor
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Most Recent
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Int J Pharm X
RGD peptide-functionalized micelles loaded with crocetin ameliorate doxorubicin-induced cardiotoxicity. [Abstract]2025 Feb 26:9:100326. PMID: 40103672
Crocetin disodium purchased from MedChemExpress. Usage Cited in: Int J Pharm X. 2025 Feb 26:9:100326. [Abstract]
The protective analysis of RGD@M(Cro) nanoparticles containing different Crocetin (Cro) centrations (0, 2.5, 5, 10, 20, 40 μM) in HL-1 cells via CCK8 assay.
Crocetin disodium purchased from MedChemExpress. Usage Cited in: Int J Pharm X. 2025 Feb 26:9:100326. [Abstract]
TUNEL analysis of cell apoptosis treated with Cro, M(Cro), or RGD@ M(Cro) containing 40 μM Crocetin (Cro).
Crocetin disodium purchased from MedChemExpress. Usage Cited in: Int J Pharm X. 2025 Feb 26:9:100326. [Abstract]
The mice were administered Crocetin (Cro), M(Cro), or RGD@M(Cro) (20 mg/kg) for one week, followed by a single intraperitoneal injection of Dox (15 mg/kg) on the seventh day. H&E staining and Masson staining of cardiac tissue in mice.
Crocetin disodium purchased from MedChemExpress. Usage Cited in: Int J Pharm X. 2025 Feb 26:9:100326. [Abstract]
Flow cytometric analysis of HL-1 cells treated with M(Cro) or RGD@M(Cro) nanomicelles containing 20 μM Crocetin (Cro) for 2 h at 37 °C.
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Int Immunopharmacol
Rutin ameliorates hepatic ischemia-reperfusion injury by targeting CD36 to suppress hepatocyte ferroptosis. [Abstract]2026 Mar 1:172:116231. PMID: 41576568 -
J Phys Chem B
2026 Jan 8;130(1):205-214. PMID: 41404815
Solvant et solubilité
In Vitro:
H2O : ≥ 4.56 mg/mL (12.25 mM)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.6855 mL | 13.4275 mL | 26.8550 mL | 67.1375 mL |
| 5 mM | 0.5371 mL | 2.6855 mL | 5.3710 mL | 13.4275 mL | |
| 10 mM | 0.2686 mL | 1.3428 mL | 2.6855 mL | 6.7138 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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