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transport system

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5

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6

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Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W011777
    Tricaine methanesulfonate
    Maximum Cited Publications
    23 Publications Verification

    MS-222

    		 Biochemical Assay Reagents Neurological Disease
    Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures .
    Tricaine methanesulfonate
  • HY-B2132
    Tryptamine
    1 Publications Verification

    3-(2-Aminoethyl)indole~2-(3-Indolyl)ethylamine

    		 Endogenous Metabolite 5-HT Receptor Aryl Hydrocarbon Receptor Neurological Disease Metabolic Disease
    Tryptamine is a selective, blood-brain-penetrating 5-HT4 receptor agonist (EC50=1-3 mM) and an endogenous ligand of the aryl hydrocarbon receptor (AHR) (Kd=10-50 nM). Tryptamine promotes intestinal anion secretion and fluid transport by activating G protein-coupled receptors (GPCRs) and accelerates gastrointestinal motility. Tryptamine regulates Th17/Treg balance to inhibit neuroinflammation, competitively binds to 5-HT receptors to regulate central nervous system activity, and participates in temperature regulation and spinal reflex regulation as a neuromodulator. Tryptamine can be used to study intestinal motility disorders such as functional constipation, and has shown significant efficacy in multiple sclerosis models .
    Tryptamine
  • HY-N7131
    Coumarin 6
    20+ Cited Publications

    		 Fluorescent Dye Others
    Coumarin 6, a fluorescent dye, is used as a fluorescent probe in a microparticle drug delivery system to conduct in vivo tracking, cell uptake, and transport mechanism studies of drug delivery systems (λexc=450 nm, λem=505 nm) .
    Coumarin 6
  • HY-134452
    MeAIB
    4 Publications Verification

    α-(Methylamino)isobutyric acid

    		 Amino acid Transporter Cancer
    MeAIB (α-(Methylamino)isobutyric acid) is a specific?substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na +-dependent manner .
    MeAIB
  • HY-B0698A
    Ceftibuten dihydrate
    2 Publications Verification

    Sch-39720 dihydrate

    		 Beta-lactamase Bacterial Antibiotic Infection
    Ceftibuten (Sch-39720) dihydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .
    Ceftibuten dihydrate
  • HY-134427
    Palmitoyl coenzyme A lithium
    2 Publications Verification

    Palmitoyl CoA lithium

    		 Endogenous Metabolite Metabolic Disease
    Palmitoyl coenzyme A lithium is an acyl-CoA thioester that can be transported into the mitochondrial matrix via the carnitine shuttle system and is involved in β-oxidation. Palmitoyl coenzyme A lithium can also be used as a substrate for sphingosine biosynthesis .
    Palmitoyl coenzyme A lithium
  • HY-164036
    Lolamicin

    		Antibiotic Bacterial Infection
    Lolamicin is an orally effective inhibitor that specifically targets the Gram-negative bacteria lipoprotein transport system LolCDE complex. It selectively inhibits the transmembrane transport of outer membrane lipoproteins by competitively binding to lipoprotein binding sites. Lolamicin destroys the integrity of the bacterial outer membrane, leading to cell death, and has both bactericidal and antibacterial activity. It has significant effects on multidrug-resistant Enterobacteriaceae pathogens (such as Escherichia coli and Klebsiella pneumoniae). Lolamicin can be used to inhibit the study of acute pneumonia, sepsis and other infections caused by Gram-negative bacteria .
    Lolamicin
  • HY-D1005A6
    Poloxamer 124 (L44)

    PEG-PPG-PEG, 2200 (Average)

    		 Environmental Pollutants Biochemical Assay Reagents Others
    Poloxamer 124 L44 is a block polymer of polyoxyethylene and polyoxypropylene and a hydrophobic surfactant. Poloxamer 124 L44 causes eye irritation and exhibits oral toxicity in albino rats with an LD50 of 5 g/kg. Poloxamer 124 L44 has reversible adverse effects on triglyceride and cholesterol transport in the lymphatic system of rats. Poloxamer 124 L44 can form thermoreversible hydrogels and is used as a food additive and as a drug delivery vehicle in cosmetics, pharmaceuticals, and tissue engineering[1][2][3].
    Poloxamer 124 (L44)
  • HY-124617A
    AMXT-1501 tetrahydrochloride
    5+ Cited Publications

    		 Apoptosis Bacterial Infection Inflammation/Immunology Cancer
    AMXT-1501 tetrahydrochloride is a Bacterial agent and polyamine transport system inhibitor. AMXT-1501 tetrahydrochloride targets membrane phospholipids and exhibits antibacterial activity against a variety of Gram-positive and Gram-negative multidrug-resistant bacteria . AMXT-1501 tetrahydrochloride inhibits capsular biosynthesis in Streptococcus pneumoniae . AMXT-1501 tetrahydrochloride targets ornithine decarboxylase and polyamines to inhibit the proliferation of neuroblastoma cells . AMXT-1501 tetrahydrochloride in combination with DFMO (HY-B0744) induces Apoptosis in neuroblastoma cells. AMXT-1501 tetrahydrochloride is applicable to research related to multidrug-resistant bacterial infections, pneumococcal infections, Streptococcus pneumoniae infections, and neuroblastoma .
    AMXT-1501 tetrahydrochloride
  • HY-B1747
    Pyrithione
    5 Publications Verification

    		 Antibiotic Bacterial Fungal Infection
    Pyrithione is an inhibitor of membrane transport processes in fungi. Pyrithione is a potent antibiotic aspergillic acid. Pyrithion incubated Penicillium mycelia would have a marked decrease in the activities of a variety of independently regulated transport systems .
    Pyrithione
  • HY-124617
    AMXT-1501
    5+ Cited Publications

    		 Apoptosis Bacterial Infection Cancer
    AMXT-1501 is a Bacterial agent and polyamine transport system inhibitor. AMXT-1501 targets membrane phospholipids and exhibits antibacterial activity against a variety of Gram-positive and Gram-negative multidrug-resistant bacteria . AMXT-1501 inhibits capsular biosynthesis in Streptococcus pneumoniae . AMXT-1501 targets ornithine decarboxylase and polyamines to inhibit the proliferation of neuroblastoma cells . AMXT-1501 in combination with DFMO (HY-B0744) induces Apoptosis in neuroblastoma cells. AMXT-1501 is applicable to research related to multidrug-resistant bacterial infections, pneumococcal infections, Streptococcus pneumoniae infections, and neuroblastoma .
    AMXT-1501
  • HY-P4073
    ANG1005

    GRN1005; Paclitaxel trevatide

    		 Peptide-Drug Conjugates (PDCs) LDLR Cancer
    ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system .
    ANG1005
  • HY-114936
    Piericidin A
    5 Publications Verification

    AR-054

    		 Bacterial ADC Payload Antibiotic Mitochondrial Metabolism Infection Neurological Disease Cancer
    Piericidin A (AR-054) is a natural mitochondrial NADH-ubiquinone oxidoreductase (complex I) inhibitor. Piericidin A is a potent neurotoxin and inhibits mitochondrial respiration by disrupting the electron transport system through its action on NADH-ubiquinone reductase. Piericidin A is also a potential quorum-sensing inhibitor that suppresses the expression of the virulence genes of Erwinia carotovora subsp. atroseptica (Eca). Piericidin A is an ADC cytotoxin and has anti-bacterial, anticancer, insecticidal activity .
    Piericidin A
  • HY-D0180
    18-Crown-6-ether

    18C6; 1,4,7,10,13,16-Hexaoxacyclooctadecane

    		 Bacterial Infection
    18-Crown-6-ether is a type of crown ether compound and a specific structure dissociating agent. 18-Crown-6-ether can compete with K + for binding to G-quadruplexes, disrupting their stable structure to regulate the functions of related systems. 18-Crown-6-ether combines with K + and other metal ions to achieve precise ion transmembrane transport. 18-Crown-6-ether can act as an "susceptibility substrate" for the multi-drug efflux pump EmrE (a bacterial multidrug resistance transporter), ultimately inhibiting bacterial growth. 18-Crown-6-ether can be used in microcapsule controlled release and the research on developing antibacterial enhancers .
    18-Crown-6-ether
  • HY-N2368
    Arecaidine
    1 Publications Verification

    		 GABA Receptor Interleukin Related TGF-β Receptor TNF Receptor PPAR Neurological Disease
    Arecaidine is a GABA transport system inhibitor. Arecaidine inhibits the proliferation of oral mucosal fibroblasts, increases the secretion of IL-6, TGF-β and TNF-α in cells, downregulates the expression of PPAR-γ and PCK1 in cells, and upregulates the expression of TGF-β1 . Arecaidine inhibits the uptake of γ-aminobutyric acid and β-alanine by the central nervous system of cats . Arecaidine inhibits hPAT1-mediated L-[ 3H]proline uptake in cells. Arecaidine can be used in research related to neurological diseases .
    Arecaidine
  • HY-B0315A
    Biotin-Vitamin B12

    Biotin-Cyanocobalamin B12

    		 Endogenous Metabolite Metabolic Disease
    Biotin-Vitamin B12 (Biotin-Cyanocobalamin B12) is the biotinylated Vitamin B12 (HY-B0315). Vitamin B12 is a vitamin that can pass through the blood-brain barrier. Vitamin B12 plays a key role in the normal functioning of the brain and nervous system, and for the formation of blood. Vitamin B12 is beneficial for many inflammatory diseases and also provides protection in oxidative-stress-associated pathologies. Biotin-Vitamin B12 can be used in researches on vitamin B12 transport, cellular uptake, targeted delivery, analytical detection, and other areas .
    Biotin-Vitamin B12
  • HY-D0877
    TAPS

    		Biochemical Assay Reagents Connexin Others
    TAPS is an aminosulfonate-based lysozyme stabilizer and connexin channel inhibitor. TAPS maintains the native structure of lysozyme in aqueous solution at pH 7.0 and significantly protects it from heat-induced denaturation. TAPS directly inhibits the activity of heteromeric connexin 32/connexin 26 channels (Cx32/Cx26) via its protonated form, and this inhibitory effect is dependent on the presence of connexin 26. TAPS reduces connexin channel-mediated solute exchange in a recombinant liposome system, resulting in a decreased degree of liposome density shift in transport-specific separation assays. TAPS is a critical compound for investigating the structure and function of connexin channels .
    TAPS
  • HY-174166
    AqF026

    		Aquaporin Metabolic Disease
    AqF026 is an aquaporin 1 (AQP1) agonist. AqF026 enhances the channel activity of human AQP1 in the Xenopus laevis oocyte system. AqF026 enhances the osmotic transport of water across the peritoneum in a mouse model of peritoneal dialysis. AqF026 can be used in studies related to ultrafiltration failure in peritoneal dialysis .
    AqF026
  • HY-106031
    F-14512

    		Topoisomerase DNA/RNA Synthesis Cancer
    F-14512 is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 can be used to study breast cancer .
    F-14512
  • HY-W353469
    2-O-(α-D-Glucopyranosyl)glycerol (55% in water)

    Glucosylglycerol

    		 Biochemical Assay Reagents Others
    2-O-(α-D-Glucopyranosyl) glycerol (55% in water) (Glucosylglycerol) is a glycerol glycoside and compatible solute. 2-O-(α-D-Glucopyranosyl) glycerol is isolable from the marine cyanobacterium Oscillatoria sp. 2-O-(α-D-Glucopyranosyl) glycerol (55% in water) acts as a salt stress protectant in Synechocystis sp. PCC 6803 ΔggpS cells. It enhances salt tolerance of Synechocystis sp. PCC 6803 ΔggpS cells and maintains cell division under salt stress .
    2-O-(α-D-Glucopyranosyl)glycerol (55% in water)
  • HY-B2119
    Sodium tauroglycocholate

    Tauroglycocholic acid sodium salt

    		 Biochemical Assay Reagents Metabolic Disease
    Sodium tauroglycocholate (Tauroglycocholic acid sodium salt) is a multifunctional surfactant and penetration enhancer that can serve as a cholegraphic contrast agent. In organic solvents, Sodium tauroglycocholate embeds and stabilizes invertase by forming reverse micelles, and prolongs its active lifespan. In terms of transdermal absorption, Sodium tauroglycocholate effectively regulates the flux of aminophylline through snake slough by binding to keratin filaments, disrupting keratinocytes and altering lipid components of the stratum corneum. It exhibits rapid penetration characteristics without lag time at a concentration of 100 μg/mL. Sodium tauroglycocholate does not interfere with the hepatic uptake of Gd-EOB-DTPA by the bile acid transport system in rat hepatocytes .
    Sodium tauroglycocholate
  • HY-130840
    LolCDE-IN-2

    		Bacterial Cancer
    LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 inhibits E. coli MG1655 with a MIC of 2 μg/ml. Antibacterial activity .
    LolCDE-IN-2
  • HY-124009
    L-Cysteic acid

    		Endogenous Metabolite Metabolic Disease
    L-Cysteic acid is the oxidation product of L-cystine. L-Cysteic acid is a substrate of GADCase/CADCaseII. L-Cysteic acid has high affinity with CADCase I (Km = 0.22 mM). L-Cysteic acid is taken up by the synaptosome through a high affinity, Na +-dependent transport system .
    L-Cysteic acid
  • HY-131286A
    Talaglumetad (hydrochloride)

    LY-544344 (hydrochloride)

    		 Drug Derivative mGluR Neurological Disease
    Talaglumetad hydrochloride (LY-544344 hydrochloride) is an orally active prodrug of Eglumegad (HY-18941) and a metabotropic glutamate receptor 2/3 (mGluR2/3) agonist. Talaglumetad hydrochloride undergoes transmembrane transport via the intestinal peptide transporter hPepT1, and is enzymatically hydrolyzed to produce L-alanine and the parent drug Eglumegad after entering the body. Talaglumetad hydrochloride can be used in research related to metabotropic glutamate receptor 2-associated neurological systems .
    Talaglumetad (hydrochloride)
  • HY-D1478
    Fluorescent polyamine probe-1

    		Fluorescent Dye Others
    Fluorescent polyamine probe-1 (compound 15) is a linear polyamine probe with high uptake efficiency. Fluorescent polyamine probe-1 can be used for the research of transport system into cancer cells .
    Fluorescent polyamine probe-1
  • HY-B0698
    Ceftibuten

    Sch 39720

    		 Beta-lactamase Bacterial Antibiotic Infection
    Ceftibuten (Sch39720), an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .
    Ceftibuten
  • HY-P4668
    Valylleucine

    Val-Leu; H-Val-Leu-OH

    		 Bacterial Infection
    Valylleucine (Val-Leu; H-Val-Leu-OH) is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .
    Valylleucine
  • HY-P4668A
    Valylleucine TFA

    Val-Leu TFA; H-Val-Leu-OH TFA

    		 Bacterial Infection
    Valylleucine (Val-Leu; H-Val-Leu-OH) TFA is a branched-chain dipeptide that can enter cells independently via bacterial dipeptide transport systems, and is hydrolyzed by dipeptidases to release Val and Leu. Valylleucine TFA, as a model peptide, has its α-amino pK determined to be 7.90 by combining FDNB reaction kinetics with potentiometric titration .
    Valylleucine TFA
  • HY-124892A
    Acetylethylcholine mustard hydrochloride

    Acetyl-AF64

    		 Histone Acetyltransferase Neurological Disease
    Acetylethylcholine mustard hydrochloride (Acetyl-AF64) is an inhibitor of choline acetyl-transferase that reduces the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM. Acetylethylcholine mustard hydrochloride is an irreversible ligand for the high affinity choline transport system. Acetylethylcholine mustard hydrochloride is also a cholinotoxin. Acetylethylcholine mustard hydrochloride is a precursor for ethylcholine mustard aziridinium ion .
    Acetylethylcholine mustard hydrochloride
  • HY-W011777R
    Tricaine methanesulfonate (Standard)

    MS-222 (Standard)

    		 Biochemical Assay Reagents Reference Standards Neurological Disease
    Tricaine (methanesulfonate) (Standard) is the analytical standard of Tricaine (methanesulfonate). This product is intended for research and analytical applications. Tricaine methanesulfonate (MS-222) is common used to immobilize fish for marking or transport and to suppress sensory systems during invasive procedures .
    Tricaine methanesulfonate (Standard)
  • HY-121214
    Amisulbrom

    		Environmental Pollutants Apoptosis Fungal Reactive Oxygen Species (ROS) Mitochondrial Metabolism Infection Cardiovascular Disease
    Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
    Amisulbrom
  • HY-B0698B
    Ceftibuten monohydrate

    Sch 39720 monohydrate

    		 Beta-lactamase Bacterial Antibiotic Infection
    Ceftibuten (Sch39720) monohydrate, an antibiotic, is an orally active cephalosporin, possesses potent activity in vitro against a wide range of gram-negative and certain gram-positive pathogens .
    Ceftibuten monohydrate
  • HY-121959
    4-Acetylphenoxyacetic acid

    		Biochemical Assay Reagents Metabolic Disease
    4-Acetylphenoxyacetic acid is a phenoxyacetic acid derivative. 4-Acetylphenoxyacetic acid can be synthesized from para-acetyl phenol. 4-Acetylphenoxyacetic acid can be used to study phenylacetic acid transport system of Pseudomonas putida U through the aerobic catabolism of phenylacetic aced derivative .
    4-Acetylphenoxyacetic acid
  • HY-W783917
    Lead Ionophore IV

    		Biochemical Assay Reagents Endogenous Metabolite
    Lead Ionophore IV is an ionophore that has the activity of promoting metal ion transport. Lead Ionophore IV is often used in biological research to study the biological effects of lead ions and their effects on cell function. Lead Ionophore IV can also be used to develop drug delivery systems to improve the bioavailability of compounds.
    Lead Ionophore IV
  • HY-167657
    Tizolemide

    		Sodium Channel Cardiovascular Disease
    Tizolemide is a sulphonamide diuretic compound that has alkaline properties and is cleared by a tubular transport system. Tizolemide induces changes of passive transport components across the basolateral membrane of isolated frog skin .
    Tizolemide
  • HY-106031A
    F-14512 hydrochloride

    		Topoisomerase DNA/RNA Synthesis Cancer
    F-14512 hydrochloride is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 hydrochloride enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 hydrochloride exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 hydrochloride demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 hydrochloride could be used to study breast cancer .
    F-14512 hydrochloride
  • HY-124218
    S 863390

    		Antibiotic Others
    S 863390 is a compound with the ability to inhibit the intestinal uptake system, which can interact with the intestinal uptake system to inhibit the uptake of β-lactam antibiotics and small peptides while also being transported itself.
    S 863390
  • HY-128424
    4'-Deoxyphlorizin

    		GLUT Metabolic Disease
    4'-Deoxyphlorizin is an inhibitor of the glucose transport system. 4'-Deoxyphlorizi has good phlorizin hydrolase inhibitory activity with the Km value of 0.59 nM and the Ki value of 0.33 nM, respectively .
    4'-Deoxyphlorizin
  • HY-134452R
    MeAIB (Standard)

    α-(Methylamino)isobutyric acid (Standard)

    		 Amino acid Transporter Reference Standards Cancer
    MeAIB (Standard) is the analytical standard of MeAIB. This product is intended for research and analytical applications. MeAIB (α-(Methylamino)isobutyric acid) is a specific substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na+-dependent manner .
    MeAIB (Standard)
  • HY-155849
    PKM2-IN-4

    		Pyruvate Kinase Cancer
    Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling .
    PKM2-IN-4
  • HY-W019868
    1-O-Hexadecyl-2-O-acetyl-sn-glycerol

    		mTOR Others
    1-O-Hexadecyl-2-O-acetyl-sn-glycerol is an alkyl acylglycerol that may activate the amino acid transport activity of the A-system and stimulate the absorption of methylaminoisobutyric acid (MeAIB). MeAIB inhibits mTOR phosphorylation, which may affect intestinal amino acid absorption and signal transduction .
    1-O-Hexadecyl-2-O-acetyl-sn-glycerol
  • HY-124009R
    L-Cysteic acid (Standard)

    		Reference Standards Endogenous Metabolite Others
    L-Cysteic acid (Standard) is the analytical standard of L-Cysteic acid. This product is intended for research and analytical applications. L-Cysteic acid is the oxidation product of L-cystine. L-Cysteic acid is a substrate of GADCase/CADCaseII. L-Cysteic acid has high affinity with CADCase I (Km = 0.22 mM). L-Cysteic acid is taken up by the synaptosome through a high affinity, Na +-dependent transport system .
    L-Cysteic acid (Standard)
  • HY-103338
    AM1172

    		Others Neurological Disease
    AM1172 is metabolically stable anandamide uptake inhibitor. AM1172 inhibits [ 3H] anandamide transport in rat cortical neurons and human CCF-STTG1 astrocytoma cells with IC50 values of 2.1 μM and 2.5 μM, respectively. AM1172 can significantly inhibit AEA hydrolysis and concurrently decrease AEA uptake. AM1172 can be used for the study of endocannabinoid system regulation .
    AM1172
  • HY-W423573
    N,S-Diacetylcysteine methyl ester

    		Amino Acid Derivatives Others Metabolic Disease
    N,S-Diacetylcysteine ​​methyl ester is a cysteine ​​derivative that can increase the levels of intracellular cysteine ​​and glutathione. N,S-Diacetylcysteine ​​methyl ester is hydrolyzed by intracellular esterase to release cysteine, thereby promoting the synthesis of glutathione. Due to its acetylation properties, N,S-Diacetylcysteine ​​methyl ester has better cell membrane permeability and can enter the cell more effectively. N,S-Diacetylcysteine ​​methyl ester can be used to study the intracellular cysteine ​​and glutathione (GSH) transport system .
    N,S-Diacetylcysteine methyl ester
  • HY-151944
    Antibacterial agent 128

    		Bacterial Antibiotic Infection
    Antibacterial agent 128 is a siderophore analog-Ciprofloxacin (HY-B0356) conjugate with a cleavable linker. Antibacterial agent 128 shows antibiotic activities against P. aeruginosa (MIC values of 0.25-64 μg/mL) and B. pseudomallei (MIC values of 1-32 μg/mL) .
    Antibacterial agent 128
  • HY-172166B
    TRITC-lysine-dextran (MW 70kDa)

    		Fluorescent Dye Neurological Disease
    TRITC-lysine-dextran (MW 70kDa) is a fluorescent label prepared by the conjugation of TRITC (HY-D0791), lysine and dextran. TRITC-lysine-dextran (MW 70kDa) serves multiple functions as an axonal tracer, non-viral nanocarrier and fixable fluorescent clonal marker. TRITC-lysine-dextran (MW 70kDa) undergoes anterograde and retrograde transport within axons of sensory neurons, and acts as a non-viral delivery system to precisely deliver biomolecules to neurons. TRITC-lysine-dextran (MW 70kDa) remains stably retained during histological preparation, thereby supporting continuous observation in live or fixed samples .
    TRITC-lysine-dextran (MW 70kDa)
  • HY-W127487
    N-Octadecanoyl-L-homoserine lactone

    		Biochemical Assay Reagents Others
    Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C18-HSL, one of four lipophilic long acyl side chain AHLs produced by the LuxI AHL synthase homolog SinI, is involved in quorum-sensing signaling in strains of Rhizobium meliloti (a nitrogen-fixing bacterial symbiont of the legume M. sativa) . C18-HSL and other hydrophobic AHLs tend to localize in the relatively lipophilic environment of bacterial cells and cannot diffuse freely across the cell membrane. Long-chain N-acyl homoserine lactones can be exported from cells by efflux pumps, or can be transported between communicating cells by extracellular outer membrane vesicles.
    N-Octadecanoyl-L-homoserine lactone
  • HY-W795736
    (+)-Vesamicol

    (+)-AH5183

    		 nAChR Neurological Disease
    (+)-Vesamicol ((+)-AH5183) is an acetylcholine vesicular transport system inhibitor. (+)-Vesamicol blocks acetylcholine storage and uptake by synaptic vesicles, reducing transmitter availability for neuromuscular junction release. (+)-Vesamicol acts as a neuromuscular blocking agent, producing frequency-dependent neuromuscular block in rat hemidiaphragm preparations .
    (+)-Vesamicol
  • HY-D3196
    AG2

    		Fluorescent Dye Cancer
    AG2 is a glucose uptake tracer and two-photon fluorescent probe. AG2 is taken up by cells via glucose-specific transport systems, rather than passive diffusion; it preferentially accumulates in cancer cells and colon cancer tissues compared with normal cells and tissues; it mainly localizes to mitochondria, with a small amount also distributed in the cytoplasm and cell membrane. AG2 can be used for colon cancer research .
    AG2
  • HY-186106
    3-Deoxyanguibactin

    		Bacterial Infection
    3-Deoxyanguibactin is a siderophore and Fe(III) chelator/iron delivery agent. 3-Deoxyanguibactin binds Fe(III) with 2:1 stoichiometry in liquid phase, delivers iron into Acinetobacter baumannii cells, and relies on the BauA outer membrane receptor and bau transport system for cellular entry. 3-Deoxyanguibactin can be used for the research of acinetobacter baumannii infection .
    3-Deoxyanguibactin

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