2. Metabolic Enzyme/Protease
  3. Pyruvate Kinase
  4. PKM2-IN-4

Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling.

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PKM2-IN-4

PKM2-IN-4 Chemical Structure

CAS No. : 2996165-24-1

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PKM2-IN-4 Related Antibodies

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Description

Pkm2-in-4 (compound 5C) is a selective inhibitor of PKM2 (IC50=0.35 μM), which regulates pyruvate-dependent respiration and induces mitochondrial H202 production rate and electron transport system coupling[1].

IC50 & Target

IC50: 0.35 μM (PKM2)[1]
Cellular Effect
Cell Line Type Value Description References
4T1 IC50
0.32 μM
Compound: 5c
Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against mouse 4T1 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37216812]
A549 IC50
1.3 μM
Compound: 5c
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37216812]
H9c2 IC50
2.46 μM
Compound: 5c
Cytotoxicity against rat H9c2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against rat H9c2 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37216812]
HCC1937 IC50
0.33 μM
Compound: 5c
Cytotoxicity against human HCC1937 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human HCC1937 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37216812]
Jurkat IC50
0.44 μM
Compound: 5c
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37216812]
MCF7 IC50
1.16 μM
Compound: 5c
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37216812]
MDA-MB-231 IC50
0.51 μM
Compound: 5c
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay
[PMID: 37216812]
Molecular Weight

453.62

Formula

C15H17BrClNO3Se
CAS No.
SMILES

BrC1=C([Se][N+]2=C1C=C(C(OC)=O)C=C2)C3(CCCCC3)O.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PKM2-IN-4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PKM2-IN-42996165-24-1Pyruvate KinaseInhibitorinhibitorinhibit

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