Mycosporine glycine
Mycosporine glycine (Mycosporine-Gly) is a mycosporine-like amino acid derived from marine organisms, which possesses free radical scavenging, antioxidant, anti-inflammatory and photoprotective activities. Mycosporine glycine inhibits the UV-induced upregulation of COX-2 mRNA and gene expression levels, scavenges free radicals, ROS and peroxyl radicals, and inhibits free radical chain lipid peroxidation and phosphatidylcholine peroxidation. Mycosporine glycine restores PCOLCE and elastin levels suppressed by ultraviolet radiation, alleviates photooxidative stress and UV-mediated skin cell damage. Mycosporine glycine can be used in studies related to UV-induced skin inflammation, skin photoaging and skin damage.
For research use only. We do not sell to patients.
- CAS No.: 65318-21-0
- Formula: C10H15NO6
- Molecular Weight:245.23
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
COX-2 |
In Vitro
Mycosporine glycine (M-Gly) acts as a cell-free DPPH radical scavenger with an IC50 value of 4.23 mM, and exhibits concentration-dependent activity within the range of up to 3.0 mM[1].
Mycosporine glycine exhibits potent ROS-scavenging activity[2].
Mycosporine glycine inhibits peroxyl radical-induced phosphatidylcholine auto-oxidation in a concentration-dependent manner in cell-free liposome assays[3].
Mycosporine glycine reacts with peroxy radicals generated by AAPH in tissue extracts of Lissoclinum patella and Palythoa tuberculosa[3].
Mycosporine glycine (0.03‑0.3 mM; 15 min UV exposure) exerts biological effects on UV‑irradiated HaCaT human keratinocytes: it inhibits UV‑induced COX‑2 expression at 0.3 mM, restores UV‑suppressed PCOLCE and elastin expressions, and reduces UV‑upregulated loricrin expression at 0.03 mM and 0.15 mM[1].
Mycosporine glycine (50 mM) increases the growth rate of the normal human skin fibroblast cell line TIG-114 by approximately 40%, and exerts no toxic effect on these cells after ultraviolet irradiation[2].
Mycosporine glycine restores the UV-inhibited expression of PCOLCE and elastin genes in human keratinocyte HaCaT cells in a concentration-dependent manner, and exhibits wound-healing activity[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:immortalized human keratinocyte HaCaT cells
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Concentration:0.03, 0.15, 0.3 mM
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Incubation Time:15 min (UV exposure; gene expression measured post-UV treatment)
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Result:Reduced UV‑provoked COX‑2 mRNA elevation to UV‑mock baseline at 0.3 mM, whereas 0.03 mM and 0.15 mM exerted negligible impacts on COX‑2 expression.
Restored UV‑repressed PCOLCE and elastin mRNA to or above UV‑mock baseline at 0.03 mM and 0.15 mM, counteracting UV‑driven suppression of skin‑aging‑associated genes.
Suppressed UV‑upregulated involucrin mRNA at 0.03 mM and 0.15 mM, diminishing its UV‑induced high expression.
Chemical Information
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CAS No. 65318-21-0
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Molecular Weight 245.23
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Formula C10H15NO6
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SMILES
OC(CNC1=C(C(C[C@@](O)(C1)CO)=O)OC)=O
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Synonyms
Mycosporine-Gly
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Structure Classification
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Initial Source
Palythoa tuberculosa
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mycosporine glycine Related Classifications
HY-N12630 Related Classifications
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