1. Anti-infection
  2. Bacterial
  3. LolCDE-IN-2

LolCDE-IN-2 

Cat. No.: HY-130840
Handling Instructions

LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 inhibits E. coli MG1655 with a MIC of 2 μg/ml. Antibacterial activity.

For research use only. We do not sell to patients.

LolCDE-IN-2 Chemical Structure

LolCDE-IN-2 Chemical Structure

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Description

LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 inhibits E. coli MG1655 with a MIC of 2 μg/ml. Antibacterial activity[1].

In Vitro

The P. aeruginosa ΔlolCDE::CTX-lolCDEE. colistrain becomes more susceptible to LolCDE-IN-2 (compound 2A) when either the MexAB-OprM efflux pump is lacking or the permeability of its OM is increased by the expression of the FpvA-ΔP protein; in each case, these strains show an MIC of 16 µg/ml[1].

Molecular Weight

367.40

Formula

C₂₂H₁₇N₅O

SMILES

C1(C2=NNC=C2C3=CC=NC=C3)=CC(OCC4=CN5C(C=C4)=NC=C5)=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LolCDE-IN-2BacterialLolCDEtransportsystemoutermembraneInhibitorinhibitorinhibit

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