Acetylethylcholine mustard hydrochloride
Acetylethylcholine mustard hydrochloride (Acetyl-AF64) is an inhibitor of choline acetyl-transferase that reduces the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM. Acetylethylcholine mustard hydrochloride is an irreversible ligand for the high affinity choline transport system. Acetylethylcholine mustard hydrochloride is also a cholinotoxin. Acetylethylcholine mustard hydrochloride is a precursor for ethylcholine mustard aziridinium ion.
For research use only. We do not sell to patients.
- CAS No.: 103994-00-9
- Formula: C8H17Cl2NO2
- Molecular Weight:230.13
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 103994-00-9
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Appearance Solid
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Molecular Weight 230.13
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Formula C8H17Cl2NO2
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Color Light brown to brown
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SMILES
CCN(CCOC(C)=O)CCCl.Cl
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Synonyms
Acetyl-AF64
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 50 mg/mL (217.27 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
[1]. Charoensook SN, et al. Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing. Integr Biol (Camb). 2017 Dec 11;9(12):956-967. [Content Brief]
[2]. Sutalangka C, et al. Laser acupuncture improves memory impairment in an animal model of Alzheimer's disease. J Acupunct Meridian Stud. 2013 Oct;6(5):247-51. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.3454 mL | 21.7268 mL | 43.4537 mL | 108.6342 mL |
| 5 mM | 0.8691 mL | 4.3454 mL | 8.6907 mL | 21.7268 mL | |
| 10 mM | 0.4345 mL | 2.1727 mL | 4.3454 mL | 10.8634 mL | |
| 15 mM | 0.2897 mL | 1.4485 mL | 2.8969 mL | 7.2423 mL | |
| 20 mM | 0.2173 mL | 1.0863 mL | 2.1727 mL | 5.4317 mL | |
| 25 mM | 0.1738 mL | 0.8691 mL | 1.7381 mL | 4.3454 mL | |
| 30 mM | 0.1448 mL | 0.7242 mL | 1.4485 mL | 3.6211 mL | |
| 40 mM | 0.1086 mL | 0.5432 mL | 1.0863 mL | 2.7159 mL | |
| 50 mM | 0.0869 mL | 0.4345 mL | 0.8691 mL | 2.1727 mL | |
| 60 mM | 0.0724 mL | 0.3621 mL | 0.7242 mL | 1.8106 mL | |
| 80 mM | 0.0543 mL | 0.2716 mL | 0.5432 mL | 1.3579 mL | |
| 100 mM | 0.0435 mL | 0.2173 mL | 0.4345 mL | 1.0863 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Acetylethylcholine mustard hydrochloride Related Classifications
HY-124892A Related Classifications
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