103994-00-9
Chemical Structure
Acetylethylcholine mustard hydrochloride
Synonym(s): Acetyl-AF64
- CAS No.: 103994-00-9
- Formula:C8H17Cl2NO2
- Molecular Weight:230.13
IUPAC Name: 2-((2-chloroethyl)(ethyl)amino)ethyl acetate hydrochloride
InChIKey: CHWPASAPXMNLKO-UHFFFAOYSA-N
SMILES: CCN(CCOC(C)=O)CCCl.Cl
Biological Activity: Acetylethylcholine mustard hydrochloride (Acetyl-AF64) is an inhibitor of choline acetyl-transferase that reduces the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM. Acetylethylcholine mustard hydrochloride is an irreversible ligand for the high affinity choline transport system. Acetylethylcholine mustard hydrochloride is also a cholinotoxin. Acetylethylcholine mustard hydrochloride is a precursor for ethylcholine mustard aziridinium ion[1][2].
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Acetylethylcholine mustard hydrochloride | Acetylethylcholine mustard hydrochloride (Acetyl-AF64) is an inhibitor of choline acetyl-transferase that reduces the contraction frequency of the myotubes by inhibiting the synthesis of acetylethylcholine (Ach) with the half-maximal inhibitory concentration (IC50) of 1.22 mM. Acetylethylcholine mustard hydrochloride is an irreversible ligand for the high affinity choline transport system. Acetylethylcholine mustard hydrochloride is also a cholinotoxin. Acetylethylcholine mustard hydrochloride is a precursor for ethylcholine mustard aziridinium ion. | |||||||||||||||||||||
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References
- [1]. Charoensook SN, et al. Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing. Integr Biol (Camb). 2017 Dec 11;9(12):956-967. [Content Brief]
- [2]. Sutalangka C, et al. Laser acupuncture improves memory impairment in an animal model of Alzheimer's disease. J Acupunct Meridian Stud. 2013 Oct;6(5):247-51. [Content Brief]
