F-14512 hydrochloride
F-14512 hydrochloride is an anticancer agent that utilizes the polyamine transport system (PTS) to selectively deliver polyamine-containing drugs to cancer cells. F-14512 hydrochloride enhances the affinity of polyamines for DNA, thereby inhibiting topoisomerase II and achieving selective cellular uptake. F-14512 hydrochloride exhibits significant cytotoxicity against cells with high PTS activity and induces DNA damage. F-14512 hydrochloride demonstrates potent antitumor activity in the MX1 breast tumor xenograft model. F-14512 hydrochloride could be used to study breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 866874-39-7
- Formula: C33H51Cl4N5O8
- Molecular Weight:787.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
F-14512 (0.001-100 μM) hydrochloride enters the cell through the polyamine transport system, in CHO cells with normal PTS, the IC50 is 0.12 μM, while in CHO-MG cells with defective PTS, the IC50 is 8.7 μM[1].
F-14512 (72 h) hydrochloride demonstrates high potency in multiple human cell lines (median IC50 = 0.18 μM) and is particularly effective against cell lines such as MX-1, LOX-IMV1, and HL-60[1].
F-14512 (1-100 μM, 1-24 h) hydrochloride induces DNA damage in A549 cells and exhibited stronger cytotoxicity in xrs6 cells with defective DNA repair[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MX-1 human breast cancer xenograft model established in homozygous female athymic nude mice[1]
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Dosage:0.16, 0.32, 0.63, 1.25 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily for 2 weeks
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Result:Led to tumor regression dose-dependently.
Chemical Information
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CAS No. 866874-39-7
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Molecular Weight 787.60
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Formula C33H51Cl4N5O8
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SMILES
O=C1[C@]2([H])[C@H](C3=CC(OC)=C(C(OC)=C3)O)C4=CC(OCO5)=C5C=C4[C@H]([C@@]2([H])CO1)NC(CNCCCNCCCCNCCCN)=O.Cl.Cl.Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
F-14512 hydrochloride Related Classifications
HY-106031A Related Classifications
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