2. Cytoskeleton Anti-infection Apoptosis Membrane Transporter/Ion Channel Stem Cell/Wnt
  3. Exosomes Bacterial Apoptosis Antibiotic Parasite Na+/H+ Exchanger (NHE) Fungal Wnt
  4. Monensin

Monensin  (Synonyms: Monensin A)

製品番号: HY-N4302 純度: 98.07%
COA 取扱説明書 Technical Support

Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects.

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CAS 番号 : 17090-79-8

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 404 在庫あり
Solution
10 mM * 1 mL in DMSO USD 404 在庫あり
Solid
5 mg $274 在庫あり
10 mg $410 在庫あり
25 mg $690 在庫あり
50 mg $980 在庫あり
100 mg $1300 在庫あり
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カスタマーレビュー

Based on 38 publication(s) in Google Scholar

Other Forms of Monensin:

Monensin 関連抗体

Top Publications Citing Use of Products

顧客検証

Cell Migration/Invasion Assay
Cell Imaging/Staining
WB
RT-PCR

    Monensin purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Dec 30;9(1):367.  [Abstract]

    Cellular BiP-IRF2BP2 interactions shown by Western blot analysis of co-immunoprecipitation in MG132-pretreated (5 μM, 0.5 h) Raw264.7 cells which were treated with acidized medium (AcM) or with AcM plus Monensin (0.1 μM) in the presence of LPS and MG132 (0.5 μM) for 6 h.

    Monensin purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2024 Dec 30;9(1):367.  [Abstract]

    Il1b expressions in BMDMs isolated from Hspa5f/f or Hspa5f/f; Lyz2-Cre mice treated with or without Monensin (1 μM), under stimulation of LPS for 24 h.

    Monensin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 18;16(1):6621.  [Abstract]

    The impact of different concentrations of monensin on the subcellular localization of YFP-ATG8e. 5-day-old YFP-ATG8e transgenic seedlings were treated with different concentrations of Monensin (5-40 μM; 1 h) in 1/2MS liquid medium, followed by confocal microscopy observation.

    Monensin purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 18;16(1):6621.  [Abstract]

    Detection of ROS generation after monensin treatment. 5-day-old mCherry-ATG8f seedlings were subjected to Monensin (20 μM; 1 h) treatment. The ROS-sensitive dye H2DCFDA (1 μM) was incubated 10 min prior to confocal imaging. The images were shown with LUT pseudocolor scale.

    Monensin purchased from MedChemExpress. Usage Cited in: Proc Natl Acad Sci U S A. 2025 Jul 15;122(28):e2501347122.  [Abstract]

    Boyden chamber transwell assays on mesenchymal NSCLC cells treated with indicated doses of Monensin (100-500 nM; 24 h). Migrated and invaded cells were quantified.

    Antibiotic アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    Parasite アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

    Wnt アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    Wnt1 Wnt3 Wnt5 Wnt7 Wnt11

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    Monensin (Monensin A), an orally active antibiotic, is an ionophore that mediates Na+/H+ exchange. Monensin is a potent Wnt signaling inhibitor. Monensin causes a marked enlargement of the multivesicular bodies (MVBs) and regulates exosome secretion. Monensin can be used for bacterial, fungal, and parasitic infections research, and shows anticancer effects[1][2][3][4].

    Cellular Effect
    Cell Line Type Value Description References
    Hepatocyte IC50
    < 0.001 1
    Compound: Monensin
    Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
    Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
    		[PMID: 18212104]
    BALB/3T3 IC50
    20.89 3
    Compound: MON
    Cytotoxicity against mouse BALB/3T3 cells
    Cytotoxicity against mouse BALB/3T3 cells
    		[PMID: 26338363]
    Hepatocyte IC50
    < 0.001 1
    Compound: Monensin
    Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
    Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
    		[PMID: 18212104]
    Hepatocyte IC50
    <0.001 1
    Compound: Monensin
    Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
    Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
    		[PMID: 18212104]
    Hepatocyte IC50
    < 0.001 1
    Compound: Monensin
    Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
    Antimicrobial activity against Plasmodium falciparum NF54 schizonts in mammalian hepatocytes after 96 hrs
    		[PMID: 18212104]
    Hepatocyte IC50
    < 0.001 1
    Compound: Monensin
    Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
    Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs
    		[PMID: 18212104]
    LoVo IC50
    1.09 3
    Compound: MON
    Antiproliferative activity against human LoVo cells
    Antiproliferative activity against human LoVo cells
    		[PMID: 26338363]
    MV4-11 IC50
    0.09 3
    Compound: MON
    Antiproliferative activity against human MV4-11 cells
    Antiproliferative activity against human MV4-11 cells
    		[PMID: 26338363]
    体外実験

    Monensin (1-5 μM; 48 h) results in a marked decrease in viability in a dose-dependent manner[1].
    Monensin (1-5 μM; 24 h) shows a statistically significant induction of apoptosis[1].
    Monensin (0.1-1 μM; 24 h) inhibits pEGFR and its downstream targets pAKT and pERK[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Monensin 関連抗体

    Cell Viability Assay[1]

    Cell Line: SCC9, SCC25, and GM-38 cell lines
    Concentration: 1-5 μM
    Incubation Time: 48 h
    Result: Resulted in a marked decrease in viability in a dose-dependent manner.

    Apoptosis Analysis[1]

    Cell Line: SCC25 cells
    Concentration: 1 μM, or 5 μM
    Incubation Time: 24 hours
    Result: Induced a potent apoptotic response.

    Western Blot Analysis[1]

    Cell Line: SCC9 and SCC25 cells
    Concentration: 0.1 μM, or 1 μM
    Incubation Time: 24 hours
    Result: Induced approximately a 50% inhibition of EGF-treated SCC9 cells with respect to pEGFR and its downstream targets pAKT and pERK.
    体内実験

    Monensin (10 mg/kg; po; daily; for 6 weeks) suppresses progression of the intestinal tumors without any sign of toxicity on normal mucosa in multiple intestinal neoplasia (Min) mice[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Multiple intestinal neoplasia (Min) mice (four-week-old) [2]
    Dosage: 10 mg/kg
    Administration: Orally application; daily; for 6 weeks
    Result: Suppressed progression of the intestinal tumors without any sign of toxicity on normal mucosa.
    分子量

    670.87

    分子式

    C36H62O11
    CAS 番号
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    C[C@]1([C@]2([H])O[C@@](CC2)([C@]3([H])O[C@]([C@@]4([H])O[C@](O)([C@@H](C[C@@H]4C)C)CO)([H])C[C@@H]3C)CC)O[C@@]5(CC1)O[C@]([C@@H]([C@H](C5)O)C)([H])[C@@H](C)[C@@H](OC)[C@H](C)C(O)=O
    Structure Classification
    Initial Source

    Streptomyces spp.
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    DMSO : 100 mg/mL (149.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.4906 mL 7.4530 mL 14.9060 mL
    5 mM 0.2981 mL 1.4906 mL 2.9812 mL
    10 mM 0.1491 mL 0.7453 mL 1.4906 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

    ×
    体積 （開始）

    V1

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    濃度 （終了）

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    体内:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.5 mg/mL (3.73 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
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    +
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    純度とドキュメンテーション
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 1.4906 mL 7.4530 mL 14.9060 mL 37.2650 mL
    5 mM 0.2981 mL 1.4906 mL 2.9812 mL 7.4530 mL
    10 mM 0.1491 mL 0.7453 mL 1.4906 mL 3.7265 mL
    15 mM 0.0994 mL 0.4969 mL 0.9937 mL 2.4843 mL
    20 mM 0.0745 mL 0.3727 mL 0.7453 mL 1.8633 mL
    25 mM 0.0596 mL 0.2981 mL 0.5962 mL 1.4906 mL
    30 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2422 mL
    40 mM 0.0373 mL 0.1863 mL 0.3727 mL 0.9316 mL
    50 mM 0.0298 mL 0.1491 mL 0.2981 mL 0.7453 mL
    60 mM 0.0248 mL 0.1242 mL 0.2484 mL 0.6211 mL
    80 mM 0.0186 mL 0.0932 mL 0.1863 mL 0.4658 mL
    100 mM 0.0149 mL 0.0745 mL 0.1491 mL 0.3727 mL
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    Monensin Related Classifications

    • Molarity Calculator

    • Dilution Calculator

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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Monensin17090-79-8Monensin AExosomesBacterialApoptosisAntibioticParasiteNa+/H+ Exchanger (NHE)FungalWntSodium/hydrogen ExchangerSodium-hydrogen ExchangerbioactiveionophoreStreptomycesprotonsmonovalentapoptosiscancerInhibitorinhibitorinhibit

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    製品番号:
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