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Results for "

β-glucuronidase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	β-glucuronidase (43) ADC Linker (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (3) Bacterial (8) Biochemical Assay Reagents (6) Carbonic Anhydrase (3) Carboxylesterase (CES) (1) Cholinesterase (ChE) (1) Cytochrome P450 (1) DNA/RNA Synthesis (1) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (3) Drug-Linker Conjugates for ADC (1) Endogenous Metabolite (1) Fluorescent Dye (7) Glycosidase (1) Herbicide (1) Influenza Virus (1) Isotope-Labeled Compounds (1) Phosphatase (2) Photosensitizer (1) Platelet-activating Factor Receptor (PAFR) (1) RSV (1) Topoisomerase (2)
By Research Areas:	Cancer (14) Cardiovascular Disease (1) Infection (6) Inflammation/Immunology (9) Metabolic Disease (16) Neurological Disease (3)
Click Chemistry:	Azide (1)

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Targets Recommended: β-glucuronidase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P2803

Beta-glucuronidase (Escherichia coli) 1 Publications Verification	β-glucuronidase	Metabolic Disease
Beta-glucuronidase is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-134453A

D-Saccharic acid 1,4-lactone hydrate 1 Publications Verification	β-glucuronidase Apoptosis	Cancer
D-Saccharic acid 1,4-lactone hydrate is an orally active *β-glucuronidase* inhibitor (IC₅₀=48.4 μM). D-Saccharic acid 1,4-lactone hydrate can be used as a standard agent compared with novel β-glucuronidase inhibitors. D-Saccharic acid 1,4-lactone hydrate possesses anticarcinogenic, detoxifying, and antioxidant properties .

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate 1 Publications Verification MUG	β-glucuronidase Fluorescent Dye	Others
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-P2803A

Beta-glucuronidase (bovine liver) 1 Publications Verification	β-glucuronidase	Metabolic Disease
Beta-glucuronidase (bovine liver) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-P2803B

Beta-glucuronidase (helix pomatia) 1 Publications Verification	β-glucuronidase	Metabolic Disease
Beta-glucuronidase (helix pomatia) is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium	Drug Metabolite	Others
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-173639

AZD0516	Antibody-Drug Conjugates (ADCs) Topoisomerase Apoptosis	Cancer
AZD0516 is a first-in-class antibody-drug conjugate (ADC) targeting six-transmembrane epithelial antigen of the prostate-2 (STEAP2). The anti-STEAP2 monoclonal antibody (mAb) is conjugated via interchain cysteines to a maleimide-reactive, β-glucuronidase-cleavable linker (HY-173635) bearing the topoisomerase 1 inhibitor, Exatecan (HY-13631). AZD0516 can be used for the study of prostate cancer .

HY-15935B

*X-Gluc* cyclohexanamine**	β-glucuronidase Fluorescent Dye	Others
X-Gluc cyclohexanamine is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc cyclohexanamine can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc cyclohexanamine is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-W039892

4-Nitrophenyl β-D-glucuronide 1 Publications Verification pNPG_1	β-glucuronidase	Others
4-Nitrophenyl β-D-glucuronide (pNPG_1) is aderivative of 4-Nitrophenol. 4-Nitrophenyl β-D-glucuronide is the chromogenic substrate for *β-glucuronidase* .

HY-W345885

Saccharic acid	β-glucuronidase	Metabolic Disease
Saccharic acid is a competitive and potent inhibitor of *β-glucuronidase*. Saccharic acid inhibits glucuronide synthesis. Saccharic acid as an efficient iron chelate to enhance photo-Fenton degradation of organic contaminants .

HY-15935C

*X-Gluc* sodium**	β-glucuronidase Fluorescent Dye	Others
X-Gluc sodium is a dye reagent for the detection of *β-glucuronidase* (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-103081

β-Glucuronidase-IN-1 1 Publications Verification	β-glucuronidase Bacterial	Infection Cancer
β-Glucuronidase-IN-1 is a potent, selective, uncompetitive, and orally active E. coli bacterial β-glucuronidase inhibitor, exhibiting an IC₅₀ and a K_i of 283 nM and 164 nM, respectively .

HY-15935

*X-Gluc* Dicyclohexylamine**	β-glucuronidase Fluorescent Dye	Others
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-D0164

Naphthol AS-BI	Fluorescent Dye β-glucuronidase	Others
Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.

HY-148044

UNC10201652	β-glucuronidase Bacterial	Infection
UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC₅₀ value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes .

HY-N7529

Siastatin B	Endogenous Metabolite β-glucuronidase	Others
Siastatin B is an effective broad-spectrum glycosidase inhibitor that can effectively inhibit the activities of sialidase, *β-D-glucuronidase, N-acetyl-glucosaminidase, β-glucuronidase, and human heparinase* .

HY-N1733

2′-Hydroxydaidzein 2 Publications Verification	β-glucuronidase	Inflammation/Immunology
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-D0935

4-Methylumbelliferyl-β-D-glucuronide 1 Publications Verification	β-glucuronidase Fluorescent Dye	Others
4-Methylumbelliferyl-β-D-glucuronide is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-151168

3-Chlorogentisyl alcohol	β-glucuronidase Bacterial	Inflammation/Immunology Cancer
3-Chlorogentisyl alcohol is a potent E. coli *β-glucuronidase* inhibitor with an IC₅₀ value of 0.74 μM, an K_i value of 0.58 μM. 3-Chlorogentisyl alcohol shows antiproliferative activity. 3-Chlorogentisyl alcohol has the potential for the research of anti-cancer and anti-inflammatory therapies .

HY-N1735

2′-Hydroxygenistein 2 Publications Verification	β-glucuronidase Bacterial	Inflammation/Immunology
2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of *β-glucuronidase* and lysozyme from rat neutrophils, with IC₅₀ values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively .

HY-N16039

TAN-1030A	β-glucuronidase	Inflammation/Immunology
TAN-1030A is an indolocarbazole alkaloid with macrophage-activating properties. TAN-1030A induces spreading of a murine macrophage cell line, Mm 1, and augmentes the phagocytic activity, Fc gamma receptor expression and β-glucuronidase activity of murine macrophage cell lines, Mm 1 and J774A.1. TAN-1030A can activate macrophage functions in mice .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Others	Inflammation/Immunology
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-D1460

Fluorescein Di-β-D-Glucuronide	Bacterial β-glucuronidase	Infection
Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .

HY-161341

β-Glucuronidase responsive conjugate 1	Photosensitizer	Cancer
β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC₅₀ of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers .

HY-W154341

3-Indolyl-β-D-glucuronide cyclohexanamine	Biochemical Assay Reagents	Others
3-Indolyl-β-D-glucuronide cyclohexanamine is the glucose component of X-Gluc staining buffer. 3-Indolyl-β-D-glucuronide cyclohexanamine can be used to detect gene expression. The active ingredient of the stain, β-Glucuronidase (GUS), reacts with the enzyme, causing the target gene to appear blue-purple in tissues or cells, so that the expression level and tissue distribution of the gene can be visually observed .

HY-N9970

Apigenin 7-O-β-D-glucuronide ethyl ester	Others	Inflammation/Immunology
Apigenin 7-O-β-D-glucuronide ethyl ester is a flavonoid glucuronate ester that can be isolated from Scutellaria regeliana. Apigenin 7-O-β-D-glucuronide ethyl ester possesses anti-inflammatory activity on the release of β-glucuronidase from rat polymorphonuclear leukocytes (PNMs) induced by platelet activating-factor. Apigenin 7-O-β-D-glucuronide ethyl ester can be used for anti-inflammatory research .

HY-137426A

Phenolphthalein glucuronide sodium	Biochemical Assay Reagents β-glucuronidase	Others
Phenolphthalein glucuronide sodium is a substrate to determine the β –glucuronidase .

HY-N1322

Sanggenol A	Bacterial β-glucuronidase	Others
Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .

HY-173703

β-Glu-PAB(CH2NH2)-Exatecan	Topoisomerase Drug Intermediate	Cancer
β-Glu-PAB(CH2NH2)-Exatecan (Compound 9a) is a topoisomerase I inhibitor. β-Glu-PAB(CH2NH2)-Exatecan binds to the topoisomerase I-DNA complex to prevent DNA strand reconnection, thereby inducing DNA breakage and cell apoptosis. β-Glu-PAB(CH2NH2)-Exatecan can be specifically cleaved by β-glucuronidase highly expressed in the tumor microenvironment to release Exatecan for cytotoxic effect. β-Glu-PAB(CH2NH2)-Exatecan is also an intermediate of Mal((3S,3aR,6S,6aR) -hexahydrofuro [3, 2-B]furan-3,6-diamine-PEG12)-β -Glu-Pab-Exatecan. β-Glu-PAB(CH2NH2)-Exatecan is promising for research of cancers .

HY-150973

hCAII-IN-4	Carbonic Anhydrase β-glucuronidase	Neurological Disease Metabolic Disease Cancer
hCAII-IN-4 (Compound 12j) is a potent hCA II inhibitor with an IC₅₀ of 7.78 μM. hCAII-IN-4 also inhibits *β-glucuronidase* with an IC₅₀ of 773.9 μM .

HY-N2998

Ganoderenic acid A	β-glucuronidase	Metabolic Disease
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of *β-glucuronidase*. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N9975

4'',5''-Dehydroisopsoralidin	β-glucuronidase	Inflammation/Immunology Cancer
4'',5''-Dehydroisopsoralidin is a *β-glucuronidase* inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners .

HY-150977

β-Glucuronidase/hCAII-IN-2	Carbonic Anhydrase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 670.7 μM and 21.77 μM, respectively .

HY-173635

Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB	ADC Linker	Cancer
Mal((3S,3aR,6S,6aR)-Hexahydrofuro[3,2-b]furan-3,6-diamine-PEG12)-β-Glu-PAB is an interchain cysteines to a Maleimide-reactive, β-glucuronidase-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs), such as AZD0516 (HY-173639) .

HY-N3413

Kushenol X	Carboxylesterase (CES) β-glucuronidase	Metabolic Disease
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent *β-glucuronidase* and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-150976

β-Glucuronidase/hCAII-IN-1	Carbonic Anhydrase β-glucuronidase	Neurological Disease Metabolic Disease Cancer
β-Glucuronidase/hCAII-IN-2 (Compound 12e) is a potent *β-glucuronidase* and hCA II inhibitor with an IC₅₀ of 440.1 μM and 4.91 μM, respectively .

HY-155313

β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE	Drug-Linker Conjugates for ADC	Cancer
β-Glucuronide-NB-bis[N(Me)-methyl ester]-MMAE (compound 20) is auristatins-glucuronide conjugate. Antitumor agent-122 shows in vitro antiproliferative activities against β-glucuronidase pretreated and untreated cancer cells with an IC₅₀ value of 5.7 nM - 9.7 nM. Antitumor agent-122 shows potent antitumor efficacy in HCT-116 xenograft mouse model without inducing side effects .

HY-173397

β-Glucuronidase-IN-3	β-glucuronidase Bacterial	Metabolic Disease
β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric *β-glucuronidase* inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC₅₀: 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs) .

HY-162884

β-Glucuronidase-IN-4	β-glucuronidase	Infection
EcGUS-IN-1 (Compound E-9) is a non-competitive *β-glucuronidase* inhibitor, with an IC₅₀ of 2.68 μM and a K_i value of 1.64 μM. EcGUS-IN-1 can improve gastrointestinal adverse events (GIAE) caused by Escherichia coli infection by inhibiting E. coli *β-glucuronidase* activity .

HY-N17236

Forsyshiyanine A	β-glucuronidase Influenza Virus RSV	Infection
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of *β-glucuronidase* from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-P2803D

β-Glucuronidase, Abalone	β-glucuronidase	Metabolic Disease
β-Glucuronidase, Abalone is a glycosyl hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, and then releases β-glucuronate .

HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide-d3 sodium	Isotope-Labeled Compounds Drug Metabolite	Others
Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-D1578

C12FDGlcU	Fluorescent Dye β-glucuronidase	Others
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

HY-137816

6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium	β-glucuronidase	Others
6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt is a chromogenic substrate for *β-glucuronidase*. 6-Chloro-3-indolyl-β-D-glucuronide cyclohexylammonium salt produces a salmon colored precipitate upon cleavage .

HY-W472153

β-Glucuronidase-IN-5	β-glucuronidase	Inflammation/Immunology Cancer
β-Glucuronidase-IN-5 (Compound 19; Compound 5c) is a β-glucuronidase inhibitor with an IC₅₀ of 39.8 μM. β-Glucuronidase-IN-5 does not show significant cytotoxicity towards PC-3 cells, with its IC₅₀ > 30 μM. β-Glucuronidase-IN-5 shows no affinity for adenosine receptors (A₁ and A₂A receptors). β-Glucuronidase-IN-5 can be used to study diseases related to excessive expression of β-glucuronidase (such as colon cancer, arthritis, and AIDS complications) .

HY-119621

Aceglatone	β-glucuronidase DNA/RNA Synthesis Apoptosis	Cancer
Aceglatone, an antineoplastic agent, is a *β-glucuronidase* inhibitor. Aceglatone is a compound that inhibits colon carcinogenesis and prevents the induction of colon cancer by inhibiting the hydrolysis of glucuronides. Aceglatone reduces cell proliferation, induces apoptosis and inhibits DNA synthesis in human colon cancer cells .

HY-137783

Resorufin β-D-glucuronide sodium	Biochemical Assay Reagents β-glucuronidase	Others
Resorufin β-D-glucuronide sodium can be used as a substrate for β-glucuronidase .

HY-137522A

Zidovudine O-β-D-glucuronide 3'-Azido-3'-deoxythymidine β-D-glucuronide	Drug Metabolite	Others
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

HY-N2247A

(+)-Guaiacin	Platelet-activating Factor Receptor (PAFR)	Metabolic Disease
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .

HY-W283888

5-Bromo-4-chloro-1H-indol-3-yl nonanoate	Biochemical Assay Reagents β-glucuronidase	Others
5-Bromo-4-chloro-1H-indol-3-yl nonanoate is a fluorescent substrate used to detect enzymes. The substrate reacts with various enzymes to produce a fluorescent product, which has been shown to be active against β-galactosidase, α-chymotrypsin, and β-glucuronidase.

Cat. No.	Product Name	Type

HY-D0935A

4-Methylumbelliferyl-β-D-glucuronide hydrate 1 Publications Verification MUG	Fluorescent Dyes
4-Methylumbelliferyl-β-D-glucuronide hydrate is a fluorogenic substrat (λ_ex=362 nm, λ_em=445 nm). 4-Methylumbelliferyl-β-D-glucuronide hydrate has potential applications in detecting the activity of β-glucuronidase and the number of Escherichia coli .

HY-173639

AZD0516

Fluorescent Dyes

AZD0516 is a first-in-class antibody-drug conjugate (ADC) targeting six-transmembrane epithelial antigen of the prostate-2 (STEAP2). The anti-STEAP2 monoclonal antibody (mAb) is conjugated via interchain cysteines to a maleimide-reactive, β-glucuronidase-cleavable linker (HY-173635) bearing the topoisomerase 1 inhibitor, Exatecan (HY-13631). AZD0516 can be used for the study of prostate cancer .

HY-15935C

X-Gluc sodium

Fluorescent Dyes

X-Gluc sodium is a dye reagent for the detection of β-glucuronidase (GUS), an enzyme produced by E. coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract (GUS as a specific detection indicator). X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (reacts with the GUS gene, appears blue) .

HY-15935

*X-Gluc* Dicyclohexylamine**	Fluorescent Dyes
X-Gluc Dicyclohexylamine is a dye reagent for the detection of β-glucuronidase, an enzyme produced by Escherichia coli. X-Gluc sodium can be used to detect E. coli contamination in food, water and the urinary tract. X-Gluc sodium is also widely used in molecular biology experiments to label and detect the expression of target genes (GUS reporter system) .

HY-D0164

Naphthol AS-BI	Fluorescent Dyes
Naphthol AS-BI is a substrate of β-glucuronidase and produces a bright red effect after staining biological tissues.

HY-D1460

Fluorescein Di-β-D-Glucuronide

Fluorescent Dyes

Fluorescein Di-β-D-Glucuronide is an orally active fluorescent probe substrate and an indicator of β-glucuronidase (βG) activity in intestinal bacteria. Fluorescein Di-β-D-Glucuronide can be used for non-invasive time-lapse optical imaging of βG activity in intestinal bacteria in nude mice. Fluorescein Di-β-D-Glucuronide supports the quantitative analysis of bacterial βG enzyme activity and inhibition .

HY-D1578

C12FDGlcU	Fluorescent Dyes
C12FDGlcU is a lipophilic analog of fluorescein di-β-D-glucuronic acid. C12FDGlcU can be useful for the detection of *β-glucuronidase* (GUS) gene expression. C12FDGlcU can enter the cells and then be cleaved by β-glucuronidase, generating the yellow-colored, green-fluorescent fluorescein (Abs/Em of the reaction product: 495/518 nm) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W345885

Saccharic acid	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	β-glucuronidase
Saccharic acid is a competitive and potent inhibitor of *β-glucuronidase*. Saccharic acid inhibits glucuronide synthesis. Saccharic acid as an efficient iron chelate to enhance photo-Fenton degradation of organic contaminants .

HY-N1733

2′-Hydroxydaidzein 2 Publications Verification	Flavonoids Leguminosae Crotalaria pallida Ait. Plants Isoflavones Source Classification	β-glucuronidase
2′-Hydroxydaidzein is a metabolite. 2′-Hydroxydaidzein inhibits the release of chemical mediator from inflammatory cells. 2′-Hydroxydaidzein significantly inhibits lysozyme and β-glucuronidase release from rat neutrophils, which is stimulated with fMLP/CB, respectively .

HY-N1735

2′-Hydroxygenistein 2 Publications Verification	Flavonoids Leguminosae Crotalaria pallida Ait. Plants Isoflavones Source Classification	β-glucuronidase Bacterial
2′-Hydroxygenistein is a natural product that can be isolated from Crotalaria pallida and C. assamica. 2′-Hydroxygenistein shows anti-inflammatory activity. 2′-Hydroxygenistein shows significant concentration-dependent inhibitory effects on the release of *β-glucuronidase* and lysozyme from rat neutrophils, with IC₅₀ values of 5.9 ± 1.4 and 9.7 ± 3.5 μM, respectively .

HY-N16039

TAN-1030A	Alkaloids Microorganisms Indole Alkaloids Source Classification	β-glucuronidase
TAN-1030A is an indolocarbazole alkaloid with macrophage-activating properties. TAN-1030A induces spreading of a murine macrophage cell line, Mm 1, and augmentes the phagocytic activity, Fc gamma receptor expression and β-glucuronidase activity of murine macrophage cell lines, Mm 1 and J774A.1. TAN-1030A can activate macrophage functions in mice .

HY-N6851

Glycyrrhetic acid 3-O-β-D-glucuronide Glycyrrhetic acid 3-O-mono-β-D-glucuronide; 3-monoglucuronyl-glycyrrhetinic acid	Triterpenes Classification of Application Fields Leguminosae Terpenoids Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Sweeteners Source Classification Food Research	Others
Glycyrrhetic acid 3-O-β-D-glucuronide, isolated from glycyrrhiza, is an important derivative of glycyrrhizin (GL) with an anti -allergic activity . Glycyrrhetic acid 3-O-β-D-glucuronide (GAMG) shows that β-glucuronidases (β-GUS) are key GAMG-producing enzymes, displaying a high potential to convert GL directly into GAMG .Glycyrrhetic acid 3-O-β-D-glucuronide is valuable as a sweetener.

HY-N9970

Apigenin 7-O-β-D-glucuronide ethyl ester	Structural Classification Flavonoids Scutellaria regeliana Nakai Flavones Labiatae Plants Source Classification	Others
Apigenin 7-O-β-D-glucuronide ethyl ester is a flavonoid glucuronate ester that can be isolated from Scutellaria regeliana. Apigenin 7-O-β-D-glucuronide ethyl ester possesses anti-inflammatory activity on the release of β-glucuronidase from rat polymorphonuclear leukocytes (PNMs) induced by platelet activating-factor. Apigenin 7-O-β-D-glucuronide ethyl ester can be used for anti-inflammatory research .

HY-N1322

Sanggenol A	Structural Classification Flavonoids Flavones Plants Moraceae Morus alba Linn. Source Classification	Bacterial β-glucuronidase
Sanggenol A acts as a dual inhibitor of nitrofuranone reduction mediated by the intestinal microbial nitrification reductases EcNfsA and EcNfsB. In addition, Sanggenol A is also an effective inhibitor of intestinal bacterial β-glucuronidase .

HY-N2998

Ganoderenic acid A	Triterpenes Structural Classification Human Gut Microbiota Metabolites other families Classification of Application Fields Terpenoids Metabolic Disease Plants Endogenous metabolite Disease Research Fields Source Classification	β-glucuronidase
Ganoderenic acid A is a lanostane-type triterpene. Ganoderenic acid A is a potent inhibitor of *β-glucuronidase*. Ganoderenic acid A has a potent hepatoprotective effect against CCl4-induced liver injury .

HY-N9975

4'',5''-Dehydroisopsoralidin	Classification of Application Fields Solanum lyratum Thunberg Coumarins Phenylpropanoids Solanaceae Plants Inflammation/Immunology Disease Research Fields Cancer	β-glucuronidase
4'',5''-Dehydroisopsoralidin is a *β-glucuronidase* inhibitor (IC₅₀: 6.3 μM). 4'',5''-Dehydroisopsoralidin has anti-inflammatory and anti-oxidative effects. 4'',5''-Dehydroisopsoralidin can be used in the research of inflammation and cancners .

HY-N3413

Kushenol X	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Metabolic Disease Sophora flavescens Aiton Plants Disease Research Fields Source Classification	Carboxylesterase (CES) β-glucuronidase
Kushenol X, a flavonoid compound isolated from the roots of Sophora flavescens. Kushenol X is a potent *β-glucuronidase* and human carboxylesterase 2 (hCE2) inhibitor with IC₅₀s of 2.07 μM and 3.05 μM, respectively .

HY-N17236

Forsyshiyanine A	Structural Classification Alkaloids Oleaceae Pyridine Alkaloids Forsythia suspensa (Thunb.) Vahl Plants Source Classification	β-glucuronidase Influenza Virus RSV
Foryshiyanine A is a triterpenoid alkaloid. Foryshiyanine A possesses anti-inflammatory activity, inhibiting the release of *β-glucuronidase* from rat polymorphonuclear leukocytes. Foryshiyanine A exhibits antiviral activity, with an EC₅₀ of 4.5 μM against respiratory syncytial virus (RSV) and an IC₅₀ of 7.3 μM against influenza A virus (H1N1). Foryshiyanine A reduces viral load by disrupting viral replication and entry. Foryshiyanine A may be used for the researches of inflammation and infection .

HY-N2247A

(+)-Guaiacin	Classification of Application Fields Lignans Phenols Polyphenols Metabolic Disease Phenylpropanoids Plants Lauraceae Machilus wangchiana Chun Disease Research Fields Source Classification	Platelet-activating Factor Receptor (PAFR)
(+)-Guaiacin is a compound extracted of the bark of Machilus wangchiana Chun. (Lauraceae). (+)-Guaiacin shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF) .

HY-119609

Ilicicolin C	Structural Classification Microorganisms Antibiotics Source Classification	Bacterial Cholinesterase (ChE) β-glucuronidase
Ilicicolin C exhibits antibacterial activity against Pseudomonas syringae with IC₅₀ of 28.5 µg/mL. Ilicicolin C exhibits weak inhibitory activities against acetylcholinesterase (AChE) and *β-glucuronidase* with IC₅₀ of 30-43 µg/mL. Ilicicolin C exhibits weak cytoxicity in human lung fibroblasts with IC₅₀ of 64-120 µg/mL. Ilicicolin C affects seed germination and root tip growth of lettuce .

HY-N9248

6-Hydroxywogonin	Flavonoids Microorganisms Flavones Source Classification	Others
6-Hydroxywogonin (compound 26) is a flavonoid compound .

HY-N19887

Periandrin I	Periandra mediterranea (Vell.) Taub. Triterpenes Structural Classification Leguminosae Terpenoids Plants Source Classification	Biochemical Assay Reagents
Periandrin I is a triterpenoid glycoside. Periandrin I can be isolated from the roots of Periandra dulcis. Periandrin I acts as a sweetener, with a sweetness intensity comparable to that of Periandrin II, Periandrin IV and Glycyrrhizin (HY-N0184) .

Species:	Human (1) E.coli (1)
Tag:	His (2)
Source:	HEK293 (1) E. coli (1)

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HY-P70258

	Beta-glucuronidase/GUSB Protein, E.coli (N-His, solution) rE.coBeta-glucuronidase/GUSB, His; Beta-glucuronidase; uidA; GUS	E.coli	E. coli
	The beta-glucuronidase/GUSB protein displays activity with PNPG and 4-methylumbelliferyl-glucuronide. It scavenges glucuronate from various xenobiotic and endobiotic glucuronides in the GI tract, utilizing diverse carbon sources. As part of the GI microbiome, it can reactivate glucuronide drug conjugates, potentially harming the GI tract. Beta-glucuronidase/GUSB Protein, E.coli (N-His, solution) is the recombinant E. coli-derived Beta-glucuronidase/GUSB protein, expressed by E. coli , with N-6*His labeled tag.

HY-P705499

	Beta-glucuronidase/GUSB Protein, Human (HEK293, His) Beta-glucuronidase; GUSB; Beta-G1; BG; MPS7	Human	HEK293

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HY-137522S

Zidovudine O-β-D-glucuronide-d3 sodium

Zidovudine O-β-D-glucuronide-d₃ sodium (3'-Azido-3'-deoxythymidine β-D-glucuronide-d₃ sodium) is a deuterium labeled Zidovudine O-β-D-glucuronide sodium (HY-137522). Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

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HY-P83108

	beta Glucuronidase Antibody (YA2853) GUSB; Beta-glucuronidase; Beta-G1	WB, IHC-P, ICC/IF, FC	Human
	beta Glucuronidase Antibody (YA2853) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to beta Glucuronidase.

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HY-137522

Zidovudine O-β-D-glucuronide sodium 3'-Azido-3'-deoxythymidine β-D-glucuronide sodium		Azide
Zidovudine O-β-D-glucuronide (3'-Azido-3'-deoxythymidine β-D-glucuronide) sodium is the glucuronide conjugate and metabolite of Zidovudine (HY-17413), which can be used to detect UGT2B7 activity. As a substrate, Zidovudine O-β-D-glucuronide sodium undergoes deconjugation via hydrolysis by immobilized β-glucuronidase to produce Zidovudine .

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