2. Anti-infection
  3. Bacterial
  4. UNC10201652

UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes.

For research use only. We do not sell to patients.

UNC10201652 Chemical Structure

UNC10201652 Chemical Structure

CAS No. : 372495-52-8

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UNC10201652 Related Antibodies

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Description

UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2].

IC50 & Target

IC50: 0.117 μM (E. coli GUS)[1]
EC50: 74±7 nM (E. coli)[1]
In Vitro

UNC10201652 exhibits potently inhibitory activity against wild type E. coli with an EC50 of 74±7 nM[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UNC10201652 Related Antibodies
Molecular Weight

411.52

Formula

C20H25N7OS
CAS No.
Appearance

Liquid

Color

White to off-white

SMILES

C1(N=NN=C2N3CCNCC3)=C2SC4=C1C(CCCC5)=C5C(N6CCOCC6)=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 13.3 mg/mL (32.32 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4300 mL 12.1501 mL 24.3002 mL
5 mM 0.4860 mL 2.4300 mL 4.8600 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥98.0%

COA (256 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4300 mL 12.1501 mL 24.3002 mL 60.7504 mL
5 mM 0.4860 mL 2.4300 mL 4.8600 mL 12.1501 mL
10 mM 0.2430 mL 1.2150 mL 2.4300 mL 6.0750 mL
15 mM 0.1620 mL 0.8100 mL 1.6200 mL 4.0500 mL
20 mM 0.1215 mL 0.6075 mL 1.2150 mL 3.0375 mL
25 mM 0.0972 mL 0.4860 mL 0.9720 mL 2.4300 mL
30 mM 0.0810 mL 0.4050 mL 0.8100 mL 2.0250 mL
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UNC10201652 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UNC10201652372495-52-8UNC 10201652UNC-10201652BacterialE. coligut bacterialβ-glucuronidaseGUSSN-38 glucuronidegut microbiotaInhibitorinhibitorinhibit

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