372495-52-8
Chemical Structure
UNC10201652
- CAS No.: 372495-52-8
- Formula:C20H25N7OS
- Molecular Weight:411.52
IUPAC Name: 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine
InChIKey: ZPVQONCMKZBGTB-UHFFFAOYSA-N
SMILES: C1(N=NN=C2N3CCNCC3)=C2SC4=C1C(CCCC5)=C5C(N6CCOCC6)=N4
Biological Activity: UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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UNC10201652 | 99.38% | UNC10201652 is a potent Loop 1 (L1)-specific gut bacterial β-glucuronidase (GUSs) inhibitor with an IC50 value of 0.117 μM for E. coli GUS. UNC10201652 can block SN-38 glucuronide (HY-126373) processing only in individuals whose fecal gut microbiota is highly abundant in L1 GUS enzymes. | ||||||||||||||||||||
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- [1]. Jariwala PB, et al. Discovering the Microbial Enzymes Driving Drug Toxicity with Activity-Based Protein Profiling. ACS Chem Biol. 2020 Jan 17;15(1):217-225. [Content Brief]
- [2]. Pellock SJ, et al. Gut Microbial β-Glucuronidase Inhibition via Catalytic Cycle Interception. ACS Cent Sci. 2018 Jul 25;4(7):868-879. [Content Brief]
Keywords
