2. Metabolic Enzyme/Protease
  3. β-glucuronidase Glycosidase Phosphatase
  4. CH-123

CH-123 is an orally active lipid-lowering agent. CH-123 inhibits the elevated activities of β-glucuronidase, β-galactosidase, N-acetyl-β-glucosaminidase and acid phosphatase in aortic smooth muscle cells and hepatocytes. CH-123 reduces serum total lipid and cholesterol levels, as well as intracellular cholesterol content in aortic smooth muscle cells. CH-123 significantly inhibits lysosomal enzyme activity. CH-123 can be used in the research of atherosclerosis.

For research use only. We do not sell to patients.

CH-123

CH-123 Chemical Structure

CAS No. : 64405-40-9

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

CH-123 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

CH-123 is an orally active lipid-lowering agent. CH-123 inhibits the elevated activities of β-glucuronidase, β-galactosidase, N-acetyl-β-glucosaminidase and acid phosphatase in aortic smooth muscle cells and hepatocytes. CH-123 reduces serum total lipid and cholesterol levels, as well as intracellular cholesterol content in aortic smooth muscle cells. CH-123 significantly inhibits lysosomal enzyme activity. CH-123 can be used in the research of atherosclerosis[1].

In Vivo

CH-123 (50 mg/kg; p.o.; daily; 28 days) suppresses elevated lysosomal marker enzyme activities in aortic and liver cells of atherosclerotic rabbits to near-control levels, reduces serum total lipids and cholesterol by ~30% and ~29% respectively, and lowers aortic smooth muscle cell cholesterol content by 28%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain (5 animals per group; atherosclerosis induced by 2% cholesterol diet for 4 weeks)[1]
Dosage: 50 mg/kg
Administration: p.o.; daily; 28 days
Result: Reduced serum total lipids by ~30% (from 2452.72 mg/100 mL to 1715.90 mg/100 mL).
Reduced serum cholesterol by ~29% (from 801.75 mg/100 mL to 572.27 mg/100 mL).
Left serum triglycerides near cholesterol-fed levels (147.72 mg/100 mL vs. 150.52 mg/100 mL).
Reduced aortic smooth muscle cell cholesterol content by 28% (from 570 μg/mg protein to 412 μg/mg protein).
Restored aortic β-glucuronidase activity to 1.41 munit/mg protein (181% of control), β-galactosidase activity to 1.73 munit/mg protein (244% of control), N-acetyl-β-glucosaminidase activity to 1.39 munit/mg protein (151% of control), and acid phosphatase activity to 11.19 munit/mg protein (189% of control), with no significant difference from control levels.
Restored liver β-glucuronidase activity to 21.17 munit/mg protein (168% of control), β-galactosidase activity to 1.91 munit/mg protein (108% of control), N-acetyl-β-glucosaminidase activity to 1.48 munit/mg protein (140% of control), and acid phosphatase activity to 15.54 munit/mg protein (120% of control), with no significant difference from control levels.
Reduced β-glucuronidase activity in the low-density (1.09 g/cm3) lysosomal fraction of aorta, which was selectively elevated in untreated atherosclerotic rabbits.
Molecular Weight

294.30

Formula

C14H18N2O5
CAS No.
SMILES

O=C(C1=CN=C2N(C(CCC2CC(O)=O)C)C1=O)OCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

CH-123 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CH-12364405-40-9CH123CH 123β-glucuronidaseGlycosidasePhosphataseGUSBacid phosphataseratsN-acetyl-β-glucosaminidaseaortic smooth muscle cellsarterial plaqueglycosaminoglycan metabolismβ-galactosidaseliver cellsatherosclerosisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
CH-123
Cat. No.:
HY-182616
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.