Beta-glucuronidase (bovine liver)
Based on 1 publication(s) in Google Scholar
Beta-glucuronidase (bovine liver) is a glycoside hydrolase that hydrolyzes β-glucuronic acid and sulfate esters in urine and other biological fluids, thereby releasing β-glucuronides. Beta-glucuronidase (bovine liver) cannot effectively hydrolyze Estriol glucuronide. Beta-glucuronidase (bovine liver) can be used in studies related to systemic gangliosidosis.
For research use only. We do not sell to patients.
- CAS No.: 9001-45-0
- Molecular Weight:290 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Beta-glucuronidase (bovine liver)
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Biological Activity
Beta-glucuronidase (bovine liver) is taken up by type I generalized gangliosidosis fibroblasts via a saturable, receptor-mediated endocytosis system, which is distinct from the mannose-6-phosphate recognition system utilized by bovine testis β-galactosidase; at a limiting concentration of 200 U/mL, its uptake rate is 90-fold that of horseradish peroxidase[1].
In the presence of sodium sulfate, Beta-glucuronidase (bovine liver) efficiently hydrolyzes the glucuronides of androsterone, etiocholanolone, pregnanediol, and 17-hydroxycorticosteroids in natural urine (hydrolysis rate ≥93.5%), but exhibits poor hydrolytic activity toward estriol glucuronide (hydrolysis rate 41.8%)[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
3.2.1.31
≥ 1000000 u/g soild
One unit is defined as the amount of enzyme that liberate 1.0 μg of phenolphthalein from phenolphthalein glucuronide per hr at 37°C at pH 5.0 (30 min assay).
Chemical Information
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CAS No. 9001-45-0
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Appearance Solid
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Molecular Weight 290 kDa
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Color Off-white to light brown
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SMILES
[Beta-glucuronidase (bovine liver)]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
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Data Sheet (268 KB)
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SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
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Handling Instructions (2659 KB)
References
[1]. Hieber V, et al. Selective noncompetitive assimilation of bovine testicular beta-galactosidase and bovine liver beta-glucuronidase by generalized gangliosidosis fibroblasts. The Journal of clinical investigation. 1980 Apr;65(4):879-84. [Content Brief]
[2]. Graef V, et al. Hydrolysis of steroid glucuronides with beta-glucuronidase preparations from bovine liver, Helix pomatia, and E. coli. Clinical chemistry. 1977 Mar;23(3):532-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Beta-glucuronidase (bovine liver) Related Classifications
HY-P2803A Related Classifications
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- Beta-glucuronidase (bovine liver)
- 9001-45-0
- β-glucuronidase
- horseradish peroxidase
- Type I generalized gangliosidosis fibroblasts
- sodium sulfate
- p-nitrophenyl glucuronide
- β-glucuronidase-deficient fibroblasts
- phosphomannosyl recognition system
- generalized gangliosidosis fibroblasts
- bovine testicular β-galactosidase
- glucuronide substrates
- Inhibitor
- inhibitor
- inhibit