Search Result
Results for "
3-hydroxy
" in MedChemExpress (MCE) Product Catalog:
5
Biochemical Assay Reagents
26
Isotope-Labeled Compounds
Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-133111
-
|
5-HT Receptor
|
Neurological Disease
|
3-Hydroxy agomelatine is a metabolite of Agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM .
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-
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- HY-124245
-
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Others
|
Others
|
3-Hydroxy desloratidine is a metabolite of Desloratidine .
|
-
-
- HY-143976S
-
-
-
- HY-141696S
-
-
-
- HY-124245S
-
-
-
- HY-132427S
-
-
-
- HY-133111S
-
|
5-HT Receptor
|
Neurological Disease
|
3-Hydroxy agomelatine-d3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM[1].
|
-
-
- HY-144950S
-
|
Isotope-Labeled Compounds
|
Others
|
3-Hydroxy benzopyrene-d11is the deuterium labeled3-Hydroxy benzopyrene(HY-144950) . 3-Hydroxy benzopyrene is a metabolite of Benzopyrene (HY-107377) .
|
-
-
- HY-124245S1
-
-
-
- HY-108263
-
CGP52421
|
FLT3
|
Cancer
|
3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412 .
|
-
-
- HY-108263S
-
CGP52421-d5
|
Isotope-Labeled Compounds
FLT3
|
Cancer
|
3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].
|
-
-
- HY-W342499
-
Methyl 3-hydroxytetradecanoate; 3-OH PAME; Methyl 3-hydroxymyristate
|
Others
|
Metabolic Disease
|
3-Hydroxy myristic acid methyl ester (Methyl 3-hydroxytetradecanoate) is the quorum-sensing signal molecule (quormone), which regulates the virulence of Ralstonia solanacearum .
|
-
-
- HY-141639
-
-
-
- HY-N9241
-
|
Others
|
Neurological Disease
|
3-Hydroxy-7-methoxyflavone (compound 1) is a
flavonoid. 3-Hydroxy-7-methoxyflavone is isolated from natural Salvia
elegans. 3-Hydroxy-7-methoxyflavone has anti-anxiety effect
.
|
-
-
- HY-W008188
-
-
-
- HY-W041195S
-
|
Isotope-Labeled Compounds
|
Others
|
3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
|
-
-
- HY-W002339
-
|
DNA/RNA Synthesis
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Others
|
3-Hydroxy-2-methylpyridine, isolated from alkaline extracts of cocoa, is used in the synthesis of pyrimidine .
|
-
-
- HY-W143303S
-
-
-
- HY-69341
-
|
Biochemical Assay Reagents
|
Others
|
3-Hydroxy-4-nitrobenzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
-
- HY-N8994
-
|
Others
|
Cancer
|
3-Hydroxy-4',5-dimethoxystilbene is a natural compound found in stem bark of Morus nigra L .
|
-
-
- HY-N6864
-
3-hydroxy-4-methoxybenzoic acid
|
Others
|
Inflammation/Immunology
|
Isovanillic acid (3-Hydroxy-4-methoxybenzoic acid) is a phenolic acid isolated from isolated from Scrophularia ningpoensis, with Anti-inflammatory activity .
|
-
-
- HY-N3432
-
|
Others
|
Others
|
3-Hydroxy-5,7,4′-trimethoxyflavone is a flavonol can be isolated from Cucubalus baccifer (L.) .
|
-
-
- HY-139951S
-
|
Isotope-Labeled Compounds
|
Others
|
3-Hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium) is the deuterium labeled 3-Hydroxy-3-methylglutaryl-Coenzyme A ammonium[1].
|
-
-
- HY-N11526
-
|
Others
|
Inflammation/Immunology
|
3-Hydroxy-2-(palmitoyloxy)propyl stearat is a non-volatile compound. 3-Hydroxy-2-(palmitoyloxy)propyl stearat can be isolated from less polar fractions of the brown macroalga Fucus virsoides J. Agardh. This part of the substance has a good ability to scavenge free radicals and has a protective effect on the oxidative stress induced by hydrogen peroxide in zebrafish embryos .
|
-
-
- HY-B0906
-
3-hydroxy-p-butyrophenetidide
|
Others
|
Others
|
Bucetin (3-Hydroxy-p-butyrophenetidide) is an analgesic and antipyretic compound.
|
-
-
- HY-W002484
-
Acetoisovanillone; Isoacetovanillone
|
Others
|
Inflammation/Immunology
|
3-Hydroxy-4-methoxyacetophenone(Acetoisovanillone; Isoacetovanillone) is an active compound isolated from P. spinosa. Isoacetovanillone possesses anti-inflammatory activity and prevented injuries due to administration of acetic acid in the colon .
|
-
-
- HY-N9274
-
|
Others
|
Others
|
3-Hydroxy-3-(4-hydroxyphenyl)-lactic acid is a key metabolite in the P. roqueforti fermentation approach, with quantitative data of 10.2 ± 1.1 µM in Tyr 1 (presence of L-tyrosine) of .
|
-
-
- HY-W127823
-
3-hydroxy-2-(5-hydroxypentyl)-4H-1-benzopyran-4-one
|
Biochemical Assay Reagents
|
Others
|
3-Hydroxy-2-(5-hydroxypentyl)chromen-4-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
-
- HY-W002110
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3-hydroxy-4-methoxyphenylacetic acid; iso-HVA; Homoisovanillic acid
|
Endogenous Metabolite
|
Cancer
|
Isohomovanillic acid (3-Hydroxy-4-methoxyphenylacetic acid) is extracted from urine at pH 2 by ethyl acetate. Isohomovanillic acid is not found in appreciable values in many normal human urines .
|
-
-
- HY-G0004
-
-
-
- HY-135358
-
3-hydroxy-5-Keto Fluvastatin
|
HMG-CoA Reductase (HMGCR)
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Cardiovascular Disease
|
(Rac)-5-Keto Fluvastatin (3-Hydroxy-5-Keto Fluvastatin) is an impurity of Fluvastatin (XU 62320). Fluvastatin is a HMG-CoA reductase inhibitor with an IC50 of 8 nM .
|
-
-
- HY-N0761
-
3-hydroxy-4-methoxycinnamic acid
|
Adrenergic Receptor
Influenza Virus
|
Infection
Metabolic Disease
Endocrinology
|
Isoferulic acid (3-Hydroxy-4-methoxycinnamic acid) is a cinnamic acid derivative that has antidiabetic activity. Isoferulic acid binds to and activates α1-adrenergic receptors (IC50=1.4 µM) to enhance secretion of β-endorphin (EC50=52.2 nM) and increase glucose use. Isoferulic acid also has anti-influenza virus activities.
|
-
-
- HY-133112
-
3-hydroxy-7-desmethyl agomelatine
|
Melatonin Receptor
5-HT Receptor
|
Neurological Disease
|
7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine . Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist .
|
-
-
- HY-W013557
-
3-hydroxy-xanthen-9-one
|
Integrin
|
Inflammation/Immunology
|
3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one) is a xanthone compound, with . 3-Hydroxyxanthone inhibits NADPH-catalysed lipid peroxidation in human umbilical vein endothelial cells (HUVECs). 3-Hydroxyxanthone also inhibits TNF-alpha induced ICAM-1 expression .
|
-
-
- HY-113294S
-
3-hydroxy-DL-kynurenine-13C3,15N
|
Isotope-Labeled Compounds
|
Others
|
3-Hydroxykynurenine- 13C3, 15N (3-Hydroxy-DL-kynurenine- 13C3, 15N)is the 13C and 15N labeled3-Hydroxykynurenine(HY-113294) . 3-Hydroxykynurenine, a?metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .
|
-
-
- HY-I0637
-
-
-
- HY-B1189
-
-
-
- HY-113294
-
3-hydroxy-DL-kynurenine
|
Endogenous Metabolite
Apoptosis
|
Neurological Disease
|
3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .
|
-
-
- HY-W712674
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3-hydroxy-3-methylglutaryl-CoA
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Others
|
Metabolic Disease
|
HMG-CoA is a product generated by the hydration reaction of (E)-3-methylglutaconyl-CoA (MG-CoA) catalyzed by methylglutaconyl-CoA hydratase (MGCH) .
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-
-
- HY-N1836
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3-hydroxy-3-acetonyloxindole
|
|
|
3-Acetonyl-3-hydroxyoxindole (AHO) is a potent systemic acquired resistance (SAR) inducer in plants. 3-Acetonyl-3-hydroxyoxindole induces resistance in tobacco plants against infection with tobacco mosaic virus (TMV) and the fungal pathogen Erysiphe cichoracearum. 3-Acetonyl-3-hydroxyoxindole increases the level of pathogenesis-related gene 1 (PR-1) expression, salicylic acid (SA) accumulation and phenylalanine ammonia-lyase activity .
|
-
-
- HY-113294R
-
3-hydroxy-DL-kynurenine (Standard)
|
Endogenous Metabolite
Apoptosis
|
Neurological Disease
|
3-Hydroxykynurenine (Standard) is the analytical standard of 3-Hydroxykynurenine. This product is intended for research and analytical applications. 3-Hydroxykynurenine, a metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .
|
-
-
- HY-I0637S
-
3-hydroxy-4-methoxybenzaldehyde-d3
|
Isotope-Labeled Compounds
|
|
Isovanillin-d3 is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].
|
-
-
- HY-B1189S
-
Dicrotalic acid-d3; 3-hydroxy-3-methylglutaric acid-d3
|
Autophagy
HMG-CoA Reductase (HMGCR)
Endogenous Metabolite
|
Cardiovascular Disease
|
Meglutol-d3 is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
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-
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- HY-135335S
-
|
Drug Metabolite
|
Metabolic Disease
|
3'-Hydroxy Repaglinide-d5 is the deuterium labeled 3'-Hydroxy Repaglinide. 3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide[1].
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-
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- HY-135335
-
|
Drug Metabolite
|
Metabolic Disease
|
3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide. Repaglinide is a carbamoylmethyl benzoic acid (CMBA) derivative, which recently has become available for the treatment of type II diabetes .
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-
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- HY-N8531
-
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Others
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Others
|
4α-Methylcholesterol is a Cholesterol derivative. 4α-Methylcholesterol can oxidize 3-hydroxy steroid, with the apparent Km of 12.6 μM .
|
-
-
- HY-160755
-
-
-
- HY-W025101S
-
Ethyl 3-hydroxy-3-methylbutyrate-d6
|
Isotope-Labeled Compounds
|
Others
|
Ethyl 3-hydroxy-3-methylbutanoate-d6 is the deuterium labeled Ethyl 3-hydroxy-3-methylbutanoate[1].
|
-
-
- HY-N3287
-
|
Bacterial
|
Infection
|
Methyl 3-hydroxy-4,5-dimethoxybenzoate is a gallic acid derivant isolated from myricaria Laxiflora. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows obvious antimicrobial activities. Methyl 3-hydroxy-4,5-dimethoxybenzoate shows fairly active for oxidation resistance in the presence of H2O2 .
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-
-
- HY-136345
-
|
Drug Metabolite
|
Others
|
(Rac)-3′-Hydroxy simvastatin is a metabolite of Simvastatin. Simvastatin is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM .
|
-
- HY-108263B
-
(R)-CGP52421
|
FLT3
Drug Metabolite
|
Cancer
|
(R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
|
-
- HY-142098
-
-
- HY-113322S
-
-
- HY-108263A
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(S)-CGP52421
|
FLT3
Drug Metabolite
|
Cancer
|
(S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et). (S)-3-Hydroxy Midostaurin is a minor metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (S)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) .
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-
- HY-W012873
-
-
- HY-144343S
-
-
- HY-124352
-
|
Bacterial
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Others
|
2-nonyl-3-hydroxy-4-Quinolone (C9-PQS) is a quinolone compound produced by P. aeruginosa and other related bacterias. 2-nonyl-3-hydroxy-4-Quinolone is a quorum sensing (QS) signal molecule that controls the expression of many virulence genes as a function of cell population density .
|
-
- HY-W008467
-
-
- HY-114294A
-
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Biochemical Assay Reagents
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Metabolic Disease
|
DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor .
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-
- HY-123672S
-
-
- HY-138026
-
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Others
|
Metabolic Disease
|
(3β)-3-Hydroxy-7-oxochol-5-en-24-oic acid is a bile acid, and is a metabolite of 7β-hydroxy cholesterol (HY-113341) .
|
-
- HY-144418S
-
-
- HY-N0761A
-
trans-3-hydroxy-4-methoxycinnamic acid
|
NO Synthase
Prostaglandin Receptor
|
Inflammation/Immunology
|
trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity .trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1) .
|
-
- HY-W010320
-
2-Ethyl-3-hydroxy-4H-pyran-4-one
|
Biochemical Assay Reagents
|
Others
|
Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one), an odor-active (OA) compound, is an important food additive and the main component of a type of incense added to food .
|
-
- HY-N10668
-
|
Others
|
Others
|
2-(3-Hydroxy-2-oxoindolin-3-yl)-acetic acid (compound 29) is a natural polyphenol compound found in hop bract .
|
-
- HY-N12155
-
|
Others
|
Inflammation/Immunology
Cancer
|
(2,4,6-Trichloro-3-hydroxy-5-methoxyphenyl)methyl β-D-glucopyranoside (Compound 1) is a chlorophenyl glycoside that can be isolated from Lilium regale. Lilium regale is used for research of lung ailments .
|
-
- HY-N10158
-
|
Others
|
Cancer
|
1,7-Bis(4-hydroxyphenyl)-3-hydroxy-1,3-heptadien-5-one (compound 39), a diarylheptanoid, exhibits antiproliferative activity towards human HT-1080 fibrosarcoma and murine colon 26-L5 carcinoma cells .
|
-
- HY-W010320S
-
2-Ethyl-3-hydroxy-4H-pyran-4-one-d5
|
Isotope-Labeled Compounds
|
Others
|
Ethyl maltol-d5 is the deuterium labeled Ethyl maltol. Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one), an odor-active (OA) compound, is an important food additive and the main component of a type of incense added to food[1][2].
|
-
- HY-N8114
-
|
Others
|
Others
|
2-Naphthalenecarboxylic acid, 4-(D-glucopyranosyloxy)-1-hydroxy-3-(3-hydroxy-3-methylbutyl)-, methyl ester (compound 3) is a natural product that can be isolated from the dried roots of Rubia cordifolia .
|
-
- HY-128736
-
-
- HY-15919
-
-
- HY-101873
-
-
- HY-103228
-
LY300168 hydrochloride
|
iGluR
|
Neurological Disease
|
GYKI 53655 (LY300168) hydrochloride is an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) antagonist.
|
-
- HY-15072
-
YM 872
|
iGluR
|
Metabolic Disease
|
Zonampanel (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor.
|
-
- HY-117581
-
6-Oxo Simvastatin; Iso-simvastatin-6-one
|
HMG-CoA Reductase (HMGCR)
|
Metabolic Disease
|
L-669,262, a potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, with an IC50 of 0.10 ng/mL for rat liver HMG-CoA .
|
-
- HY-135373
-
-
- HY-135375
-
|
Drug Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids .
|
-
- HY-101873R
-
|
HMG-CoA Reductase (HMGCR)
|
Metabolic Disease
Inflammation/Immunology
|
Atorvastatin lactone (Standard) is the analytical standard of Atorvastatin lactone. This product is intended for research and analytical applications. Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor .
|
-
- HY-101873S
-
-
- HY-113410
-
|
Endogenous Metabolite
|
Metabolic Disease
|
3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH) .
|
-
- HY-W002620
-
2-Ethyl-3-hydroxy-6-methylpyridine
|
Biochemical Assay Reagents
|
Others
|
Emoxypine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
|
-
- HY-133052
-
|
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-100793
-
SR12813
3 Publications Verification
GW 485801
|
HMG-CoA Reductase (HMGCR)
Autophagy
|
Metabolic Disease
|
SR12813 (GW 485801) is an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, with an IC50 value of 0.85 μM . SR12813 is also an efficient agonist of human pregnane X receptor (hPXR). SR12813 can strongly bind to hPXR but not to mouse PXR (mPXR) [3].
|
-
- HY-141244
-
|
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-141212
-
Pentafluorophenyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate
|
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096069
-
|
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG3-MS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-W096154
-
|
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-130672
-
|
PROTAC Linkers
|
Cancer
|
Hydroxy-PEG3-NHS is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs .
|
-
- HY-17379
-
CI-981; Atorvastatin hemicalcium
|
HMG-CoA Reductase (HMGCR)
Autophagy
Ferroptosis
|
Metabolic Disease
Inflammation/Immunology
|
Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively [3].
|
-
- HY-15079
-
GYKI-53773; LY-300164
|
iGluR
Apoptosis
|
Neurological Disease
Cancer
|
Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity . Talampanel (IVAX) has neuroprotective effects in rodent stroke models . Talampanel attenuates caspase-3 dependent apoptosis in mouse brain .
|
-
- HY-113410S
-
|
Endogenous Metabolite
|
Metabolic Disease
|
3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
|
-
- HY-W002620A
-
-
- HY-122742
-
|
iGluR
|
Neurological Disease
|
HBT1 is a potent α-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptor (AMPA-R) potentiator. HBT1 bonds with S518 in the ligand-binding domain (LBD) of AMPA-R in a glutamate-dependent manner. HBT1 did not show remarkable bell-shaped response in brain-derived neurotrophic factor (BDNF) production in primary neurons .
|
-
- HY-151822
-
|
ADC Linker
|
Others
|
Hydroxy-PEG3-DBCO is a click chemistry reagent containing an azide group. Hydroxy-PEG3-DBCO is a PEG linker containing a DBCO moiety and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .
|
-
- HY-17379R
-
CI-981 (Standard); Atorvastatin hemicalcium (Standard)
|
HMG-CoA Reductase (HMGCR)
Autophagy
Ferroptosis
|
Metabolic Disease
Inflammation/Immunology
Cancer
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Atorvastatin (hemicalcium salt) (Standard) is the analytical standard of Atorvastatin (hemicalcium salt). This product is intended for research and analytical applications. Atorvastatin hemicalcium salt (CI-981) is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids. Atorvastatin hemicalcium salt inhibits human SV-SMC proliferation and invasion with IC50s of 0.39 μM and 2.39 μM, respectively [3].
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- HY-146628S
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- HY-N0761AS
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Prostaglandin Receptor
NO Synthase
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Inflammation/Immunology
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trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].
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- HY-19671
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SR-45023A; SR 9223i; SK&F-99085
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Apoptosis
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Cancer
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Apomine (SR-45023A) is an antineoplastic agent that inhibits the mevalonate/isoprenoid pathway in cholesterol synthesis. It can accelerate the degradation of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR). Apomine can also inhibit the growth of various types of cancer cells, including lung cancer, colon cancer, breast cancer, and skin cancer. In addition, Apomine is able to induce apoptosis in tumor cell lines derived from leukemia, colon cancer, liver cancer, ovarian cancer, and breast cancer .
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- HY-130546
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ADC Linker
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Cancer
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Hydroxy-PEG3-SS-PEG3-alcohol is also a cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
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- HY-W012293
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Nucleoside Antimetabolite/Analog
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Others
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4-Amino-1-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (3'-Deoxycytidine) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .
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- HY-W002620S
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- HY-112540
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Endogenous Metabolite
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Neurological Disease
Metabolic Disease
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Acetoacetic acid is an endogenous metabolite present in Cerebrospinal_Fluid and Blood that can be used for the research of Meningitis, Pregnancy, 3 Hydroxy 3 Methylglutaryl CoA Lyase Deficiency, Preeclampsia/Eclampsia, Diabetes Mellitus Type 2, Glucose Transporter Type 1 Deficiency Syndrome and Succinyl CoA:3 Oxoacid CoA Transferase Deficiency [3] .
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- HY-N10917
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Cholinesterase (ChE)
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Infection
Cancer
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Xanthohumol I, a chalkone, is a derivative of Xanthohumol (HY-N1067). Xanthohumol is a Cholinesterase (ChE) inhibitor, which inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) wih IC50s of 71.34 μM and 32.67 μM, respectively. The hydroxy compound of Xanthohumol (3-hydroxy-xanthohumol), also shoes inhibitory effect on AChE and BChE with IC50s of 51.25 μM and 63.07 μM .
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Cat. No. |
Product Name |
Type |
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- HY-69341
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Biochemical Assay Reagents
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3-Hydroxy-4-nitrobenzoic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-15919
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- HY-W127823
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3-hydroxy-2-(5-hydroxypentyl)-4H-1-benzopyran-4-one
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Biochemical Assay Reagents
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3-Hydroxy-2-(5-hydroxypentyl)chromen-4-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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- HY-114294A
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Biochemical Assay Reagents
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DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) disodium is a disodium salt compound of HMG-CoA, is a intermediate of terpenes and ketone bodies. DL-3-Hydroxy-3-methylglutaryl coenzyme A disodium also involves in ester metabolism in vivo, as a precursor for cholesterol synthesis, and regulates cholesterol synthesis by coupling LDL receptor .
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- HY-W002620
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2-Ethyl-3-hydroxy-6-methylpyridine
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Biochemical Assay Reagents
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Emoxypine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
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Cat. No. |
Product Name |
Target |
Research Area |
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- HY-W008467
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- HY-W012873
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- HY-117141
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AGABA
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Peptides
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Others
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N-Arachidonoyl-3-hydroxy-γ-aminobutyric acid is an arachidonoyl amino acid .
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- HY-P4755
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Peptides
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Others
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N-((RS)-2-Hydroxy-propyl)-Val-Leu-anilide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
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- HY-158104
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Peptides
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Others
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LPPM-8 is a ligand of Med25 and an inhibitor of Med25 protein-protein interactions (PPIs). LPPM-8 engages Med25 through interaction with the H2 face of its Activator Interaction Domain and stabilizes full-length protein in the cellular proteome. LPPM-8 is an orthosteric inhibitor of H2-binding transcriptional activators (such as ATF6a). LPPM-8 can be used for studying Med25 and Mediator complex biology .
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- HY-125357
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Peptides
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Metabolic Disease
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Ternatin (compound 2) is a cyclic heptapeptides that can be isolated from mushroom Coliorus versicolor. Ternatin inhibits fat-accumulation with an IC50 of 0.027 μM in 3T3-L1 adipocytes .
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Product Name |
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* This product has been "discontinued".
Optimized version of product available:
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Cat. No. |
Product Name |
Chemical Structure |
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- HY-133111S
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3-Hydroxy agomelatine-d3 is a deuterium labeled 3-Hydroxy agomelatine. 3-Hydroxy agomelatine is a 5-HT2C receptor antagonist with an IC50 of 3.2 μM and a Ki of 1.8 μM[1].
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- HY-143976S
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3-Hydroxy imiquimod-d4 is the deuterium labeled 3-Hydroxy imiquimod.
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- HY-141696S
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3-Hydroxy Mepivacaine-d3 is the deuterium labeled 3-Hydroxy Mepivacaine[1].
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- HY-124245S
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3-Hydroxy desloratadine-d4 is the deuterium labeled 3-Hydroxy desloratadine[1].
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- HY-132427S
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3-Hydroxy Lidocaine-d5 is the deuterium labeled 3-Hydroxy Lidocaine[1].
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- HY-144950S
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3-Hydroxy benzopyrene-d11is the deuterium labeled3-Hydroxy benzopyrene(HY-144950) . 3-Hydroxy benzopyrene is a metabolite of Benzopyrene (HY-107377) .
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- HY-124245S1
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3-Hydroxy desloratadine-d4 (hydrobromide) is the deuterium labeled 3-Hydroxy desloratidine hydrobromide[1].
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- HY-108263S
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3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].
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- HY-W041195S
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3-Hydroxy-3-methylhexanoic acid-d5 is the deuterium labeled 3-Hydroxy-3-methylhexanoic acid (HY-W041195). 3-Hydroxy-3-methylhexanoic acid is a fatty acid that is one of the metabolic products of leukocytes .
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- HY-W143303S
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3-Hydroxy-3-methylvaleric acid-d5 is the deuterium labeled 3-Hydroxy-3-methylvaleric Acid[1].
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- HY-139951S
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3-Hydroxy-3-methylglutaryl-Coenzyme A-d3 (ammonium) is the deuterium labeled 3-Hydroxy-3-methylglutaryl-Coenzyme A ammonium[1].
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- HY-113294S
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3-Hydroxykynurenine- 13C3, 15N (3-Hydroxy-DL-kynurenine- 13C3, 15N)is the 13C and 15N labeled3-Hydroxykynurenine(HY-113294) . 3-Hydroxykynurenine, a?metabolite of tryptophan, is a potential endogenous neurotoxin whose increased levels have been described in several neurodegenerative disorders. 3-Hydroxykynurenine induces neuronal apoptosis .
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- HY-I0637S
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Isovanillin-d3 is the deuterium labeled Isovanillin[1]. Isovanillin is an aldehyde oxidase inhibitor[2]. Antispasmodic activities[3]. Antidiarrheal activities[4].
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- HY-B1189S
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Meglutol-d3 is the deuterium labeled Meglutol[1]. Meglutol is an antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids, and inhibits the activity of hydroxymethylglutarryl CoA reductases, which is the rate limiting enzyme in the biosynthesis of cholesterol.
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- HY-135335S
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3'-Hydroxy Repaglinide-d5 is the deuterium labeled 3'-Hydroxy Repaglinide. 3'-Hydroxy Repaglinide is a main CYP2C8 metabolite of Repaglinide[1].
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- HY-W025101S
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Ethyl 3-hydroxy-3-methylbutanoate-d6 is the deuterium labeled Ethyl 3-hydroxy-3-methylbutanoate[1].
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- HY-113322S
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(3S)-3-Hydroxy quinidine-vinyl-d3 is the deuterium labeled (3S)-3-Hydroxy quinidine-vinyl[1].
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- HY-144343S
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(Rac)-cis-3-hydroxy glyburide- 13C,d3 is a 13C-labeled and deuterium labeled (Rac)-cis-3-hydroxy glyburide[1].
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- HY-123672S
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Lovastatin-d3 hydroxy acid (sodium) is the deuterium labeled Lovastatin hydroxy acid sodium. Lovastatin hydroxy acid sodium (Mevinolinic acid sodium) is a highly potent inhibitor of HMG-CoA reductase with a Ki of 0.6 nM[1].
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- HY-144418S
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DL-2-Amino-3-(hydroxy-amino)propionic acid- 15N is a 15N-labeled DL-2-Amino-3-(hydroxy-amino)propionic acid[1].
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- HY-W010320S
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Ethyl maltol-d5 is the deuterium labeled Ethyl maltol. Ethyl maltol (2-Ethyl-3-hydroxy-4H-pyran-4-one), an odor-active (OA) compound, is an important food additive and the main component of a type of incense added to food[1][2].
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- HY-101873S
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Atorvastatin lactone-d5 is a deuterated form of Atorvastatin lactone (HY-101873). Atorvastatin lactone is a proagent form of atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor[1].
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- HY-113410S
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3-Methylglutaric acid-d4 is the deuterium labeled 3-Methylglutaric acid[1]. 3-Methylglutaric acid, a leucine metabolite, is a conspicuous C6 dicarboxylic organic acid classically associated with two distinct leucine pathway enzyme deficiencies, 3-hydroxy-3-methylglutaryl CoA lyase (HMGCL) and 3-methylglutaconyl CoA hydratase (AUH)[2][3].
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- HY-146628S
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5-Hydroxy-L-tryptophan-4,6,7-d3 is the deuterium labeled 5-Hydroxy-L-tryptophan-4,6,7[1].
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- HY-N0761AS
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trans-Isoferulic acid-d3 is the deuterium labeled trans-Isoferulic acid[1]. trans-Isoferulic acid (trans-3-Hydroxy-4-methoxycinnamic acid) is an aromatic acid isolated from the roots of Clematis florida var. plena. trans-Isoferulic acid exhibits anti-inflammatory activity[2].trans-isoferulic acid suppresses NO and PGE2 production through the induction of Nrf2-dependent heme oxygenase-1 (HO-1)[3].
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- HY-W002620S
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Emoxypine-d5 is deuterium labeled Emoxypine.
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Cat. No. |
Product Name |
Application |
Reactivity |
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- HY-P81197
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3 hydroxy 3 methylglutaryl CoA reductase; 3 hydroxy 3 methylglutaryl Coenzyme A reductase; 3 hydroxymethylglutaryl CoA reductase; 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; 3H3M; HMDH_HUMAN; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl CoA reductase; LDLCQ3; MGC103269; Red.
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ELISA; IHC-P; IHC-F; Flow-Cyt; IF
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Human, Mouse, Rat(predicted: Dog, Pig, Cow, Rabbit) |
HMGCR Antibody is an unconjugated, approximately 97 kDa, rabbit-derived, anti-HMGCR polyclonal antibody. HMGCR Antibody can be used for: ELISA, IHC-P, IHC-F, Flow-Cyt, IF expriments in human, mouse, rat, and predicted: dog, pig, cow, rabbit background without labeling.
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- HY-P83598
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HSD17B10; ERAB; HADH2; MRPP2; SCHAD; XH98G2; 3-hydroxyacyl-CoA dehydrogenase type-2; 17-beta-hydroxysteroid dehydrogenase 10; 17-beta-HSD 10; 3-hydroxy-2-methylbutyryl-CoA dehydrogenase; 3-hydroxyacyl-CoA dehydrogenase type II; Endoplasmic
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WB, IHC-P, ICC/IF, FC
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Human, Mouse, Rat |
Cat. No. |
Product Name |
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Classification |
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- HY-151822
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DBCO
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Hydroxy-PEG3-DBCO is a click chemistry reagent containing an azide group. Hydroxy-PEG3-DBCO is a PEG linker containing a DBCO moiety and a terminal primary hydroxyl group. The hydroxyl can react with a variety of functional groups and the hydrophilic PEG spacer arm can provide better solubility to labeled molecules. DBCO is commonly used for copper-free Click Chemistry reactions. Reagent grade, for research use only .
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