3-Hydroxy-2-methylpyridine

Cat. No.: HY-W002339 Purity: 99.65%: Data Sheet
COA

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3-Hydroxy-2-methylpyridine is a pharmaceutical intermediate that can be used in the synthesis of pyrimidines. 3-Hydroxy-2-methylpyridine acts as a corrosion inhibitor, serving as a mixed-type corrosion inhibitor for carbon steel in HCl medium.

For research use only. We do not sell to patients.

3-Hydroxy-2-methylpyridine Chemical Structure

CAS No. : 1121-25-1

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	In-stock	Estimated Time of Arrival: December 31
100 g	In-stock	Estimated Time of Arrival: December 31
250 g	In-stock	Estimated Time of Arrival: December 31
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Other Forms of 3-Hydroxy-2-methylpyridine:

3-Hydroxy-2-methylpyridine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
PANC-1	IC₅₀	> 100 μM Compound: 4	Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay Cytotoxicity against human PANC1 cells after 72 hrs by WST8 assay	[PMID: 28495081]

In Vitro

3-Hydroxy-2-methylpyridine (10^-5-10^-2 M) acts as a mixed-type corrosion inhibitor for carbon steel in 1 M HCl. Its corrosion inhibition efficiency increases with rising concentration (reaching 91.1% at 10^-2 M and 303 K, 95.3% at 10^-2 M and 313 K, and 95.4% at 10^-2 M and 323 K), and shows a slight increase with elevated temperature across all tested concentrations^[2].
3-Hydroxy-2-methylpyridine (10^-5-10^-2 M) reduces the corrosion rate of carbon steel in 1 M HCl in a concentration-dependent manner; the corrosion inhibition efficiency measured by the weight loss method reaches 89.8% at 10^-2 M and 303 K, 92.4% at 10^-2 M and 313 K, and 94.1% at 10^-2 M and 323 K, and the obtained results are highly consistent with those from polarization measurements^[2].
The adsorption behavior of 3-Hydroxy-2-methylpyridine (10^-5-10^-2 M) on carbon steel in a 1 M HCl system shows concentration dependence^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

109.13

Formula

C₆H₇NO

CAS No.

1121-25-1

Appearance

Solid

Color

Off-white to light brown

SMILES

CC1=NC=CC=C1O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (916.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.1634 mL	45.8169 mL	91.6338 mL
5 mM	1.8327 mL	9.1634 mL	18.3268 mL
10 mM	0.9163 mL	4.5817 mL	9.1634 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (45.82 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 5 mg/mL (45.82 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (45.82 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.65%

Select Batch:

Data Sheet (275 KB) SDS (554 KB)

COA (251 KB) HNMR (115 KB) RP-HPLC (277 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Bromidge SM, et al. 1-[2-[(Heteroaryloxy)heteroaryl]carbamoyl]indolines: novel and selective 5-HT2C receptor inverse agonists with potential as antidepressant/anxiolytic agents. Bioorg Med Chem Lett. 2000 Aug 21;10(16):1863-6. [Content Brief]

[2]. A-Uqaly RA, et al.. Corrosion behavor of Carbon steel Iin HCL media and Inhibition by 3-Hydroxy-2-Methylpyridine. Intemational
Journal of Advance Scientific and Technical Research. 2015;3(5):181-90.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	9.1634 mL	45.8169 mL	91.6338 mL	229.0846 mL
	5 mM	1.8327 mL	9.1634 mL	18.3268 mL	45.8169 mL
	10 mM	0.9163 mL	4.5817 mL	9.1634 mL	22.9085 mL
	15 mM	0.6109 mL	3.0545 mL	6.1089 mL	15.2723 mL
	20 mM	0.4582 mL	2.2908 mL	4.5817 mL	11.4542 mL
	25 mM	0.3665 mL	1.8327 mL	3.6654 mL	9.1634 mL
	30 mM	0.3054 mL	1.5272 mL	3.0545 mL	7.6362 mL
	40 mM	0.2291 mL	1.1454 mL	2.2908 mL	5.7271 mL
	50 mM	0.1833 mL	0.9163 mL	1.8327 mL	4.5817 mL
	60 mM	0.1527 mL	0.7636 mL	1.5272 mL	3.8181 mL
	80 mM	0.1145 mL	0.5727 mL	1.1454 mL	2.8636 mL
	100 mM	0.0916 mL	0.4582 mL	0.9163 mL	2.2908 mL