1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Apoptosis
  2. iGluR
    Apoptosis
  3. Talampanel

Talampanel (Synonyms: GYKI-53773; LY-300164)

Cat. No.: HY-15079 Purity: 98.02%
Handling Instructions

Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain.

For research use only. We do not sell to patients.

Talampanel Chemical Structure

Talampanel Chemical Structure

CAS No. : 161832-65-1

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 106 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
50 mg USD 492 In-stock
Estimated Time of Arrival: December 31
100 mg USD 792 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity[1]. Talampanel (IVAX) has neuroprotective effects in rodent stroke models[2]. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain[2].

In Vivo

Talampanel (orally administration; 5 mg/kg; once a day; 2 weeks) reduces motoneuronal calcium in a mouse model of ALS, but its efficacy declines as the disease progresses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female mutant SOD1 Tg mice[1]
Dosage: 5 mg/kg
Administration: Orally administration; 5 mg/kg; once a day; 2 weeks
Result: Had a significant effect in reducing the calcium level only at the age of 12 weeks.
Clinical Trial
Molecular Weight

337.37

Formula

C₁₉H₁₉N₃O₃

CAS No.
SMILES

C[[email protected]@H]1CC2=C(C=C(OCO3)C3=C2)C(C4=CC=C(N)C=C4)=NN1C(C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (296.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9641 mL 14.8205 mL 29.6410 mL
5 mM 0.5928 mL 2.9641 mL 5.9282 mL
10 mM 0.2964 mL 1.4821 mL 2.9641 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.41 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.02%

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Keywords:

TalampanelGYKI-53773 LY-300164GYKI53773GYKI 53773LY300164LY 300164LY-300164iGluRApoptosisIonotropic glutamate receptorsInhibitorinhibitorinhibit

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Product Name:
Talampanel
Cat. No.:
HY-15079
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