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Results for "

DNA+Methyltransferase

" in MedChemExpress (MCE) Product Catalog:

By Targets:	DNA Methyltransferase (62) Aminopeptidase (1) AMPK (1) Antibiotic (3) Apoptosis (12) Autophagy (5) Bacterial (7) Biochemical Assay Reagents (1) Caspase (1) CD38 (1) Cholecystokinin Receptor (1) COX (5) CRFR (2) DNA/RNA Synthesis (3) Drug Derivative (1) Endogenous Metabolite (4) Farnesyl Transferase (1) Ferroportin (1) HDAC (4) Hedgehog (1) Histone Methyltransferase (2) Isotope-Labeled Compounds (8) Keap1-Nrf2 (1) MDM-2/p53 (1) Mitochondrial Metabolism (1) MMP (1) NF-κB (1) NO Synthase (5) Nucleoside Antimetabolite/Analog (54) Organoid (3) Parasite (1) PGE synthase (5) Phosphoramidites (9) Potassium Channel (4) PPAR (1) Reactive Oxygen Species (ROS) (6) Reference Standards (7) SARS-CoV (1) Vasopressin Receptor (1) Virus Protease (1)
By Research Areas:	Cancer (83) Cardiovascular Disease (7) Endocrinology (1) Infection (10) Inflammation/Immunology (11) Metabolic Disease (3) Neurological Disease (3)
Click Chemistry:	Azide (3)
Oligonucleotides:	Nucleoside Analogs (38) Aptamers (1) Cytosine (9) Phosphoramidites (9) Cytidine (38)

126

Inhibitors & Agonists

Screening Libraries

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

GMP Molecules

Targets Recommended: DNA Methyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0004

Decitabine Maximum Cited Publications 168 Publications Verification 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716	DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog	Cancer
Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a *DNA methyltransferase* inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap *DNA methyltransferase* to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-10586

5-Azacytidine 125+ Cited Publications Azacitidine; 5-AzaC; Ladakamycin	Organoid Nucleoside Antimetabolite/Analog DNA Methyltransferase Bacterial Autophagy Antibiotic	Infection Cancer
5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap *DNA methyltransferases* and contributes to reverse epigenetic changes . 5-Azacytidine induces cell autophagy .

HY-135146

GSK-3484862 20+ Cited Publications	DNA Methyltransferase	Cancer
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .

HY-13642

RG108 10+ Cited Publications N-Phthalyl-L-tryptophan	DNA Methyltransferase	Inflammation/Immunology Cancer
RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC₅₀=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences .

HY-13962

SGI-1027 15+ Cited Publications	DNA Methyltransferase Apoptosis	Cancer
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC₅₀s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.

HY-134124

*Glutathione ethyl* ester**	Reactive Oxygen Species (ROS)	Metabolic Disease
Glutathione ethyl ester is a cell-permeable GSH donor and provides an efficient supply of GSH to the oocyte. Glutathione ethyl ester shows positive effect on the in vitro production of embryos by enhancement of the antioxidative defense .

HY-15229

Guadecitabine sodium 10+ Cited Publications SGI-110 sodium; S-110 sodium	DNA Methyltransferase	Cancer
Guadecitabine sodium (SGI-110 sodium) is a second-generation *DNA methyltransferases* (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) .

HY-151136

DY-46-2 1 Publications Verification	DNA Methyltransferase	Cancer
DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC₅₀ value of 0.39 μM .

HY-B2194

γ-Oryzanol Maximum Cited Publications 8 Publications Verification	DNA Methyltransferase	Metabolic Disease Cancer
γ-Oryzanol is a potent *DNA methyltransferases* (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC₅₀=3.2 μM), DNMT3a (IC₅₀=22.3 μM).

HY-13420

Zebularine 5 Publications Verification NSC309132; 4-Deoxyuridine	DNA Methyltransferase Autophagy	Cancer
Zebularine (NSC309132; 4-Deoxyuridine) is a *DNA methyltransferase* inhibitor. Zebularine also inhibits cytidine deaminase with a K_i of 0.95 μM.

HY-13668

Lomeguatrib 5+ Cited Publications PaTrin-2	DNA Methyltransferase	Cancer
Lomeguatrib is a O ⁶-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC₅₀s of 9 nM in cell-free assay and ～6?nM in MCF-7 cells.

HY-101925

CM-272 3 Publications Verification	Histone Methyltransferase DNA Methyltransferase Apoptosis	Cancer
CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual *G9a/DNA methyltransferases* (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP with IC₅₀s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis**, inducing IFN-stimulated genes and immunogenic cell death .

HY-A0084A

Procainamide 5+ Cited Publications Procaine amide; SP 100	DNA Methyltransferase Potassium Channel	Cardiovascular Disease Cancer
Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research .

HY-A0084

Procainamide hydrochloride 5+ Cited Publications Procaine amide hydrochloride; SP 100 hydrochloride	DNA Methyltransferase Potassium Channel	Cancer
Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research .

HY-12746

DC-05 1 Publications Verification	DNA Methyltransferase	Cancer
DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 10.3 μM and 1.09 μM, respectively.

HY-15228

RX-3117 2 Publications Verification TV-1360; Fluorocyclopentenylcytosine	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis .

HY-116217

5-Fluoro-2'-deoxycytidine 3 Publications Verification FdCyd; NSC-48006	DNA Methyltransferase	Cancer
5-Fluoro-2'-deoxycytidine (FdCyd), a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective proagent of thymidylate synthase inhibitor 5-fluoro-2′-dUMP. 5-Fluoro-2'-deoxycytidine can induce cell cycle arrest in tumor cells through the DNA damage response, and it has anti-tumor activity .

HY-P1108A

Astressin 2B TFA 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B TFA is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-P1108

Astressin 2B 1 Publications Verification	CRFR	Neurological Disease Inflammation/Immunology
Astressin 2B is a blood-brain barrier-impermeable, highly selective CRFR2 antagonist (rCRFR2, IC₅₀=0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2, thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility, bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model, Astressin 2B mimics the phenotype of CRFR2-deficient mice, significantly exacerbating intestinal epithelial damage, edema, neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2 .

HY-12747

DC_517 2 Publications Verification	DNA Methyltransferase	Cancer
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 1.7 μM and 0.91 μM, respectively.

HY-A0004R

Decitabine (Standard) 5-Aza-2'-deoxycytidine (Standard); 5-AZA-CdR (Standard); NSC 127716 (Standard)	Reference Standards DNA Methyltransferase Apoptosis Nucleoside Antimetabolite/Analog	Cancer
Decitabine (Standard) is the analytical standard of Decitabine. This product is intended for research and analytical applications. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a *DNA methyltransferase* inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap *DNA methyltransferase* to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-139015

5-Aza-4'-thio-2'-deoxycytidine 5-Aza-T-dCyd; NTX-301	DNA Methyltransferase	Cancer
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects .

HY-10586R

5-Azacytidine (Standard) Azacitidine (Standard); 5-AzaC (Standard); Ladakamycin (Standard)	Organoid Reference Standards Nucleoside Antimetabolite/Analog DNA Methyltransferase Bacterial Autophagy Antibiotic	Infection Cancer
5-Azacytidine (Standard) is the analytical standard of 5-Azacytidine. This product is intended for research and analytical applications. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap *DNA methyltransferases* and contributes to reverse epigenetic changes . 5-Azacytidine induces cell autophagy .

HY-112551

2′,3′,5′-Triacetyl-5-azacytidine	DNA Methyltransferase	Cancer
2′,3′,5′-Triacetyl-5-azacytidine is an orally active proagent of 5-Azacytidine. 5-Azacytidine is an inhibitor of DNA methyltransferase .

HY-12310

RSC133	DNA Methyltransferase HDAC MDM-2/p53	Others Inflammation/Immunology
RSC133 is a dual inhibitor of DNA methyltransferase 1 and histone deacetylase 1 inhibitor. RSC133 promotes cell proliferation, up-regulates H₃K₉ histone acetylation, down-regulates p53, p21, p16/INK4A, and ablates pro-senescence phenotypes .

HY-135146A

(Rac)-GSK-3484862	DNA Methyltransferase	Cancer
(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity .

HY-13542

Guadecitabine SGI-110	DNA Methyltransferase	Cancer
Guadecitabine (SGI-110) is a second-generation *DNA methyltransferases* (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) .

HY-W578275

3′-O-Methylcytidine	Nucleoside Antimetabolite/Analog	Cancer
3′-O-Methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-119390

AA-CW236	DNA Methyltransferase	Cancer
AA-CW236 is a MGMT (O6-methylguanine DNA methyltransferase) inhibitor. AA-CW236 targets MGMT active site Cys145 for covalent modification .

HY-W115186

DMT-2'-OMe-Bz-C	Nucleoside Antimetabolite/Analog Phosphoramidites	Cancer
DMT-2'-OMe-Bz-C is a cytidine analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W130466

N4-Methylcytidine	Nucleoside Antimetabolite/Analog	Others Cancer
N4-Methylcytidine (Nsc518744) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-123346

SW155246	DNA Methyltransferase	Cancer
SW155246 is a *DNA methyltransferase* (DNMT1) selective inhibitor with IC₅₀s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases .

HY-W114787

N4-Benzoyl-2’-O-methylcytidine	Nucleoside Antimetabolite/Analog	Cancer
N4-Benzoyl-2’-O-methylcytidine is a natural cytidine nucleoside analog. Cytidine analogs have the mechanism of inhibiting DNA methyltransferase (such as Zebularine (HY-13420)) and have potential antimetabolite and antitumor activities .

HY-154414

2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite	Nucleoside Antimetabolite/Analog Phosphoramidites	Cancer
2’-Fluoro-2’-deoxy-ara-C(Bz)-3’-phosphoramidite is a cytidine analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-164496

KL-50	DNA/RNA Synthesis	Cancer
KL-50 is a selective toxin toward tumors that lack the DNA repair protein O ⁶-methylguanine-DNA-methyltransferase (MGMT), which reverses the formation of O ⁶-alkylguanine lesions. KL-50 activates DNA damage response pathways and cycle arrest in MGMT-cells, independent of mismatch repair (MMR). KL-50 is promising for research of brain tumors that lack the DNA repair protein MGMT .

HY-E70206

CpG Methyltransferase CpG	DNA Methyltransferase Biochemical Assay Reagents	Others Cancer
CpG Methyltransferase is a DNA methyltransferase. CpG Methyltransferase can methylate the C5 position on the base moiety of all cytosine nucleotides contained in unmethylated or hemimethylated double stranded DNA in a 5’-CpG-3’ context .

HY-104039

2'-Deoxy-5'-O-DMT-5-methylcytidine	Nucleoside Antimetabolite/Analog Phosphoramidites	Cancer
2'-Deoxy-5'-O-DMT-5-methylcytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-173002

MS9024	DNA Methyltransferase	Cancer
MS9024 is the degrader for DNA methyltransferase 1 that degrades DNMT1 in cell HCT116 through the ubiquitin-proteasome pathway with a DC₅₀ of 35 nM (DC₅₀ in MDA-MB-468 and H1299 is 254 nM and 101 nM). MS9024 also inhibits DNMT1 with an IC₅₀ of 0.43 μM .

HY-175594

DNMT2-IN-2	DNA Methyltransferase	Cancer
DNMT2-IN-2 is a selective DNA methyltransferase 2 (DNMT2) inhibitor with a K_D value of 3.04 μM. DNMT2-IN-2 targets to a cryptic allosteric binding site of DNMT2. DNMT2-IN-2 reduces m₅C levels in MOLM-13 tRNA and synergizes with Doxorubicin (HY-15142A) to impair cell viability. DNMT2-IN-2 can be used for cancer research, such as cervical cancer and leukemia .

HY-122427

Xylocytidine	Nucleoside Antimetabolite/Analog	Cancer
Xylocytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-154150

N-(1-Oxopropyl)cytidine	Nucleoside Antimetabolite/Analog	Cancer
N-(1-Oxopropyl)cytidine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-101904

2-Chloro-2'-deoxycytidine	Nucleoside Antimetabolite/Analog	Others
2-Chloro-2'-deoxycytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152822

5-Iodo-2’-O-methylcytidine	Nucleoside Antimetabolite/Analog	Others
5-Iodo-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152483

N4,N4-Dimethylarabinocytidine	Nucleoside Antimetabolite/Analog	Others
N4,N4-Dimethylarabinocytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-W128788A

2’-Deoxy-2’-fluoro-b-D-arabinocytidine hydrochloride	Nucleoside Antimetabolite/Analog	Others
2’-Deoxy-2’-fluoro-b-D-arabinocytidine(hydrochloride) is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-152763

2’-Deoxy-2’-fluoro-5-methylcytidine	Nucleoside Antimetabolite/Analog	Others
2’-Deoxy-2’-fluoro-5-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

HY-E70212

Hhal Methyltransferase Hhal	DNA Methyltransferase	Cancer
Hhal Methyltransferase (Hhal) is a *DNA methyltransferase* (recognition sequence: GCGC) .

HY-177807

DNMT1 aptamer sodium	DNA Methyltransferase	Cancer
DNMT1 aptamer sodium is a DNA aptamer for binding and inhibition of DNA methyltransferase 1 (DNMT1).

HY-149289

DNMT-IN-3	Parasite DNA Methyltransferase	Others
DNMT-IN-3 is an *DNA Methyltransferase* (DNMT) inhibitor, and plays an antimalarial role with IC₅₀ of 60 nM against Plasmodium falciparum (Plasmodium). DNMT-IN-3 can be used for malaria related research .

HY-152714

5-Formyl-2’-O-methylcytidine	Nucleoside Antimetabolite/Analog	Others
5-Formyl-2’-O-methylcytidine is a cytidine nucleoside analog. Cytidine analogs have a mechanism of inhibiting *DNA methyltransferases* (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W012078

*5-Methyl-2'-deoxycytidine* 3 Publications Verification 5-Methyldeoxycytidine	Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	DNA Methyltransferase Endogenous Metabolite
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-B2194

γ-Oryzanol Maximum Cited Publications 8 Publications Verification	Monophenols other families Classification of Application Fields Phenols Plants Disease Research Fields Steroids Source Classification Cancer	DNA Methyltransferase
γ-Oryzanol is a potent *DNA methyltransferases* (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC₅₀=3.2 μM), DNMT3a (IC₅₀=22.3 μM).

HY-A0248A

Polymyxin B1 1 Publications Verification	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial
Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-N11722

Panduratin A	Structural Classification Phenols Polyphenols Boesenbergia rotunda Plants Source Classification Zingiberaceae	Apoptosis NF-κB Keap1-Nrf2 AMPK Autophagy SARS-CoV DNA Methyltransferase
Panduratin A is an orally active natural compound with multiple pharmacological activities. By specifically inhibiting the NF-κB signaling pathway, Panduratin A exerts potent anti-inflammatory and antioxidant effects in intestinal and vascular inflammation models. Panduratin A exerts a definite protective effect against Colistin (HY-113678)-induced nephrotoxicity by alleviating oxidative stress, improving mitochondrial dysfunction and inhibiting cell apoptosis. Panduratin A activates autophagy via an AMPK-dependent pathway and exhibits anti-tuberculosis activity. Panduratin A exerts antiviral effects by inhibiting the methyltransferase (DNA Methyltransferase) of SARS-CoV-2 .

HY-A0248AS

Polymyxin B1-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-N2150

Psammaplin A	Structural Classification Classification of Application Fields Marine natural products Antibacterial Disease Research Other Antibiotics Infection Microorganisms Animals Antibiotics Phenols Polyphenols Sponge Anticancer Disease Research Fields Source Classification	HDAC DNA Methyltransferase DNA/RNA Synthesis Bacterial Aminopeptidase Farnesyl Transferase PPAR Apoptosis
Psammaplin A is a marine metabolite. Psammaplin A is a selective HDAC1 (IC₅₀: 45 nM), *DNA methyltransferases* (IC₅₀: 18.6 nM) and aminopeptidase N (APN) (IC₅₀: 18 μM) inhibitor. Psammaplin A also inhibits DNA topoisomerase and farnesyl protein transferase. Psammaplin A is a PPARγ activator and induces apoptosis. Psammaplin A has antitumor and anti-inflammatory activities. Psammaplin A has antibacterial activity against Gram-positive bacteria and inhibits DNA synthesis and DNA gyrase activity. Psammaplin A inhibits angiogenesis .

HY-W012078R

*5-Methyl-2'-deoxycytidine (Standard)* 1 Publications Verification 5-Methyldeoxycytidine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards DNA Methyltransferase Endogenous Metabolite
5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA	Structural Classification Microorganisms Antibiotics Antibacterial Disease Research Other Antibiotics Source Classification	Isotope-Labeled Compounds Bacterial
Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Cat. No.	Product Name	Chemical Structure

HY-W740027

5-Methyl-2'-deoxycytidine-d3

5-Methyl-2'-deoxycytidine-d₃ (5-Methyldeoxycytidine-d₃) is the deuterium labeled Methyl-2'-deoxycytidine (HY-W012078). 5-Methyl-2'-deoxycytidine (5mdC) is an endogenous substrate of DNA methyltransferases (such as mammalian 5-C-MTase) and binds to DNA dependent on the formation of DNA stem-loop structures. 5-Methyl-2'-deoxycytidine guides de novo DNA methylation by acting as a methylation mark and activates the methylation of adjacent CpG sites in single-stranded DNA through cis action. 5-Methyl-2'-deoxycytidine regulates DNA methylation patterns by recruiting methyltransferases to specific chromatin regions, affecting chromatin condensation and gene expression. Its distribution in plant cells is related to cell proliferation and differentiation stages. The methylation level of 5-Methyl-2'-deoxycytidine is low in proliferating cells and high in differentiated cells .

HY-A0248AS

Polymyxin B1-d7 TFA

Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

HY-B0464S1

Hydralazine-d5 hydrochloride

Hydralazine-d₅ (hydrochloride) is deuterium-labeled Hydralazine (hydrochloride) (HY-B0464). Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGE_E2; meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain .

HY-B0464S

Hydralazine-d4 hydrochloride

Hydralazine-d4 hydrochloride is the deuterium labeled Hydralazine hydrochloride. Hydralazine hydrochloride is an orally active, blood-brain barrier-permeable DNA methyltransferase inhibitor with vasodilatory, arterial smooth muscle relaxant and hypotensive activities. Hydralazine hydrochloride reactivates silenced tumor suppressor genes via mediating DNA demethylation, while exerting neuroprotective and anti-inflammatory properties. Hydralazine hydrochloride inhibits NOS-2 (iNOS) and COX-2, and reduces the production of NO and PGE_E2; meanwhile, Hydralazine hydrochloride scavenges reactive oxygen species and inhibits macrophage activation. Hydralazine hydrochloride alleviates motor dysfunction, neuropathic inflammatory pain, and formalin-induced somatic and emotional pain responses. In addition, Hydralazine hydrochloride directly induces DNA strand breaks and sister chromatid exchange, exhibiting certain mutagenic characteristics. Hydralazine hydrochloride has been widely used in studies on hypertension, various cancers (such as cervical cancer, leukemia), spinal cord injury and the mechanisms of inflammatory pain .

HY-W653970

5-Azacytidine-15N4
5-Azacytidine- ¹⁵N₄ is ¹³C and ¹⁵N labeled 5-Azacytidine. 5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation. 5-Azacytidine is incorporated into DNA to covalently trap *DNA methyltransferases* and contributes to reverse epigenetic changes. 5-Azacytidine induces cell autophagy .

HY-A0004S

Decitabine-13C5

Decitabine- ¹³C₅ (5-Aza-2'-deoxycytidine- ¹³C₅) is ¹³C labeled Decitabine. Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity .

HY-A0084AS

Procainamide-d4

Procainamide-d₄ (Procaine amide-d₄) is the deuterium labeled Procainamide (HY-A0084A). Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research .

HY-A0248AS1

Polymyxin B1-D-Leu-d7 TFA

Polymyxin B1-D-Leu-d₇ TFA is the deuterium labeled Polymyxin B1 (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment .

Targets Recommended: DNA Methyltransferase

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13642G

RG108	DNA Methyltransferase	Cancer
RG108 (GMP) is RG108 (HY-13642) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC₅₀=115 nM) that blocks the DNMTs active site. RG108 (N-Phthalyl-L-tryptophan) causes demethylation and reactivation of tumor suppressor genes, but it does not affect the methylation of centromeric satellite sequences .

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