Search Result

Results for "

Phosphorylases inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Kinase (2) Amino Acid Derivatives (1) Antibiotic (5) Apoptosis (5) Autophagy (1) Bacterial (5) Biochemical Assay Reagents (3) CaMK (1) DNA/RNA Synthesis (7) Drug Derivative (2) Drug Intermediate (2) Endogenous Metabolite (8) Fungal (2) Histone Methyltransferase (2) HIV (3) Influenza Virus (2) Isotope-Labeled Compounds (4) Methionine Adenosyltransferase (MAT) (2) Nucleoside Antimetabolite/Analog (16) Orthopoxvirus (2) Phosphatase (3) Phosphorylase (15) PKA (5) PKC (5) Reference Standards (11) Thymidylate Synthase (3) Trk Receptor (1) Urease (1)
By Research Areas:	Cancer (40) Cardiovascular Disease (9) Infection (14) Inflammation/Immunology (8) Metabolic Disease (20) Neurological Disease (2)
Oligonucleotides:	Nucleotide Analogs (1) Adenine Nucleotide (1)

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-15141

Staurosporine Maximum Cited Publications 207 Publications Verification Antibiotic AM-2282; STS; AM-2282	PKC PKA Apoptosis Bacterial Fungal Antibiotic	Infection Cancer
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-15424

5-Iodotubercidin 10+ Cited Publications NSC 113939; 5-ITu	Adenosine Kinase	Cancer
5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC₅₀ of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-16478

Trifluridine/tipiracil hydrochloride mixture 3 Publications Verification TAS-102; FTD/TPI	Nucleoside Antimetabolite/Analog Thymidylate Synthase	Cancer
Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a potent and orally active nucleoside antitumor agent. The composition of Trifluridine/tipiracil hydrochloride mixture (TAS-102) is a 1:0.5 mixture (on a molar basis) of alpha,alpha,alpha-tri-fluorothymidine (FTD) and thymidine phosphorylase inhibitor (TPI). Trifluridine/tipiracil hydrochloride mixture (TAS-102) shows the antitumor activity mainly via the inhibition of thymidylate synthase (TS) and incorporation into DNA .

HY-B0307

Idoxuridine 5+ Cited Publications 5-Iodo-2′-deoxyuridine; 5-IUdR; IdUrd	DNA/RNA Synthesis Phosphatase Orthopoxvirus	Infection Cancer
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits *phosphorylases. Idoxuridine can inhibit* viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.

HY-106406

Benzylacyclouridine 2 Publications Verification BAU; 5-Benzylacyclouridine	Drug Derivative	Cancer
Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine inhibits the metabolic activity of UPP1 and the activity of UPP2. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives .

HY-16210

Forodesine 15+ Cited Publications BCX-1777; Immucillin-H	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Forodesine (BCX-1777) is a highly potent and orally active *purine nucleoside phosphorylase* (PNP)** inhibitor with IC₅₀ values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels .

HY-N6732

K-252a 25+ Cited Publications SF2370; Antibiotic K 252a; Antibiotic SF 2370	Autophagy PKA PKC Trk Receptor CaMK	Infection Inflammation/Immunology
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-A0063

Tipiracil hydrochloride 5 Publications Verification	Nucleoside Antimetabolite/Analog	Cancer
Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

HY-156680

Vopimetostat TNG-462	Histone Methyltransferase	Cancer
TNG-462 is an orally active and selective PRMT5 inhibitor with anti-tumor activity against methylthioadenosine phosphorylase (MTAP) deficiency and/or methylthioadenosine (MTA) accumulation cancers .

HY-101496

MT-DADMe-ImmA 4 Publications Verification MTDIA; Methylthio-DADMe-Immucillin A	Histone Methyltransferase	Cancer
MT-DADMe-ImmA is an inhibitor of human 5'-methylthioadenosine phosphorylase (MTAP) with a K_i of 90 pM.

HY-13525

CP-91149 5+ Cited Publications	Biochemical Assay Reagents	Metabolic Disease Cancer
CP-91149 is a GP (glycogen phosphorylase) inhibitor. CP-91149 promotes glycogen resynthesis, but not its overaccumulation. CP-91149 has the potential for Type II (insulin-dependent) diabetes study .

HY-100126

Tubercidin 5+ Cited Publications 7-Deazaadenosine	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic	Infection
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-W008491

TK-112690	Phosphorylase	Inflammation/Immunology Cancer
TK-112690 is a UPP1 inhibitor. TK-112690 inhibits murine small intestinal uridine phosphorylase (UPase) with an IC₅₀ of 12.5 μM and human small intestinal UPase with an IC₅₀ of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study of cancer and pulmonary fibrosis .

HY-A0063A

Tipiracil 5 Publications Verification	Thymidylate Synthase Nucleoside Antimetabolite/Analog	Cancer
Tipiracil is a thymidine phosphorylase (TPase) inhibitor.

HY-16933

L-Alanosine 1 Publications Verification NSC-153353; SDX-102	Antibiotic DNA/RNA Synthesis	Infection Cancer
L-Alanosine (NSC-153353), an antibiotic from Streptomyces alanosinicus, has antineoplastic activity. L-Alanosine (NSC-153353) inhibits adenylosuccinate synthetase, which converts inosine monophospate (IMP) into adenylosuccinate. L-Alanosine is the inhibitor for methylthioadenosine phosphorylase (MTAP) .

HY-16209

Forodesine hydrochloride 15+ Cited Publications BCX-1777 hydrochloride; Immucillin-H hydrochloride	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active *purine nucleoside phosphorylase* (PNP)** inhibitor with IC₅₀ values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels .

HY-42680

D-Tagatose D-(-)-Tagatose	Endogenous Metabolite	Metabolic Disease Inflammation/Immunology Cancer
D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes .

HY-19396

Ingliforib 2 Publications Verification CP 368296; GPi 296	Phosphorylase	Cardiovascular Disease
Ingliforib (CP 368296) is a glycogen phosphorylase inhibitor, with IC₅₀s of 52, 352 and 150 nM for liver, muscle and brain glycogen phosphorylase, and has cardioprotective activity.

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

HY-19480

Ulodesine 1 Publications Verification BCX4208	Endogenous Metabolite	Metabolic Disease
Ulodesine is a *purine nucleoside phosphorylase* (PNP)** inhibitor. Ulodesine inhibits PNP with IC₅₀ value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-108615

CP-316819 GPi 819	Phosphorylase	Cardiovascular Disease Neurological Disease Metabolic Disease
CP-316819 (GPi 819) is a blood-brain barrier permeable glycogen phosphorylase inhibitor. CP-316819 inhibits hepatic glycogenolysis, safely reduces blood glucose in type 2 diabetes, and rarely induces hypoglycemia. CP-316819 increases brain glycogen reserves, protects neurons, alleviates hypoglycemic brain injury, and inhibits excessive platelet activation, exerting both neuroprotective and vasculoprotective effects. CP-316819 can be used in research related to hypoglycemia, thrombosis, autoimmune inflammatory diseases, and type 2 diabetes .

HY-I0210

4-Iodoaniline, 98%	Biochemical Assay Reagents Drug Intermediate	Cardiovascular Disease Cancer
4-Iodoaniline is a potent methemoglobin former. 4-Iodoaniline is also an intermediate. 4-Iodoaniline can be used to synthesize glycogen phosphorylase inhibitors. 4-Iodoaniline is used in the research of liver cancer and blood diseases .

HY-N1932

Bayogenin	Phosphorylase	Metabolic Disease
Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase .

HY-W010854

2'-Deoxyadenosine 5'-di-phos-phate disodium dADP disodium	DNA/RNA Synthesis	Others
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-102071

KIN59 5'-O-Tritylinosine; 5'-O-Trityl-inosine	Nucleoside Antimetabolite/Analog	Cancer
KIN59 (5’-O-Tritylinosine) is a potent thymidine phosphorylase allosteric inhibitor. KIN59 inhibits FGF2-stimulated cell growth. KIN59 inhibits the expression of p-FGFR1, P-Akt in FGF2 (10 ng/mL) stimulated cells. KIN59 shows anti-tumor activity .

HY-77537

7-Deazaxanthine 7DX	Thymidylate Synthase	Cardiovascular Disease
7-Deazaxanthine (7DX) is an inhibitor of thymidine phosphorylase (TPase). 7-Deazaxanthine inhibits TPase reaction in a concentration-dependent manner with an IC₅₀ value of 40 μM. 7-Deazaxanthine also has a significant angiogenesis inhibitory effect .

HY-106934A

Peldesine dihydrochloride 1 Publications Verification BCX 34 dihydrochloride	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active *purine nucleoside phosphorylase* (PNP)** inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .

HY-15141R

Staurosporine (Standard) Antibiotic AM-2282 (Standard); STS (Standard); AM-2282 (Standard)	Reference Standards PKC PKA Apoptosis Bacterial Fungal Antibiotic	Infection Cancer
Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-139037

8-Aminoguanine	Endogenous Metabolite	Metabolic Disease
8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-15424R

5-Iodotubercidin (Standard) NSC 113939 (Standard); 5-ITu (Standard)	Adenosine Kinase Reference Standards	Cancer
5-Iodotubercidin (Standard) is the analytical standard of 5-Iodotubercidin. This product is intended for research and analytical applications. 5-Iodotubercidin (NSC 113939), an ATP mimetic, is a potent adenosine kinase inhibitor with an IC50 of 26 nM. 5-Iodotubercidin (NSC 113939) initiates glycogen synthesis in isolated hepatocytes by causing inactivation of phosphorylase and activation of glycogen synthase. 5-Iodotubercidin (NSC 113939) also inhibits CK1, insulin receptor tyrosine kinase, phosphorylase kinase, PKA, CK2, PKC and Haspin .

HY-113585

1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride	Endogenous Metabolite	Others
1,4-Dideoxy-1,4-imino-D-arabinitol hydrochloride is a naturally occurring pyrrolidine alkaloid that acts as an inhibitor of glycogen phosphorylase and α-glucosidases, and is sourced from Arachniodes standishii and Angylocalyx boutiqueanus.

HY-I0210S

4-Iodoaniline-13C6	Isotope-Labeled Compounds Biochemical Assay Reagents Drug Intermediate	Cardiovascular Disease Cancer
4-Iodoaniline- ¹³C₆ is the ¹³C labeled 4-Iodoaniline (HY-I0210). 4-Iodoaniline is a potent methemoglobin former. 4-Iodoaniline is also an intermediate. 4-Iodoaniline can be used to synthesize glycogen phosphorylase inhibitors. 4-Iodoaniline is used in the research of liver cancer and blood diseases .

HY-106934

Peldesine BCX 34	Nucleoside Antimetabolite/Analog HIV	Infection Inflammation/Immunology Cancer
Peldesine (BCX 34) is a potent, competitive, reversible and orally active *purine nucleoside phosphorylase* (PNP)** inhibitor with IC₅₀s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine is also a T-cell proliferation inhibitor with an IC₅₀ of 800 nM. Peldesine has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .

HY-B0307R

Idoxuridine (Standard) 5-Iodo-2′-deoxyuridine (Standard); 5-IUdR (Standard); IdUrd (Standard)	Reference Standards Phosphatase Orthopoxvirus	Infection Cancer
Idoxuridine (Standard) is the analytical standard of Idoxuridine. This product is intended for research and analytical applications. Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) is an iodinated thymidine analogue that competitively inhibits phosphorylases. Idoxuridine can inhibit viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM . Idoxuridine shows anti-orthopoxvirus activity.

HY-128029

Glycogen phosphorylase-IN-1	Phosphorylase	Metabolic Disease
Glycogen phosphorylase-IN-1 (Compound 42) is an inhibitor for human liver glycogen phosphorylase (hlGPa) and hepatocyte glycogen-derived glucose production with IC₅₀s of 53 and 380 nM, respectively. Glycogen phosphorylase-IN-1 reveals efficacy towards type 2 diabetes .

HY-W750387

Immucillin-G	Nucleoside Antimetabolite/Analog	Metabolic Disease
Immucillin-G is a purine nucleoside phosphorylase (PNP) inhibitor. Immucillin-G can reduce urate levels and can be used for the research of metabolic disease, such as hyperuricemia .

HY-118047

CI 972 anhydrous	Nucleoside Antimetabolite/Analog	Inflammation/Immunology
CI 972 anhydrous is a potent, orally active, and competitive inhibitor of *purine nucleoside phosphorylase* (PNP) (K_i**=0.83 μM) under development as a T cell-selective immunosuppressive agent .

HY-W012670

2-Deoxy-L-ribose	Apoptosis	Cancer
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase .

HY-117172

CP320626	Phosphorylase	Metabolic Disease
CP320626 is a potent inhibitor of human liver glycogen phosphorylase (IC₅₀=205 nM). CP320626 reduces blood glucose in diabetic mice without changing plasma insulin levels. CP320626 can be used in the study of type 2 diabetes .

HY-108614

GPi688	Phosphorylase	Metabolic Disease
GPi688 is a potent and orally active *glycogen phosphorylase* (GPa)** inhibitor with IC₅₀s of 19 nM, 61 nM and 12 nM for human liver GPa, rat liver GPa and human skeletal muscle GPa, respectively . GPi688 can inhibit glucagons-mediated glucose output in rat primary hepatocytes. GPi688 can be used for researching glucagon-mediated hyperglycaemia .

HY-B0307A

Idoxuridine hydrate 5-Iodo-2′-deoxyuridine hydrate; 5-IUdR hydrate; IdUrd hydrate	DNA/RNA Synthesis Phosphatase	Infection Cancer
Idoxuridine (5-Iodo-2′-deoxyuridine, 5-IUdR, IdUrd) hydrate is an iodinated thymidine analogue that competitively inhibits *phosphorylases. Idoxuridine can inhibit* viral activity, particularly viral eye infections, including herpes simplex keratitis, by inhibiting DNA polymerase and affecting viral replication. Idoxuridine against feline herpesvirus has the IC₅₀ value of 4.3 μM .

HY-172805

Glycogen phosphorylase-IN-2	Phosphorylase	Metabolic Disease
Glycogen phosphorylase-IN-2 (compound 9C) is an inhibitor of glycogen phosphorylase with a K_i value of 1.9 nM and an IC₅₀ value of 4 nM .

HY-100320

AVE5688	Phosphorylase	Metabolic Disease
AVE5688 is an inhibitor of *glycogen phosphorylase* (GP), with IC₅₀s of 430 nM and 915 nM and K_d*s of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase* (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

HY-A0063R

Tipiracil hydrochloride (Standard)	Reference Standards Nucleoside Antimetabolite/Analog	Cancer
Tipiracil (hydrochloride) (Standard) is the analytical standard of Tipiracil (hydrochloride). This product is intended for research and analytical applications. Tipiracil (hydrochloride) is a thymidine phosphorylase inhibitor (TPI), used for cancer research.

HY-147969

Antiangiogenic agent 2	Nucleoside Antimetabolite/Analog	Cancer
Antiangiogenic agent 2 (compound 3b) is a potent thymidine phosphorylase inhibitor, with an IC₅₀ of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity .

HY-W552525

Deoxyadenosine diphosphate sodium	Phosphorylase	Infection
Deoxyadenosine diphosphate sodium is a nucleoside diphosphate, in which the nucleoside is deoxyadenosine. Deoxyadenosine diphosphate sodium participates in DNA synthesis and repair. Deoxyadenosine diphosphate sodium acts as the inhibitor of polynucleotide phosphorylase, interfers with the polymerization of ADP and CDP .

HY-171451

RMGPa-IN-1	Phosphorylase	Metabolic Disease
RMGPa-IN-1 (Compound 10C) is a rabbit muscle glycogen phosphorylase a (RMGPa) inhibitor with an IC₅₀ value of 82.5 μM. RMGPa-IN-1 is promising for research of diabetes .

HY-N1932R

Bayogenin (Standard)	Reference Standards Phosphorylase	Metabolic Disease
Bayogenin (Standard) is the analytical standard of Bayogenin (HY-N1932). This product is intended for research and analytical applications. Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase .

HY-106406R

Benzylacyclouridine (Standard) BAU (Standard); 5-Benzylacyclouridine (Standard)	Drug Derivative Reference Standards	Cancer
Benzylacyclouridine (Standard) is the analytical standard of Benzylacyclouridine. This product is intended for research and analytical applications. Benzylacyclouridine (BAU) is a potent and specific inhibitor of uridine phosphorylase, the first enzyme in the catabolism of uridine. Benzylacyclouridine can modulate the cytotoxic side effects of 5-fluorouracil (5-FU) and its derivatives .

Cat. No.	상품명

HY-L044

Nucleotide Compound Library

572 compounds

Nucleoside and nucleotide analogues are synthetic, chemically modified compounds that have been developed to mimic their physiological counterparts in order to exploit cellular metabolism and subsequently be incorporated into DNA and RNA to inhibit cellular division and viral replication. In addition to their incorporation into nucleic acids, nucleoside and nucleotide analogues can interact with and inhibit essential enzymes such as human and viral polymerases (that is, DNA-dependent DNA polymerases, RNA-dependent DNA polymerases or RNA-dependent RNA polymerases), kinases, ribonucleotide reductase, DNA methyltransferases, purine and pyrimidine nucleoside phosphorylase and thymidylate synthase. These actions of nucleoside and nucleotide analogues have potential therapeutic benefits — for example, in the inhibition of cancer cell growth, the inhibition of viral replication as well as other indications.

MCE offers a unique collection of 572 nucleotide compounds including nucleotide, nucleoside and their structural analogues. MCE Nucleotide Compound Library is a useful tool to discover anti-cancer and antiviral drugs for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	상품명	Type

HY-I0210

4-Iodoaniline, 98%	Biochemical Assay Reagents
4-Iodoaniline is a potent methemoglobin former. 4-Iodoaniline is also an intermediate. 4-Iodoaniline can be used to synthesize glycogen phosphorylase inhibitors. 4-Iodoaniline is used in the research of liver cancer and blood diseases .

HY-W010854

2'-Deoxyadenosine 5'-di-phos-phate disodium dADP disodium	Biochemical Assay Reagents
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

HY-W012670

2-Deoxy-L-ribose	Biochemical Assay Reagents
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase .

Cat. No.	상품명	Target	Research Area

HY-41121

Boc-L-Ala-OH 1 Publications Verification Boc-Ala-OH	Amino Acid Derivatives	Cancer
Boc-L-Ala-OH (Boc-Ala-OH) is a single N-protected amino acid ligand and a protected L-alanine derivative. Boc-L-Ala-OH promotes Pd (II)-catalyzed enantioselective C-H alkenylation and kinetic resolution. Boc-L-Ala-OH serves as a coupling reagent for the synthesis of liver-targeted glycogen phosphorylase inhibitors and P6A metabolites, and also acts as a negative control in synthesis studies of betulinic acid amino acid esters. Boc-L-Ala-OH is applicable to research on epidermoid squamous cell carcinoma .

HY-P1597

Malantide 1 Publications Verification	PKA PKC	Cancer
Malantide is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide is also an efficient substrate for PKC with a K_m of 16 μM .

HY-P1597A

Malantide TFA	PKA PKC	Cancer
Malantide TFA is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Malantide TFA is a highly specific substrate for PKA with a K_m of 15 μM and shows protein inhibitor (PKI) inhibition >90% substrate phosphorylation in various rat tissue extracts . Malantide TFA is also an efficient substrate for PKC with a K_m of 16 μM .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-15141

Staurosporine Maximum Cited Publications 207 Publications Verification Antibiotic AM-2282; STS; AM-2282	Infection Structural Classification Alkaloids Microorganisms Classification of Application Fields Marine natural products Marine microorganism Disease Research Fields Indole Alkaloids Source Classification	PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC₅₀s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC₅₀ of 3 μM. Staurosporine is an apoptosis inducer .

HY-N6732

K-252a 25+ Cited Publications SF2370; Antibiotic K 252a; Antibiotic SF 2370	Alkaloids Structural Classification Microorganisms Classification of Application Fields Inflammation/Immunology Disease Research Fields Indole Alkaloids Source Classification	Autophagy PKA PKC Trk Receptor CaMK
K-252a, a staurosporine analog, inhibits protein kinase, with IC₅₀ values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca ²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively . K-252a is a potent inhibitor (IC₅₀ of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene .

HY-100126

Tubercidin 5+ Cited Publications 7-Deazaadenosine	Infection Structural Classification Microorganisms Classification of Application Fields Antibiotics Antiviral Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC₅₀ of 0.02 μM . Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis . Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP . Tubercidin has antiviral activity .

HY-42680

D-Tagatose D-(-)-Tagatose	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Sweeteners Saccharides Monosaccharides Source Classification Food Research	Endogenous Metabolite
D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes .

HY-19480

Ulodesine 1 Publications Verification BCX4208	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Ulodesine is a *purine nucleoside phosphorylase* (PNP)** inhibitor. Ulodesine inhibits PNP with IC₅₀ value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .

HY-N1932

Bayogenin	Triterpenes Classification of Application Fields Terpenoids Cucurbitaceae Metabolic Disease Plants Bolbostemma paniculaum (Maxim)Franguet Disease Research Fields Source Classification	Phosphorylase
Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase .

HY-15141R

Staurosporine (Standard) Antibiotic AM-2282 (Standard); STS (Standard); AM-2282 (Standard)	Alkaloids Structural Classification Microorganisms Marine natural products Marine microorganism Indole Alkaloids Source Classification	Reference Standards PKC PKA Apoptosis Bacterial Fungal Antibiotic
Staurosporine (Standard) is the analytical standard of Staurosporine. This product is intended for research and analytical applications. Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer[1][2][3][4][5].

HY-N1932R

Bayogenin (Standard)	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Bolbostemma paniculaum (Maxim)Franguet Source Classification	Reference Standards Phosphorylase
Bayogenin (Standard) is the analytical standard of Bayogenin (HY-N1932). This product is intended for research and analytical applications. Bayogenin is a triterpenoid saponin and one of the main components of Medicago sativa saponins. Bayogenin is an inhibitor of glycogen phosphorylase .

HY-100126R

Tubercidin (Standard) 7-Deazaadenosine (Standard)	Structural Classification Microorganisms Antibiotics Antiviral Antibacterial Disease Research Other Antibiotics Source Classification	Reference Standards Bacterial DNA/RNA Synthesis Influenza Virus Antibiotic
Tubercidin (Standard) is the analytical standard of Tubercidin. This product is intended for research and analytical applications. Tubercidin (7-Deazaadenosine) is an antibiotic obtained from Streptomyces tubercidicus. Tubercidin inhibits the growth of Streptococcus faecalis (8043) with an IC50 of 0.02 μM[1]. Tubercidin inhibits polymerases by incorporating DNA or RNA, thereby inhibiting DNA replication, RNA and protein synthesis[2]. Tubercidin is a weak inhibitor of adenosine phosphorylase, and interferes with the phosphorylation of adenosine and AMP[1]. Tubercidin has antiviral activity[2].

HY-42680R

D-Tagatose (Standard) D-(-)-Tagatose (Standard)	Structural Classification Microorganisms Endogenous metabolite Saccharides Monosaccharides Source Classification	Reference Standards Endogenous Metabolite
D-Tagatose (Standard) is the analytical standard of D-Tagatose (HY-42680). This product is intended for research and analytical applications. D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.

Cat. No.	상품명	Chemical Structure

HY-I0210S

4-Iodoaniline-13C6
4-Iodoaniline- ¹³C₆ is the ¹³C labeled 4-Iodoaniline (HY-I0210). 4-Iodoaniline is a potent methemoglobin former. 4-Iodoaniline is also an intermediate. 4-Iodoaniline can be used to synthesize glycogen phosphorylase inhibitors. 4-Iodoaniline is used in the research of liver cancer and blood diseases .

HY-W771063

8-Aminoguanine-13C2,15N
8-Aminoguanine- ¹³C₂, ¹⁵N is the ¹³C- and ¹⁵N-labeled 8-Aminoguanine (HY-139037). 8-Aminoguanine is a endogenous purine. 8-Aminoguanine inhibits PNPase (purine nucleoside phosphorylase). 8-Aminoguanine induces diuresis/natriuresis/glucosuria .

HY-42680S1

D-Tagatose-13C-1

D-Tagatose- ¹³C-1 is the ¹³C labeled D-Tagatose (HY-42680). D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.

HY-42680S

D-Tagatose-13C

D-Tagatose- ¹³C is the ¹³C labeled D-Tagatose (HY-42680). D-Tagatose (D-(-)-Tagatose) is a natural low-calorie rare sugar. D-Tagatose inhibits the activities of sucrase, maltase and intestinal disaccharidases, reduces the digestion of sucrose and starch, and blocks the absorption of sucrose, maltose and glucose. D-Tagatose promotes glucokinase activity and inhibits glycogen phosphorylase activity via tagatose-1-phosphate, regulates the synthesis and decomposition of hepatic glycogen, reduces postprandial and fasting blood glucose levels, and improves hyperinsulinemia. D-Tagatose regulates lipid profiles, stimulates GLP-1 secretion, and exhibits prebiotic effects. D-Tagatose is a bulking sweetener. D-Tagatose can be used in research related to diabetes, hyperlipidemia, dental caries, atherosclerosis and type 2 diabetes.

Cat. No.	상품명		Classification

HY-W010854

2'-Deoxyadenosine 5'-di-phos-phate disodium dADP disodium		Nucleotide Analogs Adenine Nucleotide
2'-Deoxyadenosine 5'-di-phos-phate disodium (dADP disodium) is an inhibitor of bacterial poly(A) polymerase. It can be used to synthesize deoxyadenosine oligonucleotides with Escherichia coli polynucleotide phosphorylase and other enzymes .

온라인 문의

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
호칭			Country or Region *
고객명 *			회사명 *
Department *
메일주소 *			상품명 *
Cat. No.			Requested quantity *
전화번호 *
비고

온라인 문의

Inquiry Information

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

Phosphorylases inhibitor

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Oligonucleotides

Natural
Products