1. Cell Cycle/DNA Damage
  2. Nucleoside Antimetabolite/Analog
  3. CI 972 (anhydrous)

CI 972 (anhydrous) 

Cat. No.: HY-118047
Handling Instructions

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent.

For research use only. We do not sell to patients.

CI 972 (anhydrous) Chemical Structure

CI 972 (anhydrous) Chemical Structure

CAS No. : 115787-68-3

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Description

CI 972 anhydrous is a potent, orally active, and competitive inhibitor of purine nucleoside phosphorylase (PNP) (Ki=0.83 μM) under development as a T cell-selective immunosuppressive agent[1][2].

IC50 & Target

Ki: 0.83 μM (PNP)[1]

In Vivo

CI 972 anhydrous (5-150 mg/kg; p.o.) produces dose-dependent elevation of plasma inosine one hour after administration to rats[1].

Molecular Weight

297.76

Formula

C₁₁H₁₂ClN₅OS

CAS No.

115787-68-3

SMILES

O=C1C(NC(N)=C2CC3=CSC=C3)=C2NC(N)=N1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product name:
CI 972 (anhydrous)
Cat. No.:
HY-118047
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